Objective To discuss the efficacy of Baofukang combined with clindamycin injection in treatment of chronic cervicitis patients with high-risk human papilloma virus infection (hr-HPV).Methods Totally 100 patients who had chronic cervicitis with hr-HPV were selected and divided into two groups randomly.The patients in control group (49 cases) were given Baofukang.The patients in observation group (51 cases) were given Baofukang combined with clindamycin injection.The efficacy of Baofukang combined with clindamycin injection in treatment of chronic cervicitis patients with hr-HPV was evaluated by efficacy,HPV negative rate,inflammatory factors before and after treatment and adverse reaction during treatment.Results After treatment,the effective rate of observation group was 92.1％,and the effective rate of control group was 75.5％,the effective rate of observation group was higher than that of control group (P ＜ 0.05).After treatment,the HPV negative rate in observation group was 90.2％,the control group was 59.2％,the HPV negative rate of observation group was higher than that of control group (P ＜ 0.05).Before treatment,there was no statistical significance on hs-CRP,IL-6,and TNF-α between two groups.After treatment,the hs-CRP,IL-6,and TNF-α were decreased in two groups (P ＜ 0.05).The hs-CRP,IL-6,and TNF-α of observation group were lower than those of control group (P ＜ 0.05).There was no statistical significance on adverse reaction between two groups.Conclusion Baofukang combined with clindamycin injection had a good therapeutic effect on chronic cervicitis with hr-HPV.It could inhibit HPV and inflammatory factors well.It was safe and worthy of clinical use.

Objective To evaluate the effect of sufentanil combined with dexmedetomidine on analgesia in patients with pulmonary lobectomy.Method Totally 80 patients with pulmonary lobectomy in Yanan University Affiliated Hospital were collected from January 2014 to August 2016,which randomly divided into two groups:patients in control group (n-40) were given sufentanil 0.05 μg/(kg·h),and patients in observation group (n =40) were given sufentanil 0.03 μg/(kg·h) combined with dexmedetomidine 0.07 μg/(kg·h),The differences of hemodynamic change,VAS and Ramsay score,and adverse reaction at 1 h,6 h,12 h,24 h and 48 h after operation were compared.Results The hemodynamic change of all patients were relatively stable,and the more stable group B with lower MAP,HR and DBP at 12 h,and SBP at 6 h after operation further contributed the recovery of patients,which difference compared with group A was significance (P ＜ 0.05).However,the difference of SpO2 at the same time after operation was no significance.The VAS score blow 4 showed that the analgesia of all patients was satisfying.Comparing group B with group A,the VAS score was lower after 6 h at post-operation,which difference was significance (P ＜ 0.05).The Ramsay score of group B was higher than group A at 6h and 12 h,which difference was significance (P ＜ 0.05).The Ramsay score with range from 2 to 4 showed the sedation of all patients was not deficient or excessive.The incidence of nausea and vomit (2.5％) and dizziness (0％) in group B was lower than group A,with significant difference between two groups (P ＜ 0.05).Conclusion Combination dexmedetomidine with sufentanil to relief postoperative pain in patients undergoing pulmonary lobectomy is deserved popularization in clinic,which not only increases the efficiency analgesia and sedation,improves hemodynamic,but also decreases sufentanil-induced side-effect.

Objective To observe the preventive and therapeutic effect of Baimai Ointment on stoke,and explore the principle of promoting blood circulation and removing blood stasis.Method By dermal administration,the crude drug contents of Baimai Ointment given to rats were 0.075,0.150,and 0.300 g/kg respectively.Focal cerebral ischemic model was induced by the middle cerebral artery occlusion (MCAO),and the preventive and therapeutic effect of Baimai Ointment was evaluated.The degree of hematoma absorption in rats was measured to observe the effect on promoting blood circulation and removing blood stasis of Baimai Ointmnent.The acute blood stasis model and carotid thrombosis model were established in rats to study the effects on blood viscosity and thrombosis time.Results Baimai Ointment had no significant prevent effect on stroke in rats.It effectively improved behavior coordination in stroke model rats.It also significantly decreased the area of hematoma on rats,speeded up the repairment of local demage.After administration of Baimai Ointment,blood viscosity of blood stasis model rats was obviously decreased,while thrombosis time was effectively prolonged on carotid thrombosis model.Conclusion Baimai Ointment can significantly improve the behavior coordination in stroke model rats,plays a significant role in treatment,but no significant preventive effect,a preliminary study shows that the possible therapeutic principles may be promoting blood circulation and removing blood stasis.

Diabetes is a kind of worldwide chronic disease with high incidence,which threatens people's lives and work.With the development of DNA recombination technology,long-acting basal insulin analogues bring gospel and hope for patients with diabetes.Insulin glargine (IGla),detemir (IDet) and degludec (IDeg),as three basic types of insulin,commonly used in clinical practice that slowly absorbed and distributed by changing the structure,and relatively long acting time,more fit the physiological model of insulin secretion.Therefore,the existing studies of molecular structure,long-acting mechanism,safety evaluation and pharmacodynamic effects of three kinds of insulin preparations are briefly summarized.

Oleanolic acid has a widespread pharmacologic effect,including anti-inflammation,antitumor,anfidiabetes,anti-atherosclerosis,hepatoprotection,anti-osteoporosis,etc.Bioavailability of oleanolic acid by oral administration is low,and is absorbed by intestine through passive transport.Oleanolic acid dispersion preparation can increase its solubility and bioavailability,and concentrate on liver to help treat for hepatic disease.The pharmacokinetic parameters,process in body of oleanolic acid,and the pharmacokinetic feature of oleanolic acid dispersion and its prodrug are reviewed,and its research advance on pharmacokinetics is summarized,which provides a reference for rational utilization of oleanolic acid.

Tumor is a seriously disease that endanger human health.Gastrointestinal cancer is one of the most prevalent types of digestive system cancers among the Chinese population.While radiotherapy and chemotherapy kill cancer cells,their toxicity to normal cells cannot be ignored.Hence,polysaccharides from Chinese materia medica (CMM) have been the focus of anti-tumor research,as they can improve functions of the immune system and do not harm to normal cells.In this review,we have analyzed the recent advances in the study of the effects of polysaccharides from CMM on human gastric cancer cell lines (MGC-803 and SGC-7901) and intestinal tumor cell lines (LoVo,HCT-116,and HT-29) in vitro.The purpose of this study is to provide a material basis for clinical research of polysaccharides from CMM.

Objective To examine whether androgen deprivation therapy (ADT) is associated with increased risk of diabetes in men with prostate cancer (Pca).Methods The study data were systematically searched from Medline,Embase,and Cochrane Library Central Register.Studies comparing ADT vs control aimed at treating Pca,reporting diabetes as outcome were included.Results Eight studies met inclusion criteria with a total of 65 695 ADT users and 91 893 non-ADT users investigating the relationship between ADT and diabetes.The incidence of diabetes was 39％ higher in ADT groups,and significant association was observed in overall analysis [RR =1.39,95％CI(1.27-1.53),P ＜ 0.01].In subgroup-analyses stratified by ADT types,diabetes was found to be significantly associated with gonadotropin-releasing hormone (GnRH) alone [RR =1.45,95％CI(1.36-1.54),P ＜ 0.01),GnRH plus oral anti-androgen (AA) [RR =1.40,95％CI(1.01-1.93),P ＜ 0.01] and Orchiectomy [RR =1.34,95％CI(1.20-1.50),P ＜ 0.01],but not with AA alone [RR =1.33,95％CI(0.75-2.36),P =0.33].Conclusions ADT,especially GnRH alone,GnRH plus AA and orchiectomy can increase the incidence of diabetes in patients with Pca.

Objective To study the therapeutic effects of Alprostadil Injection and Composite Salvia Injection on diabetic foot.Methods Selected 210 cases of patients with diabetic foot who were treated in our hospital from January 2012 to December 2016,divided into three groups randomly.The group A was treated with Alprostadil Injection,group B was treated with Composite Salvia Injection,the group C was treated with Alprostadil Injection and Composite Salvia Injection.The clinical therapeutic effects of the three groups were compared,and the levels of blood lipid,urea nitrogen,creatinine,beta-globulin and urinary microalbumin before and after treatment were compared.Results After treatment,the effective rate of the group C was 92.86％ (65/70),significantly higher than that of the group A and B (P ＜ 0.05).After treatment,the levels of TG,TC and LDL-C in the three groups were significantly lower than before treatment (P ＜ 0.05),HDL-C levels were significantly higher than before treatment (P ＜ 0.05),and the group C was more significant (P ＜ 0.05).After treatment,the levels of urea nitrogen,creatinine,beta 2 and urinary microalbumin were significantly decreased in the three groups than before (P ＜ 0.05),and the group C was more significant (P ＜ 0.05).Conclusion The effect of Alprostadil Injection and Composite Salvia Injection on diabetic foot is better,which is safe and effective.

Objective To investigate the effect of citalopram hydrobromide tablets on cognitive function and inflammatory factors in patients with recurrent bipolar disorder (BPD),and to analyze its possible mechanism of action.Methods 104 patients with recurrent BPD in our hospital from July 2014 to December 2015 were selected,and they were divided into observation group and control group by random number table,52 cases in each group.Control group was given sodium valproate,while observation group was given citalopram hydrobromide tablets and sodium valproate.After 8-week treatment,the emotional state,cognitive function,inflammatory factors were compared between the two groups.Results Before treatment,HAMD score,BPMS score of two groups were not statistically significant.After 8 weeks of treatment,HAMD score and BPMS score of two groups were significantly lower than those in the same group before treatment (P ＜ 0.01);and the observation group HAMD score and BPMS score were significantly lower than the control group (P ＜ 0.01).Before treatment,TMT-A,TMT-B time of two groups were not statistically significant.After 8 weeks of treatment,TMT-A and TMT-B time of two groups were significantly shorter than the same group before treatment (P ＜ 0.05).TMT-A TMT-B in the observation group were significantly shorter than the control group (P ＜ 0.05).The content of serum MIF,IL-1 beta and IL-6 in two groups before treatment were not statistically significant.After 8 weeks of treatment,the contents ofMIF,IL-1 beta,IL-6 in two groups were significantly lower than the same group before treatment (P ＜ 0.05).And the levels of serum MIF,IL-1 beta,IL-6 in observation group were significantly lower than the control group (P ＜ 0.05).Conclusion Citalopram hydrobromide tablets can relieve clinical symptoms,improve cognitive function,and it possibly has relations with inhibiting the expression of inflammatory factors.

Objective To investigate Huaiqihuang particles in treatment of children with bron chialasthma and effect on immune function.Methods 100 cases of children with bronchial asthma were randomly divided into control group and treatment group,50cases in each group,all were given routine western medicine treatment,and the treatment group combined with Huaiqihuang particles.The levels of interleukin-4 (IL-4),IL-5 and interferon gamma (IFN-γ),diurnal and nocturnal symptom scores before and after treatment and clinical efficacy and recurrence rate in followed up for 3 months in two groups were compared.Results After treatment,serum IL-4,IL-5 levels of the two groups were significantly decreased,IFN-γ levels were significantly increased in the same group before and after treatment,the difference was statistically significant (P ＜ 0.05).,serum IL-4 and IL-5 levels of treatment group were significantly lower than the control group,IFN-γ levels were significantly higher than the control group,there was statistically significant difference between groups (P ＜ 0.05).After treatment,daytime and nighttime symptom scores of two groups were significantly reduced than before treatment (P ＜ 0.05).And the treatment group was significantly lower than the control group (P ＜ 0.05).The total effective rate of the treatment group (96％) was significantly better than that of the control group (82％) (P ＜ 0.05).The treatment group recurred in 3 cases (6％),and the control group relapsed in 12 cases (24％).The recurrence rate of the treatment group was lower than that of the control group (P ＜ 0.05).Conclusion Huaiqihuang particles can effectively improve the immune function of patients with bron chialasthrna,enhance efficacy and reduce recurrence.