Rheumatoid arthritis(RA)is a chronic inflammatory autoimmune disease that can affect joints and extra-articular organs,including the heart,kidneys,lungs,digestive system,eyes,skin,and nervous system.During RA,mitochondrial ho-meostasis is altered,leading to the production of inflammatory mediators and joint damage by af-fecting cartilage and synovial tissues.Regulating mi-tochondrial homeostasis is a key step in slowing the progression of RA.This study conducts a com-prehensive literature review on the topics of"rheu-matoid arthritis"and"mitochondrial homeostasis"over the past decade.It aims to summarize and an-alyze the factors contributing to mitochondrial ho-meostasis imbalance in RA,as well as the potential role of modulating mitochondrial homeostasis in ameliorating RA,with the ultimate goal of offering novel insights and approaches for RA treatment.

Rheumatoid arthritis(RA)is a chronic inflammatory autoimmune disease that can affect joints and extra-articular organs,including the heart,kidneys,lungs,digestive system,eyes,skin,and nervous system.During RA,mitochondrial ho-meostasis is altered,leading to the production of inflammatory mediators and joint damage by af-fecting cartilage and synovial tissues.Regulating mi-tochondrial homeostasis is a key step in slowing the progression of RA.This study conducts a com-prehensive literature review on the topics of"rheu-matoid arthritis"and"mitochondrial homeostasis"over the past decade.It aims to summarize and an-alyze the factors contributing to mitochondrial ho-meostasis imbalance in RA,as well as the potential role of modulating mitochondrial homeostasis in ameliorating RA,with the ultimate goal of offering novel insights and approaches for RA treatment.