Objective:To investigate the correlation between arcuate fasciculus(AF),superior longitudinal fasciculus(SLF),inferior longitudinal fasciculus(ILF),and post-stroke aphasia(PSA)by diffusion tensor imaging(DTI).Method:Fourteen patients with post-stroke aphasia were included,while 18 healthy individuals with gender and age matching were recruited as controls.Western aphasia battery(WAB)and DTI were performed in two groups of participants.Result:Compared with normal healthy controls,aphasic patients had dominant side AF,SLF-Ⅱ,SLF-Ⅲ,and ILF damage,with a significant decrease in fiber FA value,fiber quantity,and fiber length(P<0.05).However,dominant side SLF-I,non dominant side AF,SLF-I,SLF-Ⅱ,and SLF-Ⅲ had no significant damage(P>0.05).The non-dominant side ILF fiber quantity of non-dominant side in the aphasic group was significantly lower than that in the healthy control group(P<0.05).However,there were no significant decrease in the FA value and fiber length between two groups(P>0.05).There was no significant correlation between specific single bundle fi-ber damage and WAB's AQ,spontaneous speech,auditory comprehension,repetition and naming scores(P>0.05).Conclusion:The injury of AF,SLF-Ⅱ,SLF-Ⅲ,and ILF in the dominant side of the brain is an important central mechanism for the occurrence of PSA.

Objective:To investigate the correlation between arcuate fasciculus(AF),superior longitudinal fasciculus(SLF),inferior longitudinal fasciculus(ILF),and post-stroke aphasia(PSA)by diffusion tensor imaging(DTI).Method:Fourteen patients with post-stroke aphasia were included,while 18 healthy individuals with gender and age matching were recruited as controls.Western aphasia battery(WAB)and DTI were performed in two groups of participants.Result:Compared with normal healthy controls,aphasic patients had dominant side AF,SLF-Ⅱ,SLF-Ⅲ,and ILF damage,with a significant decrease in fiber FA value,fiber quantity,and fiber length(P<0.05).However,dominant side SLF-I,non dominant side AF,SLF-I,SLF-Ⅱ,and SLF-Ⅲ had no significant damage(P>0.05).The non-dominant side ILF fiber quantity of non-dominant side in the aphasic group was significantly lower than that in the healthy control group(P<0.05).However,there were no significant decrease in the FA value and fiber length between two groups(P>0.05).There was no significant correlation between specific single bundle fi-ber damage and WAB's AQ,spontaneous speech,auditory comprehension,repetition and naming scores(P>0.05).Conclusion:The injury of AF,SLF-Ⅱ,SLF-Ⅲ,and ILF in the dominant side of the brain is an important central mechanism for the occurrence of PSA.

Life science and medical research involving human beings cannot be separated from the support of research participants.The safety,health,and rights and interests of research participants are the primary considerations in clinical research,and their rights and interests include the right of compensation,privacy protection,health and so on.Protecting the compensation rights of research participants is a necessary responsibility of the research-related departments and personnel.Based on laws and regulations and literature review,and combined with practical experience,this paper made an in-depth discussion on compensation rights.It puts forward the types of compensation(conventional compensation,research-related damage compensation),compensation principles(necessity,timeliness,appropriateness,fairness),compensation elements(method,amount,plan,consent,notification,and reference of compensation),compensation under special circumstances(compensation for participants without or with limited informed consent ability and withdraw from the study midway),protection measures of compensation right(sponsor/contract research organizations,research institutions,research management departments,(main)researchers and research teams,ethics(review)committee).The compensation rights should be implemented to protect research participants.