Based on the technical applications of Internet of Things(IoT)technology in data collection and transmission,this study proposes an intelligent management model in areas including equipment sharing and allocation,equipment utilization ef-ficiency analysis,equipment maintenance management,and preventive maintenance.The research optimizes management path-ways and operational models to enhance management efficiency and quality.This work aims to provide valuable references and in-sights for researchers in the field of medical equipment refined management innovation design,offering practical solutions for ad-vancing intelligent transformation in medical equipment management.

Objective The study intends to develop a multi－dimensional specific scale for the primary family caregivers of cancer patients,verify its reliability and validity,and reveal the burden level of the primary family caregivers of cancer patients.Methods This study investigated the primary family caregivers of cancer patients by questionnaire survey in Harbin of two medical institutions,finally we recalled 571 valid questionnaires.The study used SPSS 27.0 and AMOS 28.0 software to conduct reliability and validity analysis.The critical value of the burden score was determined by the quartile method to evaluate the burden level.Results The revised scale includes 21 items in 5 dimensions.The Cronbach's α coefficient range of the total scale and each dimension of the scale was 0.798~0.922,the Omega coefficient range was 0.806~0.918,and the split－half reliability range was 0.753~0.862.The average variance extracted(AVE)value and composite reliability(CR)value of the five dimensions of the scale meet the criteria,and the correlation coefficient between each dimension is less than the square root of AVE.Based on the critical value,there are 54.8%of carers suffer from moderate or heavy burdens.Among them,the financial burden and the care burden have the highest scores.Conclusion It shows that the burden scale for primary family caregivers of cancer patients has good reliability and validity.There are more than half of carers suffer from relatively heavy burden.Policymakers should draw up policies to support economic medical expense reimbursement and last comfort service.

Based on the technical applications of Internet of Things(IoT)technology in data collection and transmission,this study proposes an intelligent management model in areas including equipment sharing and allocation,equipment utilization ef-ficiency analysis,equipment maintenance management,and preventive maintenance.The research optimizes management path-ways and operational models to enhance management efficiency and quality.This work aims to provide valuable references and in-sights for researchers in the field of medical equipment refined management innovation design,offering practical solutions for ad-vancing intelligent transformation in medical equipment management.

Objective The study intends to develop a multi－dimensional specific scale for the primary family caregivers of cancer patients,verify its reliability and validity,and reveal the burden level of the primary family caregivers of cancer patients.Methods This study investigated the primary family caregivers of cancer patients by questionnaire survey in Harbin of two medical institutions,finally we recalled 571 valid questionnaires.The study used SPSS 27.0 and AMOS 28.0 software to conduct reliability and validity analysis.The critical value of the burden score was determined by the quartile method to evaluate the burden level.Results The revised scale includes 21 items in 5 dimensions.The Cronbach's α coefficient range of the total scale and each dimension of the scale was 0.798~0.922,the Omega coefficient range was 0.806~0.918,and the split－half reliability range was 0.753~0.862.The average variance extracted(AVE)value and composite reliability(CR)value of the five dimensions of the scale meet the criteria,and the correlation coefficient between each dimension is less than the square root of AVE.Based on the critical value,there are 54.8%of carers suffer from moderate or heavy burdens.Among them,the financial burden and the care burden have the highest scores.Conclusion It shows that the burden scale for primary family caregivers of cancer patients has good reliability and validity.There are more than half of carers suffer from relatively heavy burden.Policymakers should draw up policies to support economic medical expense reimbursement and last comfort service.

Scientifically preparing technical requirement for medical equipment can ensure that the purchase results meet the actual needs of the hospital.This study introduces the platform guarantee model implemented by the First Affiliated Hospital of Sun Yat-sen University in the management of medical equipment,analyzes the advantages,disadvantages,opportunities,and challenges of technical requirement preparation based on this model management,and proposes optimization strategies based on the analysis results,aiming to provide reference for the technical requirement preparation in general hospitals.

Scientifically preparing technical requirement for medical equipment can ensure that the purchase results meet the actual needs of the hospital.This study introduces the platform guarantee model implemented by the First Affiliated Hospital of Sun Yat-sen University in the management of medical equipment,analyzes the advantages,disadvantages,opportunities,and challenges of technical requirement preparation based on this model management,and proposes optimization strategies based on the analysis results,aiming to provide reference for the technical requirement preparation in general hospitals.

Transforming growth factor beta1 (TGF-β1) is the product and adjusting factor of the hepatocyte immune process when Hepatitis B virus (HBV) invades. There was a correlation among the level of TGF-β1, immune cell cytokines and HBV replication during antiviral therapy. It has an important clinical significance for the researchers to investigate dynamic change of TGF-β1 in chronicviral hepatitis type B (CHB) immunological response and antiviral treatment.

Objective To identify the role of miR-124 in regulating the radiosensitivity and the epithelial-mesenchymal transition (EMT) of nasopharyngeal carcinoma (NPC). Methods Transient transfection of cells with miR-124 mimic or inhibitor was performed and wound-healing assay was used to investigate the role of miR-124 in the EMT of NPC. The apoptosis affected by miR-124 was also measured after irradiation , followed by investigating the cell proliferation by EdU assay. Finally , proteins of Akt and ERK associated with EMT and radiosensitivity, were measured by western blot. Results The migration index from NPC cell line indicated that miR-124 repressed the EMT. The results from caspase-3 activity assay showed that caspase-3 activity after irradiation significantly increased in miR-124 mimic group compared with the control group (P < 0.01). It was also confirmed that irradiation led to a higher percentage of apoptosis in miR-124 group compared with the control group in NPC cells. Cell proliferation after irradiation was significantly decreased in MiR-124 group as compared with control group . MiR-124 inhibited the protein expression of p-Akt . Conclusion MiR-124 may repress the EMT and decrease radio-resistance of NPC via p-Akt signaling pathway , which may provide a new insight into radio-resistance in NPC.

Objective The radiotherapy resistance is one of important causes for nasopharyngeal carcinoma(NPC) treatment failure.Junctional adhesion molecule A(JAMA)is closely correlated with the tumor poor prognosis.Thus this experiment is to in vestigate the relationship between JAMA expression and the radiosensitivity of NPC.Methods To overexpress or interfere the JAMA expression in CNE2 and HONE1 cell lines.Then different doses of X-ray were adopted to conduct irradiation.The cell clone formation capacity and cellular apoptosis change were detected after 24 h.The role of JAMA in the NPC radiotherapy was understand.The related signal pathway protein in cell lines with different JAMA expression was detected by Western blot.Results The cell lines with low JAMA expression were more sensitive to radiotherapy:After low JAMA expression,the D0 value in the CNE2 cell line was decreased from 3.26 ±0.78 to 1.92 ± 0.23;the Dq value was decreased from 46.51 ± 4.27 to 32.12 ± 3.19.The radio therapy induced apoptosis was significantly increased in the cell lines with low JAMA expression,after low JAMA expressing,thcellular apoptosis was elevated from 6.9 ％ ± 0.9 ％ to 13.7 ％ ± 1.3 ％;the HONE1 cellular apoptosis was elevated from 6.5 ％ + 1.1 ％ to 12.3 ％ ± 1.7％;JAMA overexpression cell lines were significantly decreased.The preliminary mechanism research results showed that JAMA played the effect via Akt signal pathway.Conclusion This research results verifiy that JAMA expression level is closely correlated with the radiosensitivity of NPC cell line:JAMA can increase the radiotherapy resistance of NPC cell lines,which provides a new feasible research direction for NPC enhancing radiosensitivity.

A new clinical teaching mode of standardized treatment in colorectal cancer for fellows in training is reported here with good results. This one-year program included medical ethics education, humanistic management, pre job training, clinical thinking mode, surgery teaching, and computerized teaching. This new clinical teaching mode with distinct features is effective and introduced in this article.
Colorectal Neoplasms ; Education, Medical, Graduate ; Humans