Tic disorders in children refer to the neurodevelopmental disorders usually occurring in childhood and adolescence.Guided by the theory of five-zang-organ correlation,Professor Li Yirui approaches the treatment of tic disorders in children and comorbidities primarily from the perspective of liver-spleen disharmony,and points out that the pathogenesis is due to liver-spleen disharmony,wind-phlegm disturbance,and mutual involvement of the five zang organs.In clinical practice,Professor Li established the therapeutic principle of regulating the liver and spleen,extinguishing wind,and resolving phlegm,and adopted the four liver-regulating methods(calming liver,soothing liver,clearing liver,and softening liver)to extinguish wind and stop tics,as well as the four spleen-regulating methods(replenishing spleen,activating spleen,awakening spleen,and dredging spleen)to strengthen body resistance and support healthy qi.The self-formulated Fupi Xifeng Decoction(composed of Pseudostellariae Radix,Atractylodis Macrocephalae Rhizoma,Poria,Glycyrrhizae Radix et Rhizoma,Bupleuri Radix,Paeoniae Radix Alba,Uncariae Ramulus cum Uncis,Gastrodiae Rhizoma,Pinelliae Rhizoma Praeparatum,Citri Reticulatae Pericarpium,Os Draconis,etc.)serves as the basic formula,herbs directing to the affected regions were flexibly used,and insect drugs were occasionally adopted for refractory cases.The treatment for tic disorders in children focus on simultaneous regulation of the five zang-organs by modified use of herbs for dispersing wind and benefiting lung,tranquilizing heart and calming spirit,and supplementing liver and kidney to address comorbidities and secondary symptoms.Additionally,integrated internal-external treatment,relieving the discomforts physically and mentally,and family-centered comprehensive care are also taken into account to achieve optimal outcomes.

Objective:To summarize the evidence of diet management in patients with chronic kidney disease (CKD) in stage 3-5 D, so as to provide a reference for clinical nursing.Methods:After establishing evidence-based nursing questions, according to the "6S evidence model", the evidence on diet management of patients with CKD in stage 3-5 D was searched by computer, including computer decision support system evidence, guidelines, best evidence summary and systematic review. The search time limit was from the establishment of the database to September 2020. The guideline quality assessment was independently completed by two research nurses and a doctor of nephrology. The quality assessment of non-guideline article was independently completed by two research nurses, and an evidence-based instructor participated in decision-making. The evidence was extracted, evaluated and graded using the Joanna Briggs Institute (JBI) 2014 version of the intervention research evidence pre-grading system.Results:A total of 19 articles that met the requirements were included, including 5 guidelines, 8 systematic reviews, 4 randomized controlled trials, 1 clinical decision, and 1 national standard. A total of 22 pieces of the best evidence on diet management of patients with CKD in stage 3-5 D were summarized from three aspects, namely, diet/nutrition assessment, diet management, teamwork and education.Conclusions:The best evidence of diet management in patients with CKD in stage 3-5 D provides a certain reference for clinical practice, so as to improve the quality of diet management in patients with CKD and the clinical outcomes of patients.

【Objective】To observe the effect of liguistrazine(Liz)on cerebral and serum monoamine neurotransmitter contents in spontaneous hypertension rats (SHR).【Methods】Twenty-four SHR rats were randomized into model group,hightdose Liz group(40 mg?kg-1?d-1),low-dose Liz group(20 mg?kg-1?d-1),and votalin group(4 mg?kg-1?d-1).The rats received gastric gavage of corresponding drugs according to the experimental design for 14 days.After treatment,the serum and hippocampal contents of dopamine,5-hydroxytryptamine and norepinephrine(NE)were detected with high performance liquid chromatography(HPLC).【Results】 High-and low-dose Liz markedly decreased cerebral NE content,increased serum and cerebral DA and 5-HT contents(P

Objective To observe the therapeutic effect of spleen-invigorating and superficies-consolidating therapy combined with life style intervention for improving constitution of recurrent respiratory tract infection(RRTI) children.Methods One hundred and twenty RRTI children were classified into excessive yang with deficiency yin syndrome(N = 60) and excessive yin with deficiency yang syndrome(N = 60).Then the excessive yang with deficiency yin syndrome were equally randomized into herbal medicine group Ⅰ and western medicine group Ⅰ,and excessive yin with deficiency yang syndrome were equally randomized into herbal medicine group Ⅱ and western medicine group Ⅱ.Herbal medicine groups Ⅰ and Ⅱ were given Fuganning Oral Liquid and life style intervention,and western medicine groups Ⅰand Ⅱ were given thymic peptide capsules and life style intervention.Eight weeks constituted one treatment course.The score of symptoms before and after treatment,and the therapeutic effect were compared after 2 treatment courses.Results(1) The symptoms score was improved obviously in herbal medicine groups and western medicine groups(P 0.05).The difference of therapeutic effect was significant between both of herbal medicine groups(P