Objective:To construct prediction model based on particle swarm optimization long short-term memory(PSO-LSTM)algorithm for medical consumables,so as to predict the consumption of medical consumables and realize the fine management for medical consumables.Methods:The consumption of medical consumables was analyzed through constructed the PSO-LSTM prediction model,and then,the consumption of medical consumables was assessed.A total of 900 medical consumables which were clinically used in the Center of Endoscopy of Nanjing Tianyinshan Hospital Affiliated to China Pharmaceutical University from March to August 2024 were selected,and they were randomly divided into conventional management mode group(n=450 consumables)and PSO-LSTM management mode group(n=450 consumables)by random number table method,so as to conduct management for consumables.The management time,management timeliness,situation of monthly management of medical consumables,and predicted accuracy of consumption amount of medical consumables of two management mode in single diagnosis and treatment were compared.Results:The prepared time,delivered time,response time of temporary application,and the time of returning storehouse of medical consumables in PSO-LSTM model management mode were respectively(3.36±1.66),(9.54±2.69),(3.69±1.65)and(3.47±1.87)min,which were all less than those in conventional management mode,and the differences were statistically significant(t=7.76,13.811,28.147,39.105,P<0.05).The timeliness of supplementing medical consumables,shortage warning and proposing treatment methods of using PSO-LSTM model management mode were respectively(0.87±0.23),(3.26±0.87)and(14.98±2.65)min,which were all less than those of using conventional management mode,and the differences of them were statistically significant(t=4.228,15.482,13.420,P<0.05).In 450 medical consumables of the center of endoscopy,the amounts of the monthly average emergency purchasing and monthly average shortage were respectively 20 and 22 in using PSO-LSTM model management mode,accounting for 4.44%and 4.89%,all of which were lower than those of conventional management mode,and the differences of them were statistically significant(x2=10.364,11.835,P<0.05).The prediction results of using PSO-LSTM model management mode for disposable infusion device and disposable auxiliary kit of gastroscopy were closer to the actual consumption than the conventional management mode,while the differences of them were not significant(P>0.05).Conclusion:The application of the management mode of predictive model of medical consumables based on PSO-LSTM algorithm in the management of medical consumables of the center of endoscopy in hospital can accurately assess the consumption of medical consumables,and provide scientific basis for the procurement decision of medical consumables,and achieve fine management for various kinds of medical consumables,and reduce the cost of medical consumables in the center of endoscopy.

Objective:To assess the efficacy and safety of Tacrolimus（TAC）in combination with glucocorticosteroid（GC）for treating IgA vasculitis nephritis（IgAVN）in children.Methods:A retrospective analysis was conducted on pediatric patients who were diagnosed with IgAVN from January 2015 to January 2022 in Children's Hospital of Hebei Province.The patients presented with nephrotic-range proteinuria or persistent urine protein（>0.5g/24 h）despite adequate glucocorticoid and other treatments in patients who do not reach massive proteinuria levels.They were treated with TAC combined with GC. The following laboratory parameters were obtained for outcome assessment: 24-hour urinary protein excretion, serum albumin, serum creatinine levels, and fasting blood glucose measurements. The efficacy and adverse reactions of TAC were summarized.Results:A total of 97 children (55 males and 42 females) were included. The average age of diagnosis of IgA vasculitis was (8.65±2.46) years, and 95.9% of the children developed renal involvement within 30 days after diagnosis. Pathological examination of renal puncture: 5 cases of grade Ⅱa, 2 cases of grade Ⅱb, 31 cases of grade Ⅲa, 57 cases of grade Ⅲb, and 2 cases of grade Ⅳb.Remission rate at 3 months was 96.9%（94/97）.Three patients failed to achieve clinical remission who were treaed with other immunosuppressants.After 1, 3, 6 and 12 months of TAC treatment, the urine protein levels of 94 children were lower than those before treatment, and the differences were statistically significant ( P < 0.05), showing a gradual downward trend. Serum albumin levels were higher than those before treatment, and the differences were statistically significant ( P < 0.05), showing a gradual upward trend.After 3 months and 6 months of TAC treatment, the serum creatinine and fasting blood glucose of the children increased. With the remission of the disease, TAC dosage decreased, the mean values of serum creatinine and fasting blood glucose decreased after 12 months of treatment.The average treatment time of TAC was (10.8±2.6) months, the average follow-up time was (3.33±1.56) years, and the longest follow-up time was 8 years. During the follow-up period, there were no serious adverse reactions such as gastrointestinal discomfort, liver function damage and severe infection. After stopping GC and TAC treatment, 80 children got sustained remission. Conclusion:The combination of TAC and GC has been proved to be effective in treating IgAVN in children.The overall effective rate is high,and clinical remission can be achieved quickly with relatively mild adverse reactions.

Objective:To assess the efficacy and safety of Tacrolimus（TAC）in combination with glucocorticosteroid（GC）for treating IgA vasculitis nephritis（IgAVN）in children.Methods:A retrospective analysis was conducted on pediatric patients who were diagnosed with IgAVN from January 2015 to January 2022 in Children's Hospital of Hebei Province.The patients presented with nephrotic-range proteinuria or persistent urine protein（>0.5g/24 h）despite adequate glucocorticoid and other treatments in patients who do not reach massive proteinuria levels.They were treated with TAC combined with GC. The following laboratory parameters were obtained for outcome assessment: 24-hour urinary protein excretion, serum albumin, serum creatinine levels, and fasting blood glucose measurements. The efficacy and adverse reactions of TAC were summarized.Results:A total of 97 children (55 males and 42 females) were included. The average age of diagnosis of IgA vasculitis was (8.65±2.46) years, and 95.9% of the children developed renal involvement within 30 days after diagnosis. Pathological examination of renal puncture: 5 cases of grade Ⅱa, 2 cases of grade Ⅱb, 31 cases of grade Ⅲa, 57 cases of grade Ⅲb, and 2 cases of grade Ⅳb.Remission rate at 3 months was 96.9%（94/97）.Three patients failed to achieve clinical remission who were treaed with other immunosuppressants.After 1, 3, 6 and 12 months of TAC treatment, the urine protein levels of 94 children were lower than those before treatment, and the differences were statistically significant ( P < 0.05), showing a gradual downward trend. Serum albumin levels were higher than those before treatment, and the differences were statistically significant ( P < 0.05), showing a gradual upward trend.After 3 months and 6 months of TAC treatment, the serum creatinine and fasting blood glucose of the children increased. With the remission of the disease, TAC dosage decreased, the mean values of serum creatinine and fasting blood glucose decreased after 12 months of treatment.The average treatment time of TAC was (10.8±2.6) months, the average follow-up time was (3.33±1.56) years, and the longest follow-up time was 8 years. During the follow-up period, there were no serious adverse reactions such as gastrointestinal discomfort, liver function damage and severe infection. After stopping GC and TAC treatment, 80 children got sustained remission. Conclusion:The combination of TAC and GC has been proved to be effective in treating IgAVN in children.The overall effective rate is high,and clinical remission can be achieved quickly with relatively mild adverse reactions.

Objective:To construct prediction model based on particle swarm optimization long short-term memory(PSO-LSTM)algorithm for medical consumables,so as to predict the consumption of medical consumables and realize the fine management for medical consumables.Methods:The consumption of medical consumables was analyzed through constructed the PSO-LSTM prediction model,and then,the consumption of medical consumables was assessed.A total of 900 medical consumables which were clinically used in the Center of Endoscopy of Nanjing Tianyinshan Hospital Affiliated to China Pharmaceutical University from March to August 2024 were selected,and they were randomly divided into conventional management mode group(n=450 consumables)and PSO-LSTM management mode group(n=450 consumables)by random number table method,so as to conduct management for consumables.The management time,management timeliness,situation of monthly management of medical consumables,and predicted accuracy of consumption amount of medical consumables of two management mode in single diagnosis and treatment were compared.Results:The prepared time,delivered time,response time of temporary application,and the time of returning storehouse of medical consumables in PSO-LSTM model management mode were respectively(3.36±1.66),(9.54±2.69),(3.69±1.65)and(3.47±1.87)min,which were all less than those in conventional management mode,and the differences were statistically significant(t=7.76,13.811,28.147,39.105,P<0.05).The timeliness of supplementing medical consumables,shortage warning and proposing treatment methods of using PSO-LSTM model management mode were respectively(0.87±0.23),(3.26±0.87)and(14.98±2.65)min,which were all less than those of using conventional management mode,and the differences of them were statistically significant(t=4.228,15.482,13.420,P<0.05).In 450 medical consumables of the center of endoscopy,the amounts of the monthly average emergency purchasing and monthly average shortage were respectively 20 and 22 in using PSO-LSTM model management mode,accounting for 4.44%and 4.89%,all of which were lower than those of conventional management mode,and the differences of them were statistically significant(x2=10.364,11.835,P<0.05).The prediction results of using PSO-LSTM model management mode for disposable infusion device and disposable auxiliary kit of gastroscopy were closer to the actual consumption than the conventional management mode,while the differences of them were not significant(P>0.05).Conclusion:The application of the management mode of predictive model of medical consumables based on PSO-LSTM algorithm in the management of medical consumables of the center of endoscopy in hospital can accurately assess the consumption of medical consumables,and provide scientific basis for the procurement decision of medical consumables,and achieve fine management for various kinds of medical consumables,and reduce the cost of medical consumables in the center of endoscopy.

Guillain-Barre syndrome rarely develops after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and only a few reports exist in China. Guillain-Barre syndrome is an acute and life-threatening condition that requires early diagnosis and treatment. A patient with acute myeloid leukemia underwent allogeneic HSCT for >5 months and gradually developed limb muscle weakness and limited eye movement after coexisting with delayed acute intestinal graft-versus-host disease. After the examination of cerebrospinal fluid and electromyography, the diagnosis of Guillain–Barre syndrome was confirmed. After a high-dose intravenous immunoglobulin (IVIg) treatment, muscle strength gradually recovered, and the prognosis was good.

Humans ; East Asian People ; Surveys and Questionnaires ; Vitiligo/epidemiology*

Allografts ; COVID-19 ; China/epidemiology* ; Disease Outbreaks ; Humans ; Kidney Transplantation/adverse effects* ; SARS-CoV-2

Objective:To evaluate the effect of edaravone on long-term cognitive function in elderly patients undergoing hip replacement.Methods:A total of 160 patients, aged≥65 yr, undergoing elective hip replacement, were divided into 2 groups ( n=80 each) using the random sequence generated by the McLeod-modified Wichmann-Hill pseudo-random number generator: edaravone group (group E) and control group (group C). Spinal-epidural anesthesia was applied in two groups.Edaravone 60 mg (in 100 ml of normal saline, infusion rate 200 ml/h) was intravenously infused from the time point immediately after achieving the anesthesia plane until the following 30 min.Serum chemokine ligand 13 (CXCL13) and interleukin-6 (IL-6) concentrations were detected by enzyme-linked immunosorbent assay before anesthesia, during surgery (30 min after skin incision), and at postoperative days 1, 3 and 7.The Confusion Assessment Method Scale in Chinese was used to detect the postoperative delirium at postoperative days 1, 2, 3 and 7, and the Telephone Interview for Cognitive Status-Modified and ADL score were adopted to assess the cognitive function and quality of daily living, respectively, and the occurrence of cognitive impairment was recorded at 1 and 12 months after surgery. Results:Compared with group C, the total Telephone Interview for Cognitive Status-Modified score and ADL score were significantly increased, the incidence of postoperative delirium and cognitive impairment was decreased, and the serum CXCL13 and IL-6 concentrations were decreased during surgery and at each time point after surgery in group E ( P<0.05). Conclusion:Edaravone can reduce inflammatory responses and improve long-term cognitive function in elderly patients undergoing hip replacement.

Objective: To explore the relationship between anthropometric indices and the incident risk of hypertension, compare novel anthropometric indices with traditional indices in hypertension prediction and establish hypertension prediction models among elderly Chinese. Methods: A total of 27 009 retirees from the Dongfeng Motor Corporation were recruited at baseline in 2008 and the first follow-up was conducted in 2013. After the exclusion of participants less than 60 years old, participants with hypertension, coronary heart disease, stroke, cancer, and those with missing data, a total of 6 784 elderly participants were enrolled in this study. A multivariate logistic regression model was used to analyze the relationship between traditional anthropometric indices, body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), novel anthropometric indices, visceral adiposity index (VAI), body shape index (ABSI), body roundness index (BRI), and the incident risk of hypertension. Meanwhile, a multivariate logistic regression model was used to establish hypertension prediction models. Receiver operating characteristic (ROC) curve was applied to compare the prediction ability of different models. Results: A total of 1 787 incident cases of hypertension were identified, with the incidence of hypertension about 27.59%. Significant positive associations were detected between BMI, WC, WHtR, VAI, BRI and the incident risk of hypertension after adjusting for potential confounders (all P values<0.05). In men, the OR (95%CI) (upper tertile vs lower tertile) was 1.45 (1.22-1.73) for VAI, and 1.86 (1.55-2.23) for BRI. In women, the OR (95% CI) (upper tertile vs lower tertile) was 1.55 (1.22-1.96) for VAI, and 1.60 (1.27-2.01) for BRI. For ABSI, no significant association was observed in either men (OR (95%CI): 1.07 (0.90-1.28)) or women (OR (95%CI): 1.03 (0.82-1.29), both P values >0.05). The basic hypertension prediction model included age, drinking (only in men), education status (only in men), systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood glucose levels. Based on the basic prediction model, BMI (in men: AUC=0.697) and BRI (only in men: AUC=0.696) improved area under ROC curve (AUC) significantly (P<0.05). BMI was the strongest predictor in both men (AUC=0.697) and women (AUC=0.685) in the extended model. Conclusion Significant positive associations were detected between BMI, WC, WHtR, VAI, BRI and the incident risk of hypertension among elderly Chinese. BMI was the strongest predictor in hypertension prediction model compared with other anthropometric indices.

Objective To explore the value of diffusion weighted imaging (DWI) in combination with susceptibility weighted imaging (SWI) in prognosis prediction of traumatic axonal injury (TAI).Methods A retrospective study of 75 patients with TAI was performed to analyze the clinical data and the follow-up prognosis in the 6 months after injury.The detection rate of TAI lesion by DWI,SWI and conventional MRI was compared.Multiple factors analysis applied logistic regression analysis to analyze the relationship between associated factors and prognosis.Results The average detected TAI lesions were (19.92 ± 8.62) by DWI and (22.17 ± 11.72) by SWI,which had no significant differences (t=1.24,P＞0.05),but there was a significant difference bettween by conventional MRI and by DWI or SWI (all P＜0.05).DWI was more sensitive to non-hemorrhagic lesions and SWI was more sensitive to hemorrhagic lesions.However,the lesions revealed by them existed the overlap of location and pathology of lesions.Patients with poor outcomes had more number of central lesions than those patient with good outcomes (t=2.455,P＜ 0.05).Logistic regression analysis revealed that the predictive accuracy provided by the combination with imaging and clinical factors was 95.7 ％.Conclusions DWI and SWI both are sensitive to TAI lesions,and have ability to detect the lesions with different pathological characteristics,separately.Accurate prognosis prediction for patients with TAI may be provided by the combination of clinical and imaging factors.