Objective To understand the time change trend and epidemiological characteristics of occupational exposure of medical personnel in a general class A tertiary hospital in Shenzhen,and to provide practical guidance for occupational protec-tion management practice and optimization of occupational exposure prevention and control strategies.Methods The data of 813 cases of occupational exposure reported from 2017 to 2022 in our hospital were retrospectively investigated and analyzed,inclu-ding the basic information of exposure sources,exposed persons and exposure events.Results During 2017 to 2022,the number of occupational exposure cases showed a trend of first increase and then fluctuation,with the largest number of occupational expo-sure cases occurring in the third quarter and 8-11 o'clock of the day.Among the 813 cases of occupational exposure,569 were female(69.99％),nurses accounted for the highest proportion(391,48.09％),the number of people with 1-5 years of working life experienced occupational exposure was the highest(343,42.19％),and staff with junior professional titles accounted for the highest proportion(324,39.85％).Most were exposed for the first time(621,76.38％).Most of the occupational exposure occurred in the ward(301 cases,37.02％),82.41％was acute injuries,the upper limbs such as fingers,arms,etc.,the high-est exposure ratio(87.21％),most of the secondary exposure(49.45％).In 410 cases(50.43％),the primary sources of oc-cupational exposure were hepatitis B(255 cases,62.20％)and syphilis(119 cases,29.02％).Conclusion The key to effec-tively reduce the occurrence of occupational exposure and its adverse consequences is to implement key management for key groups,key places and key times,emphasize the importance of occupational safety education,and actively carry out relevant training and emergency drills.

Objective To understand the time change trend and epidemiological characteristics of occupational exposure of medical personnel in a general class A tertiary hospital in Shenzhen,and to provide practical guidance for occupational protec-tion management practice and optimization of occupational exposure prevention and control strategies.Methods The data of 813 cases of occupational exposure reported from 2017 to 2022 in our hospital were retrospectively investigated and analyzed,inclu-ding the basic information of exposure sources,exposed persons and exposure events.Results During 2017 to 2022,the number of occupational exposure cases showed a trend of first increase and then fluctuation,with the largest number of occupational expo-sure cases occurring in the third quarter and 8-11 o'clock of the day.Among the 813 cases of occupational exposure,569 were female(69.99％),nurses accounted for the highest proportion(391,48.09％),the number of people with 1-5 years of working life experienced occupational exposure was the highest(343,42.19％),and staff with junior professional titles accounted for the highest proportion(324,39.85％).Most were exposed for the first time(621,76.38％).Most of the occupational exposure occurred in the ward(301 cases,37.02％),82.41％was acute injuries,the upper limbs such as fingers,arms,etc.,the high-est exposure ratio(87.21％),most of the secondary exposure(49.45％).In 410 cases(50.43％),the primary sources of oc-cupational exposure were hepatitis B(255 cases,62.20％)and syphilis(119 cases,29.02％).Conclusion The key to effec-tively reduce the occurrence of occupational exposure and its adverse consequences is to implement key management for key groups,key places and key times,emphasize the importance of occupational safety education,and actively carry out relevant training and emergency drills.

Objective    To summarize the clinical experience of surgical resection of synchronous multiple ground-glass nodules (SMGN), and explore the individualized diagnosis and treatment strategy of SMGN. Methods    Clinical data of 84 patients with SMGN who underwent thoracic surgery in Anhui Chest Hospital from July 2016 to August 2018 were analyzed retrospectively, including 18 males (21.4%) and 66 females (78.6%), aged 32-80 (55.6±10.3) years. The results of operation and the information of GGNs were analyzed. Results    Except for 1 patient who was converted to thoracotomy due to extensive dense adhesion of thoracic, other patients underwent video-assisted thoracoscopic surgery successfully. All patients recuperated successfully after operation, without severe perioperative complications or death. Finally, 79 patients were diagnosed as malignant tumors (94.0%), and 5 patients of benign lesions (6.0%). A total of 240 GGNs were removed, among which there were 168 pGGNs, including 68 benign lesions (40.5%) and 100 malignant tumors (59.5%), and 72 mGGNs, including 2 benign nodules (2.8%) and 70 malignant tumors (97.2%). Nodules diameter (P<0.001), consolidation/maximum diameter of nodule ratio (P<0.001), vacuole sign (P<0.001), air bronchograms sign (P=0.001), spine-like process (P=0.001), pleural indentation sign (P<0.001), lobulation sign (P<0.001), and vascular convergence (P=0.002) were correlated with malignant tumor. Conclusion    Analysis of the imaging features of GGNs by thin-section CT scan and three-dimensional reconstruction is of great value in predicting the benign and malignant nodules, which can guide the surgical decision-making and preoperative planning. Through reasonable preoperative planning and following certain principles, simultaneous surgical treatment for SMGN is safe and feasible.

Objective To determine the diagnostic value and necessity of excretory phase of CT urogrphy (CTU). Methods One hundred and one cases with 197 sides of cohort CTU studies were enrolled from PACS system retrospectively, and 44 cases had the records of radiation dosage. Three different seniority senior radiologists reviewed the images and diagnosed 2 times blindly with the clinical information. At the first time, plane scan, contrast enhanced renal cortical phase and renal parenchymal phase images (Diag. A) were reviewed. At the second time, with 3 kinds of images mentioned above plus excretive phase images (Diag. B) were reviewed, with interval of 3 months between the two reviews. With Diag. B as reference standard, accordance rate of diagnoses of Diag. A was calculated. The difference of the 3 rediologists's accordance rates were analyzed with Chi-square test, and the lesions with accordance rate ≤80% were recorded. The cases of 197 urinary tracts were divided into 4 groups: lesions of renal pelvic and ureter, lesions of bladder, lesions of kidney and extra-urinary tract, without lesion. The filling of contrast media in the urinary tract was recorded with 5-scale scoring system. The differences of the urinary tract filling among the 4 groups were analyzed with Kruskal-Wallis test. The effective radiation dosages of CTU with and without excretory phase scan were recorded and calculated, and the difference was analyzed with t test. Result The diagnostic accordance rate of CTU with and without excretory phase of the 3 radiologists was 95.4%(188/197), 93.9%(185/197), 92.4%(182/197)respectively(χ2=1.60, P>0.05). Lesions with diagnostic rate≤80%were parapelvic cyst and caliceal diverticulum. The median score of urinary tracts filling in the lesions of renal pelvic and ureter, lesions of bladder, lesions of kidney and extra-urinary tract, without lesion group were 2, 3, 3, 4, and the differences were significant (HC=31.7, P<0.05). The effective radiation dosages of CTU with and without excretory phase scan were (32.36±11.04)mSv and (41.47±14.27) mSv respectively (t=3.35, P<0.01). Conclusions No significant effect of excretive phase imaging is found on the diagnosis of most urinary system diseases. Poor contrast filling and high rate of failure of filling of the urinary tract with intra luminal pathologies, and increase of the radiation dosage make the excretory phase scan in CTU less useful and it should be used carefully and selectively.

Objective To study the effects of Xianlingqianggukoufuye (XLQGKFY) on postmenopausal osteoporosis in ovariectomized female rats. Method 60 female Sprague-dawley rats in 7-month were used, 50 of them were ovariectomized and randomly divided into 5 groups:ovariectomized (OVX), OVX+ Nylestriol, OVX+XLQGKFY (high dose, middle dose, low dose), the others were sham-operated group. Rats were treated with drugs starting at 3rd day after the operation for 90 days. Double in vivo fluorochrome labeling was administered to all rats. At the end-point of study, the blood was collected to detecte contents of ALP, StrACP in serum, the fourth lumar vertebra (LV4) and femur bone sections were cut and stained for bone histomorphometric analyses, biomechanical analyses and BMP analyses. Result XLQGKFY decreased greatly the StrACP content, increased bone stiffness, bone M-load, improved bone biomechanical property. Conclusion XLQGKFY has a good preventive effect on postmenopausal osteoporosis which provides for clinical use.