Objective:To investigate the correlation and its clinical significance between the ratio of non-high density lipoprotein cholesterol to high density lipoprotein cholesterol (non-HDL-C/HDL-C) and subclinical arteriosclerosis (SA) in officers and seamen of naval special duty.Methods:A total of 118 officers and seamen of naval special duty with SA admitted to Xiamen Special Services Recuperation Center of the Army from June 2015 to June 2018 were selected as SA group. According to the carotid intima-media thickness (C-IMT) and plaque occurrence, they were divided into two subgroups: 60 cases in thickening group and 58 cases in plaque group. And another 60 officers and seamen of naval special duty admitted in the sanatorium in the same period for resting were selected into control group as they were healthy after examination. Routine physical examination recordings were compared among those groups, including general clinical data (cardiovascular health behavioral factors score, C-IMT, and blood glucose) and recordings on lipid [triglyceride (TG), total cholesterol (TC), HDL-C, low density lipoprotein cholesterol (LDL-C), non-HDL-C, non-HDL-C/HDL-C ratio, and atherogenic index of plasma (AIP)]. C-IMT and AIP were analyzed by correlation and multiple linear regression, and carotid plaque occurrence was analyzed by binary logistic regression.Results:①Among the control group, the thickening group, and the plaque group, variance analysis showed that TG, TC, LDL-C, non-HDL-C, AIP, non-HDL-C/HDL-C, C-IMT increased in turn significantly, while HDL-C, exercise score, and healthy diet score decreased in turn significantly ( P<0.05 or P<0.01). ②Correlation analysis showed that there was a positive correlation of non-HDL-C/HDL-C with C-IMT and AIP, respectively ( P<0.01 or P<0.05). ③Regression analysis showed that non-HDL-C/HDL-C entered the regression model with C-IMT and AIP as dependent variables ( P<0.01), and did not enter the regression model with common carotid artery plaque as the dependent variable ( P>0.05). Conclusion:There is obvious abnormal lipid metabolism in officers and seamen of naval special duty with SA. Non-HDL-C/HDL-C is positively correlated with C-IMT and AIP, which is a risk factor of officers and seamen of naval special duty with SA and can be used as a good index for evaluating officers and seamen of naval special duty with SA. Among the officers and seamen of naval special duty, the control of lipid should be focused on.

Objective:To investigate the correlation and its clinical significance between the ratio of non-high density lipoprotein cholesterol to high density lipoprotein cholesterol (non-HDL-C/HDL-C) and subclinical arteriosclerosis (SA) in officers and seamen of naval special duty.Methods:A total of 118 officers and seamen of naval special duty with SA admitted to Xiamen Special Services Recuperation Center of the Army from June 2015 to June 2018 were selected as SA group. According to the carotid intima-media thickness (C-IMT) and plaque occurrence, they were divided into two subgroups: 60 cases in thickening group and 58 cases in plaque group. And another 60 officers and seamen of naval special duty admitted in the sanatorium in the same period for resting were selected into control group as they were healthy after examination. Routine physical examination recordings were compared among those groups, including general clinical data (cardiovascular health behavioral factors score, C-IMT, and blood glucose) and recordings on lipid [triglyceride (TG), total cholesterol (TC), HDL-C, low density lipoprotein cholesterol (LDL-C), non-HDL-C, non-HDL-C/HDL-C ratio, and atherogenic index of plasma (AIP)]. C-IMT and AIP were analyzed by correlation and multiple linear regression, and carotid plaque occurrence was analyzed by binary logistic regression.Results:①Among the control group, the thickening group, and the plaque group, variance analysis showed that TG, TC, LDL-C, non-HDL-C, AIP, non-HDL-C/HDL-C, C-IMT increased in turn significantly, while HDL-C, exercise score, and healthy diet score decreased in turn significantly ( P<0.05 or P<0.01). ②Correlation analysis showed that there was a positive correlation of non-HDL-C/HDL-C with C-IMT and AIP, respectively ( P<0.01 or P<0.05). ③Regression analysis showed that non-HDL-C/HDL-C entered the regression model with C-IMT and AIP as dependent variables ( P<0.01), and did not enter the regression model with common carotid artery plaque as the dependent variable ( P>0.05). Conclusion:There is obvious abnormal lipid metabolism in officers and seamen of naval special duty with SA. Non-HDL-C/HDL-C is positively correlated with C-IMT and AIP, which is a risk factor of officers and seamen of naval special duty with SA and can be used as a good index for evaluating officers and seamen of naval special duty with SA. Among the officers and seamen of naval special duty, the control of lipid should be focused on.

Objective To detect the role of surviving (SVV) in the protective effect of resveratrol against hypoxia/reperfusion injury (H/RI) of cardiac microvascular endothelial cells (CMECs).Methods CMECs isolated from the hearts of adult rats were exposed to hypoxia (94％ N2,5％ CO2,1％ O2) for 2 h followed by 4 h reoxygenation (95％ O2,5％ CO2).The cell proliferation of CMECs was measured by MTT assay and Transwell method was used to detect migration ability of CMEC,PI-AnnexinV double staining and flow cytometry technique were employed to observe the apoptotic rate of CMECs.The SVV protein expression was detected with Western blot method.Results Compared to control group,the proliferation (0.19 ± 0.03vs.0.42 ±0.07,P ＜0.01) and migration ((28 ± 2)/5HPF vs.(50 ±3)/5 HPF,P ＜0.01) abilities were impaired and the apoptosis index ((19.7 ± 0.8) ％ vs.(5.4 ± 0.3) ％,(P ＜ 0.05) of CMEC was increased after H/RI.The proliferation (0.36 ± 0.07 vs.0.19 ± 0.03,P ＜ 0.05) and migration ((55 ± 3)/5 HPF vs.(28 ± 2)/5 HPF,P ＜ 0.05) abilities of CMEC were significantly improved while the apoptosis index ((9.6 ±0.7) ％ vs.(19.7 ± 0.8) ％,P ＜ 0.05) was significantly decreased in H/RI + resveratrol group compared to H/RI group.SVV protein expression was also upregulated in H/RI + resveratrol group compared to H/RI group (P ＜0.05).To further ascertain the role of SVV in the protective effects of resveratrol,PI3K specific inhibitor LY294002 was added to H/RI + resveratrol group,the proliferation(0.25 ± 0.05 vs.0.36 ± 0.07,P ＜0.05) and migration ((34 ± 3)/5HPF vs.(55 ± 3)/5HPF,P ＜ 0.05) abilities were significantly decreased,the apoptosis index ((16.2 ± 0.6) ％ vs.(9.6 ± 0.7) ％,P ＜ 0.05) was increased and the protein expression of SVV was downregulated (P ＜ 0.05) in LY294002 + H/RI + resveratrol group compared to H/RI + resveratrol group.Conclusion Resveratrol could significantly reduce H/RI induced apoptosis and attenuate H/RI induced cardiac microvascular endothelial cells dysfunction through up-regulating PI3K/Akt/SVV pathways.