ObjectiveTo explore the current status and issues regarding the application of ancient books in clinical practice guidelines and expert consensus of traditional Chinese medicine （TCM） published in China， and to provide methodological recommendations for the incorporation of ancient books in the development of TCM guidelines. MethodsWe searched China National Knowledge Infrastructure （CNKI）， WanFang Data， VIP， SinoMed， PubMed， Embase， as well as six industry websites including China Association of Chinese Medicine， National Group Standards Information Platform， and Chinese Association of the Integration of Traditional and Western Medicine，etc. TCM clinical practice guidelines or expert consensus issued during January 1st， 2017， to November 26th， 2022 were searched. Clinical practice guidelines or expert consensus that explicitly referred to ancient books were included， and the content regarding the searching for ancient books， sources of access to ancient books， methods of evaluating the level of evidence， methods of evaluating the level of recommendation， and methods of evaluating the evidence for the ancient books were analysed. ResultsA total of 1,215 TCM clinical practice guidelines or expert consensus were retrieved， with 442 articles explicitly mentioning the application of ancient books， including 300 （67.87%） clinical practice guidelines and 142 （32.13%） expert consensus. Sixty of the 442 publications explicitly reported that ancient books searching had been conducted （13.57%）； among these 60 publications 27 （45.00%） explicitly reported ancient books searching strategies， and the most frequent method was manual searching with a total of 24 articles （40.00%）. The most popular search source was Chinese Medical Dictionary， a TCM classics database， with a total of 18 articles. 197 articles （44.57%） explicitly reported the evaluation criteria for the level of evidence， of which 141 articles （71.57%） involved the evaluation criteria for the ancient books； 413 articles （93.44%） mentioned ancient books in the recommendations， and only the source of formula name was mentioned in 409 （99.03%） of the publications. ConclusionThe current application of ancient books in TCM clinical practice guidelines and expert consensus is limited， with issues of non-standard searching and evaluation methods. Standar-dization and uniformity are needed in evidence grading and recommendation standards. Future research should clarify the scope and methods of applying ancient book， emphasize their integration with modern research evidence， and enhance their value and quality in the development of TCM clinical practice guidelines.

Objective:To investigate the risk factors, pregnancy outcomes of intrauterine pregnancy with tubal pregnancy after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods:The study was a retrospective case-control study that collected clinical data of patients diagnosed with intrauterine combined with tubal pregnancy after IVF/ICSI for infertility at Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital from January 2009 to December 2021. The study group consisted of patients diagnosed with intrauterine combined with tubal pregnancy after IVF/ICSI and treated with surgery ( n=91). The control group consisted of patients diagnosed with early intrauterine pregnancy after IVF/ICSI in a 1∶4 ratio during the same period ( n=364). General information, assisted reproduction and pregnancy-related data of the two groups were analyzed, and risk factors for intrauterine combined with tubal pregnancy after IVF/ICSI were determined through univariate and logistic analyses. Furthermore, the study group was divided into two subgroups according to different pregnancy outcomes, miscarriage and live birth, and risk factors that may affect pregnancy outcomes of patients with intrauterine combined with tubal pregnancy were analyzed between the two subgroups. Results:There were no significant differences in age, body mass index, gestational times, basal hormone levels, endometrial thickness before transplantation and human chorionic gonadotropin level after transplantation between the study group and control group (all P>0.05). The live birth rate of the two groups was similar ( P>0.05). A history of ectopic pregnancy ( OR=2.605, 95% CI: 1.352-5.016, P=0.004) and hydrosalpinx ( OR=26.012, 95% CI: 2.942-229.974, P=0.003) were risk factors for intrauterine combined with tubal pregnancy after IVF/ICSI. Patients with intrauterine combined with tubal pregnancy were divided into live birth subgroup and abortion subgroup. There were no significant differences in the proportion of abdominal pain, uterine hemoperitoneum and other symptoms between the two subgroups (all P>0.05), and there were no statistical differences in operation time, gestational age and intraperitoneal hemorrhage between the two subgroups (all P>0.05). Vaginal bleeding after transplantation ( OR=3.128, 95% CI: 1.067-9.172, P=0.038) in the abortion subgroup may be a risk factor for miscarriage in intrauterine combined with tubal pregnancy. Conclusion:Live birth rate in intrauterine pregnancy combined with tubal pregnancy patients after surgery was similar with patients with normal intrauterine pregnancy. Ectopic pregnancy history and hydrosalpinx may be risk factors for patients with intrauterine pregnancy combined with tubal pregnancy after IVF/ICSI, and vaginal bleeding after transplantation may be a high risk factor for abortion in those patients.

Objective:To investigate the risk factors, pregnancy outcomes of intrauterine pregnancy with tubal pregnancy after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods:The study was a retrospective case-control study that collected clinical data of patients diagnosed with intrauterine combined with tubal pregnancy after IVF/ICSI for infertility at Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital from January 2009 to December 2021. The study group consisted of patients diagnosed with intrauterine combined with tubal pregnancy after IVF/ICSI and treated with surgery ( n=91). The control group consisted of patients diagnosed with early intrauterine pregnancy after IVF/ICSI in a 1∶4 ratio during the same period ( n=364). General information, assisted reproduction and pregnancy-related data of the two groups were analyzed, and risk factors for intrauterine combined with tubal pregnancy after IVF/ICSI were determined through univariate and logistic analyses. Furthermore, the study group was divided into two subgroups according to different pregnancy outcomes, miscarriage and live birth, and risk factors that may affect pregnancy outcomes of patients with intrauterine combined with tubal pregnancy were analyzed between the two subgroups. Results:There were no significant differences in age, body mass index, gestational times, basal hormone levels, endometrial thickness before transplantation and human chorionic gonadotropin level after transplantation between the study group and control group (all P>0.05). The live birth rate of the two groups was similar ( P>0.05). A history of ectopic pregnancy ( OR=2.605, 95% CI: 1.352-5.016, P=0.004) and hydrosalpinx ( OR=26.012, 95% CI: 2.942-229.974, P=0.003) were risk factors for intrauterine combined with tubal pregnancy after IVF/ICSI. Patients with intrauterine combined with tubal pregnancy were divided into live birth subgroup and abortion subgroup. There were no significant differences in the proportion of abdominal pain, uterine hemoperitoneum and other symptoms between the two subgroups (all P>0.05), and there were no statistical differences in operation time, gestational age and intraperitoneal hemorrhage between the two subgroups (all P>0.05). Vaginal bleeding after transplantation ( OR=3.128, 95% CI: 1.067-9.172, P=0.038) in the abortion subgroup may be a risk factor for miscarriage in intrauterine combined with tubal pregnancy. Conclusion:Live birth rate in intrauterine pregnancy combined with tubal pregnancy patients after surgery was similar with patients with normal intrauterine pregnancy. Ectopic pregnancy history and hydrosalpinx may be risk factors for patients with intrauterine pregnancy combined with tubal pregnancy after IVF/ICSI, and vaginal bleeding after transplantation may be a high risk factor for abortion in those patients.

This study delves into the pivotal factors influencing the consensus process within traditional Chinese medicine guideline development, with the objective of augmenting the quality of this process through methodological recommendations aimed at elevating standardization.

Objective:To analyze the clinical features and prognostic risk factors of female patients with acute myo‐cardial infarction (AMI) .Methods :From Apr 2011 to Oct 2014 ,a total of 97 female AMI patients treated in our hospital were enrolled as female group ,meanwhile 120 male AMI patients were regarded as control group (male group) .All patients received three‐month follow‐up after hospitalization .Baseline data ,clinical features and prog‐nosis were compared between two groups ,and prognostic risk factors of female patients were analyzed at the same time .Results:Compared with male group ,there were significant rise in percentages of cardio‐and cerebrovascular diseases ,diabetes mellitus and hyperlipidemia ,and significant reductions in red blood cell count ,hemoglobin level , and percentages of smoking&drinking history , digestive&urinary system diseases in female group , P<0.05 or <0.01. Compared with male group , there were significant rise in percentages of Killip class Ⅳ (14.17% vs . 24.74% ) ,three‐vessel coronary disease (3.33% vs . 12.37% ) , therapeutic rate of reperfusion (51.67% vs . 73.20% ) ,mortality (2.50% vs .9.28% ) and incidence of complications (19.17% vs .31.96% ) in female group ,P<0.05 all .Logistic analysis of regression showed that age ,previous cardio‐ and cerebrovascular diseases ,diabetes mellitus ,hyperlipidemia ,Killip cardiac function class and number of diseased coronary vessels were significantly cor‐related with prognosis (OR=0.176~4.931 , P<0.05 all) .Conclusion:Prognosis of female AMI patients is poorer than that of males .Prognosis is related to age ,cardio‐ and cerebrovascular diseases ,diabetes mellitus ,hyperlipi‐demia ,Killip cardiac function class ,and number of diseased coronary vessels .