Endothelial dysfunction(ED)is a crucial pathological feature and a key initiating factor in diabetic angiopathy.A major pathway contributing to ED is the reduction of nitric oxide(NO)production.NO is synthesized by endothelial nitric oxide synthase(eNOS)using L-arginine as a substrate.However,arginase(Arg)can compete with eNOS for this substrate.Arg has subtype 1 and 2.In diabetes mellitus(DM),the abnormal increase in Arg1 can lead to excessive consumption of the substrate in the vascular endothelium,which causes a decrease in NO levels,leading to diabetes-induced vascular ED.This article reviews the research progress of arginase 1 in diabetes-induced vascular ED.

Endothelial dysfunction(ED)is a crucial pathological feature and a key initiating factor in diabetic angiopathy.A major pathway contributing to ED is the reduction of nitric oxide(NO)production.NO is synthesized by endothelial nitric oxide synthase(eNOS)using L-arginine as a substrate.However,arginase(Arg)can compete with eNOS for this substrate.Arg has subtype 1 and 2.In diabetes mellitus(DM),the abnormal increase in Arg1 can lead to excessive consumption of the substrate in the vascular endothelium,which causes a decrease in NO levels,leading to diabetes-induced vascular ED.This article reviews the research progress of arginase 1 in diabetes-induced vascular ED.