Objective To analyze the related factors of postoperative quality of life in patients with acromegaly.Methods Forty-one patients with acromegaly diagnosed in People's Hospital of Xinjiang Uygur Autonomous Region from January 2013 to May 2022 and followed up for 3 months after pituitary adenoma resection were selected as subjects to collect their general basic data and biochemical indexes.AcroQoL and SF-12 scale were used to score the quality of life of all patients,and the factors affecting the quality of life after operation were analyzed.Results In the AcroQOL scale,age,education level and the time from the onset of symptoms to operation were positively correlated with psychological score(P<0.05).In the AcroQOL scale,the level of education was positively correlated with the total score and the score of mental appearance(P<0.05).There was a positive correlation between age and the score of psychological interpersonal relationship of AcroQoL scale(P<0.05),and the type of occupation affected the score of SF-12 scale(P<0.05).In the AcroQOL scale,the total score,physiological score,and psychological score of the biochemical remission group were better than those of the biochemical non-remission group(P<0.05,P<0.01,P<0.05).In the SF-12 scale,the body score of the biochemical remission group was better than that of the biochemical non-remission group(P<0.01).The preoperative insulin like growth factor 1(IGF-1)level was negatively correlated with the psychological score(P<0.05).In the SF-12 scale,the preoperative growth hormone level level was positively correlated with the physiological and psychological scores(P<0.05),and the second operation was a negative factor affecting the SF-12 score(P<0.05).The number of complications had a negative effect on the scores of all dimensions of the AcroQoL scale(P<0.05).In the scatter plot,with the increase of the level of IGF-1 before operation,the score of the AcroQoL scale showed a downward trend(P<0.05),but had nothing to do with the score of SF-12 scale(P>0.05).The size of pituitary adenoma is a negative factor affecting the psychological score of SF-12 scale(P<0.05).Conclusion Age,occupation,education level,secondary operation,complication quan-tity,radio therapy,size of pituitary adenoma,and the time from the onset of symptoms to operation all affect the postoperative quality of life of patients with acromegaly.Biochemical remission can partially improve,but not completely reverse the postoperative quality of life of patients.