1.Spontaneous haemorrhage- Is imatinib the cause?
Dhanya RAMACHANDRAN ; Saravanan THANGAVELU
Brunei International Medical Journal 2013;9(1):6-66
Imatinib, a tyrosine kinase-C protein inhibitor remains the first choice for the management of chronic
myeloid leukaemia (CML) since its introduction over a decade ago. Intracranial and gastrointestinal
haemorrhages have been previously reported in association with Imatinib therapy. We report the case
of a 47-yr-old man who was recently diagnosed with chronic phase of CML, that was complicated by a
spontaneous intramuscular haematoma in the left gluteal region after 10 days of treatment with
Imatinib. To the best of our knowledge, an intramuscular haemorrhage has not been described so far in
association with Imatinib therapy. Clinicians should be alert to the possibility of spontaneous haemor-
rhage at unusual sites in patients being treated with Imatinib.
2.Churg-Strauss Syndrome in an elderly man
Saravanan THANGAVELU ; Dhanya RAMACHANDRAN
Brunei International Medical Journal 2013;9(4):266-269
Churg-Strauss Syndrome (CSS) is an uncommon systemic vasculitis affecting the medium and small sized arteries. CSS was earlier considered fatal, but prognosis has significantly improved with the use of steroids and other immunosuppressive therapy. CSS has been reported in patients as young as seven years old to as old as 74 but generally occurs in the third to fifth decade of life. Here we describe an 86-year-old Indian man who was affected by this disease with clinical presentations as described in younger individuals and excellent response to therapy. To our best knowledge, presentation at so late an age has not been documented in the literature.
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