Objective To explore influencing factors for disease control in children with bronchial asthma treated by budesonide formoterol inhalant.Methods Clinical data of 80 children with bronchial asthma admitted to Suqian First Hospital from January 2019 to January 2022 were retrospectively analyzed.All the children were treated with budesonide formoterol inhalant.The disease control level was evaluated by the childhood asthma control test questionnaire after 12-week treatment.According to the scores,the children were divided into complete control group(>25,33 cases),partial control group(22-25,35 cases)and uncontrolled group(<22,12 cases).The gender,age,body mass index(BMI),positive result of allergen skin prick test(SPT),severity of illness,allergic constitution,educational level of the family,family history of asthma,and the percentage of forced expiratory volume in one second in estimated value(FEV1%pred)were compared among groups.Multivariate Logistic regression analysis was used to identify independent risk factors for poor disease control in children with bronchial asthma treated by budesonide formoterol inhalant.Results There were significant differences among the three groups in the severity of illness,allergic constitution,and FEV1%pred(P<0.05).Multivariate Logistic regression analysis confirmed that moderate to severe disease severity,allergic constitution and FEV1%pred≤82.695%were independent risk factors for poor disease control in children with bronchial asthma treated by budesonide formoterol inhalant.(P<0.05).Conclusion Moderate to severe disease severity,allergic constitution and FEV1%pred≤82.695%are risk factors for poor disease control in children with bronchial asthma treated by budesonide formoterol inhalant.Different interventions should be given according to different conditions so as to improve disease control in children with bronchial asthma.

Apoptosis ; Autophagy ; Ferroptosis ; Iron/metabolism* ; Sequestosome-1 Protein/metabolism* ; Ubiquitin-Specific Proteases/metabolism*