Background: In the modern era, information technology has become an integral component of the healthcare sector, increasingly requiring healthcare providers to possess basic computer literacy and information technology skills to effectively manage and utilize care delivery technologies. With the rapid digitalization of health information systems across all levels of healthcare facilities, there has been a transition toward electronic platforms, where comprehensive patient data are entered into databases and managed through digital applications. Consequently, the delivery of nursing care through electronic systems and technologies has placed growing demands on nurses to develop strong informatics skills and competencies. Aim: To describe the informatics competency of nurses in Mongolia. Materials and Methods: A cross-sectional design was used for the study. Data were collected from 233 nurses who use information technology. Study setting was taken from three hospitals including National Center for Traumatology and Orthopedics (NCTO), National Center for Communicable Diseases (NCCD), Ulaanbaatar Railway Hospital by using convenience sampling method. The self-assessment of Nursing Informatics Competency instrument for evaluating the informatics competence of nurses has 48 questions and is rated on a 1-4 Likert scale. Descriptive statistics, correlation analysis and multiple linear regression analysis were calculated using SPSS-25.0 Result: The quality of life among those with breast cancer was at a moderate level with the mean overall score of 58.8 (SD=13.08). The results of this study shown that the average age of subjects as (36±9.4) and 31.3% of participants were 20-29 years old. The majority of the subjects were 73.4% (n=171) use the computer several times a day, and 81.5% (n=190) use the computer more than 2 hours a day. 51.1% of nurses’ informatics skills are relatively good. Multiple linear regression analysis revealed that age (β=–0.287, p=0.032) and computer use (β=–0.156, p=0.017) were significant predictors of total informatics competency among nurses. Increasing age was associated with a decrease in informatics competency scores. Other variables including gender, years of experience, education level, professional rank, and computer utilization were not statistically significant predictors. Conclusion The level of nurses’ informatics competency was determined to be 51.1%. Age and computer usage were identified as significant factors influencing nurses’ informatics competency.