Background : Physiologic pancreatic response to glucose load yields two peaks of insulin secretion: the first peak within 30 mins. , and the second to 3rd hour after the stimulus .Objective: Our aim to show that a combination therapy designed to mimic this insulin secretion obtains optimal glycemic control with sustainability Methods : in this descriptive retrospective study , we measured glycemic control and sustainability in terms of reduction in HbA1c and postprandial capillary blood glucose (pCBG) between patients on insulin 70/30 with lispro and insulin 70/30 alone . We reviewed records of 218 patients (153 females ; 65 males ) in outpatient endocrinology clinic . Initial and follow-up pCBG (2 to 4hours after lunch ) and HbA1c were measured and compared among study groups . Metformin 1000 to 1500 mg daily was given in combination with insulin .Conclusion: Combination insulin therapy with 70/30 and lispro mimicking physiologic insulin secretion yielded sustainability of glycemic in control (18% HbA1c reduction ) in type 2DM patients
Combination Insulin ; Lispro