ObjectiveTo explore the therapeutic effect of Xuebijing injection （XBJ） on severe acute pancreatitis induced acute lung injury （SAP-ALI） by regulating formyl peptide receptors （FPRs）/nucleotide-binding oligomerization domain-like receptor 3 （NLRP3） inflammatory pathway. MethodsSixty rats were randomly divided into a sham group， a SAP-ALI model group， low-， medium-， and high-dose XBJ groups （4， 8， and 12 mL·kg^-1）， and a positive drug （BOC2， 0.2 mg·kg^-1） group. For the sham group， the pancreas of rats was only gently flipped after laparotomy， and then the abdomen was closed， while for the remaining five groups， SAP-ALI rat models were established by retrograde injection of 5% sodium taurocholate （Na-Tc） via the biliopancreatic duct. XBJ and BOC2 were administered via intraperitoneal injection once daily for 3 d prior to modeling and 0.5 h after modeling. Blood was collected from the abdominal aorta 6 h after the completion of modeling， and the expression of interleukin （IL）-1β， IL-6， and tumor necrosis factor-α （TNF-α） in plasma was measured by enzyme-linked immunosorbent assay （ELISA）. The amount of ascites was measured， and the dry-wet weight ratios of pancreatic and lung tissue were determined. Pancreatic and lung tissue was taken for hematoxylin-eosin （HE） staining to observe pathological changes and then scored. The protein expression levels of FPR1， FPR2， and NLRP3 in lung tissue were detected by the immunohistochemical method. Western blot was used to detect the expression of FPR1， FPR2， and NLRP3 in lung tissue. Real-time fluorescence quantitative polymerase chain reaction （Real-time PCR） was used to detect the mRNA expression of FPR1， FPR2， and NLRP3 in lung tissue. ResultsCompared with the sham group， the SAP-ALI model group showed significantly decreased dry-wet weight ratio of lung tissue （P<0.01）， serious pathological changes of lung tissue， a significantly increased pathological score （P<0.01）， and significantly increased protein and mRNA expression levels of FPR1， FPR2， and NLRP3 in lung tissue （P<0.01）. After BOC2 intervention， the above detection indicators were significantly reversed （P<0.01）. After treatment with XBJ， the groups of different XBJ doses achieved results consistent with BOC2 intervention. ConclusionXBJ can effectively improve the inflammatory response of the lungs in SAP-ALI rats and reduce damage. The mechanism may be related to inhibiting the expression of FPRs and NLRP3 in lung tissue， which thereby reduces IL-1β and simultaneously antagonize the release of inflammatory factors IL-6 and TNF-α.

Based on the theory of the five-body constituents from Huangdi Neijing (Yellow Emperor's Internal Classic), the approach and methods of acupuncture for facial aging are explored. Acupuncture for facial aging can be guided by the concept of the five-body constituents, targeting the facial "skin, flesh, vessels, tendons, and bones", and utilizing five different types of needles-facial needles, needle knives, filiform needles, retaining needles, and elongated needles and filiform needles-to maximize their respective advantages in treating facial aging. Facial needles are applied to the "skin" by selecting facial acupoints or local ashi points (at wrinkle or pigmentation sites). Needle knives are used for the "flesh" to perform longitudinal dredging and transverse dissection of the facial muscle layers. Filiform needles target the "vessels" with needling at Renying (ST9) to improve facial complexion. Retaining needles act on the "tendons" with needling from Taiyang (EX-HN5) to Xiaguan (ST7), and Jiache (ST6) to Daying (ST5), using clockwise twisting to generate a retaining needle sensation and lifting to achieve an overall facial lifting effect.
Humans ; Acupuncture Therapy/methods* ; Face ; Skin Aging ; Acupuncture Points ; Aging

Objective:To study the time evolution of financing burden and discuss the feasibility of provincial pooling by analyzing the panel data of"individual contribution burden ratio"and"government subsidy burden ratio"of residents'medical insurance in Shandong Province from 2015 to 2022.Methods:Spatial auto-correlation was used to analyze the spatial agglomeration and heterogeneity pattern;convergence analysis was used to analyze the inter-annual trends in the economic burden.Results:The"out-of-pocket ratio"increased year by year and the difference among cities was significant,the Moran's I value decreased year by year,and the geographical distribution pattern showed a random distribution pattern;the"government subsidy burden ratio"had little difference among cities,the global Moran's index value increased year by year,and the spatial agglomeration pattern was enhanced;both of them had σ convergence and absolute β convergence,showing a trend of balanced development.Conclusion:In order to promote provincial-level coordination,safeguard fund security and reduce the burden on residents,economic synergistic development strategies have been adopted to raise residents'incomes;emphasis has been placed on cutting back on income and expenditure,fine-tuning fund supervision;and reforming the financing mechanism,formulating fine-tuning financing standards and focusing on the increase in the cost of disease prevention and control have been adopted,so as to provide references for the improvement of the health insurance system and the promotion of the sustainable development of the health insurance cause.

Objective:To analyze the status quo and influencing factors of the equity,accessibility and sustainability of the development of medical insurance for urban and rural residents in 2021,and provide a reference for improving the management and service level of medical insurance.Methods:Firstly,the"evaluation index system of medical insurance for urban and rural residents"was constructed,and the total index of the development level of medical insurance and its three subsystem indexes of equity,accessibility and sustainability were calculated.Secondly,the Theil index was used to measure the level differences of the three major regions in the east,central and west,and the spatial auto-correlation was used to analyze the spatial agglomeration and heterogeneity distribution pattern of the total index.Finally,a geographic weighted regression model was constructed to analyze the main influencing factors.Results:There were provincial differences in the development level of medical insurance,which showed a decreasing trend from east to west in geography and a random distribution pattern in space.Policy factors,economic factors,population structure,medical resource allocation and education level had a significant impact on the development level of medical insurance.Conclusions:It is proposed to promote the fairness at multiple levels,enhance the accessibility in all directions and dynamically improve the sustainability,and further explore the policy suggestions to improve the management and service level and enhance the residents'sense of experience,sense of gain and sense of happiness.

Objective:To study the time evolution of financing burden and discuss the feasibility of provincial pooling by analyzing the panel data of"individual contribution burden ratio"and"government subsidy burden ratio"of residents'medical insurance in Shandong Province from 2015 to 2022.Methods:Spatial auto-correlation was used to analyze the spatial agglomeration and heterogeneity pattern;convergence analysis was used to analyze the inter-annual trends in the economic burden.Results:The"out-of-pocket ratio"increased year by year and the difference among cities was significant,the Moran's I value decreased year by year,and the geographical distribution pattern showed a random distribution pattern;the"government subsidy burden ratio"had little difference among cities,the global Moran's index value increased year by year,and the spatial agglomeration pattern was enhanced;both of them had σ convergence and absolute β convergence,showing a trend of balanced development.Conclusion:In order to promote provincial-level coordination,safeguard fund security and reduce the burden on residents,economic synergistic development strategies have been adopted to raise residents'incomes;emphasis has been placed on cutting back on income and expenditure,fine-tuning fund supervision;and reforming the financing mechanism,formulating fine-tuning financing standards and focusing on the increase in the cost of disease prevention and control have been adopted,so as to provide references for the improvement of the health insurance system and the promotion of the sustainable development of the health insurance cause.

Objective:To analyze the status quo and influencing factors of the equity,accessibility and sustainability of the development of medical insurance for urban and rural residents in 2021,and provide a reference for improving the management and service level of medical insurance.Methods:Firstly,the"evaluation index system of medical insurance for urban and rural residents"was constructed,and the total index of the development level of medical insurance and its three subsystem indexes of equity,accessibility and sustainability were calculated.Secondly,the Theil index was used to measure the level differences of the three major regions in the east,central and west,and the spatial auto-correlation was used to analyze the spatial agglomeration and heterogeneity distribution pattern of the total index.Finally,a geographic weighted regression model was constructed to analyze the main influencing factors.Results:There were provincial differences in the development level of medical insurance,which showed a decreasing trend from east to west in geography and a random distribution pattern in space.Policy factors,economic factors,population structure,medical resource allocation and education level had a significant impact on the development level of medical insurance.Conclusions:It is proposed to promote the fairness at multiple levels,enhance the accessibility in all directions and dynamically improve the sustainability,and further explore the policy suggestions to improve the management and service level and enhance the residents'sense of experience,sense of gain and sense of happiness.

To analyze the effect of diagnosis related group(DRG) reform in 2022 and its impact on patients in different departments, and create a policy environment that promotes the implementation of DRG.

Objective:To study the time evolution of financing burden and discuss the feasibility of provincial pooling by analyzing the panel data of"individual contribution burden ratio"and"government subsidy burden ratio"of residents'medical insurance in Shandong Province from 2015 to 2022.Methods:Spatial auto-correlation was used to analyze the spatial agglomeration and heterogeneity pattern;convergence analysis was used to analyze the inter-annual trends in the economic burden.Results:The"out-of-pocket ratio"increased year by year and the difference among cities was significant,the Moran's I value decreased year by year,and the geographical distribution pattern showed a random distribution pattern;the"government subsidy burden ratio"had little difference among cities,the global Moran's index value increased year by year,and the spatial agglomeration pattern was enhanced;both of them had σ convergence and absolute β convergence,showing a trend of balanced development.Conclusion:In order to promote provincial-level coordination,safeguard fund security and reduce the burden on residents,economic synergistic development strategies have been adopted to raise residents'incomes;emphasis has been placed on cutting back on income and expenditure,fine-tuning fund supervision;and reforming the financing mechanism,formulating fine-tuning financing standards and focusing on the increase in the cost of disease prevention and control have been adopted,so as to provide references for the improvement of the health insurance system and the promotion of the sustainable development of the health insurance cause.

Objective:To analyze the status quo and influencing factors of the equity,accessibility and sustainability of the development of medical insurance for urban and rural residents in 2021,and provide a reference for improving the management and service level of medical insurance.Methods:Firstly,the"evaluation index system of medical insurance for urban and rural residents"was constructed,and the total index of the development level of medical insurance and its three subsystem indexes of equity,accessibility and sustainability were calculated.Secondly,the Theil index was used to measure the level differences of the three major regions in the east,central and west,and the spatial auto-correlation was used to analyze the spatial agglomeration and heterogeneity distribution pattern of the total index.Finally,a geographic weighted regression model was constructed to analyze the main influencing factors.Results:There were provincial differences in the development level of medical insurance,which showed a decreasing trend from east to west in geography and a random distribution pattern in space.Policy factors,economic factors,population structure,medical resource allocation and education level had a significant impact on the development level of medical insurance.Conclusions:It is proposed to promote the fairness at multiple levels,enhance the accessibility in all directions and dynamically improve the sustainability,and further explore the policy suggestions to improve the management and service level and enhance the residents'sense of experience,sense of gain and sense of happiness.

Objective:To study the time evolution of financing burden and discuss the feasibility of provincial pooling by analyzing the panel data of"individual contribution burden ratio"and"government subsidy burden ratio"of residents'medical insurance in Shandong Province from 2015 to 2022.Methods:Spatial auto-correlation was used to analyze the spatial agglomeration and heterogeneity pattern;convergence analysis was used to analyze the inter-annual trends in the economic burden.Results:The"out-of-pocket ratio"increased year by year and the difference among cities was significant,the Moran's I value decreased year by year,and the geographical distribution pattern showed a random distribution pattern;the"government subsidy burden ratio"had little difference among cities,the global Moran's index value increased year by year,and the spatial agglomeration pattern was enhanced;both of them had σ convergence and absolute β convergence,showing a trend of balanced development.Conclusion:In order to promote provincial-level coordination,safeguard fund security and reduce the burden on residents,economic synergistic development strategies have been adopted to raise residents'incomes;emphasis has been placed on cutting back on income and expenditure,fine-tuning fund supervision;and reforming the financing mechanism,formulating fine-tuning financing standards and focusing on the increase in the cost of disease prevention and control have been adopted,so as to provide references for the improvement of the health insurance system and the promotion of the sustainable development of the health insurance cause.