OBJECTIVES

This study determined the prevalence of BBD among toilet-trained children attending a tertiary hospital’s pediatric outpatient clinic, and to evaluate the effectiveness of standard urotherapy among affected children.

METHODS

A prospective interventional study was conducted among 144 toilet-trained children aged 7 to 12 years seen at the University of Santo Tomas Hospital outpatient clinic from August 2025 to September 2025. Sociodemographic data were collected, and BBD was screened using the validated Filipino version of the Dysfunctional Voiding Symptom Scores (DVSS) questionnaire. Children with BBD underwent standard urotherapy, which included behavioral and lifestyle interventions such as timed voiding, adequate hydration, constipation management and proper voiding posture. DVSS assessments were repeated at two and four weeks.

RESULTS

The overall prevalence of BBD was 22.9% (33 of 144). BBD was significantly more prevalent among females (31.88%) than males (14.67%) (adjusted OR = 2.96, 95% CI: 1.28–6.86; p = 0.011). At baseline, children with BBD had significantly higher mean total DVSS scores (9.15 ± 3.64) compared to those without (2.01 ± 1.80, pCONCLUSION

Standard urotherapy proved effective in reducing symptom scores within two weeks and resulted in complete clinical resolution after four weeks among those who continued therapy. Routine screenings for BBD using DVSS and early initiation of standard urotherapy in pediatric outpatient settings are recommended to prevent complications and improve children’s urinary and bowel health.

Human ; Child: 6-12 Yrs Old ; World Health Organization ; Outpatient Clinics, Hospital ; Mass Screening ; Tertiary Care Centers ; Constipation ; Ambulatory Care Facilities

OBJECTIVE: MRI-Ultrasound fusion guided targeted biopsy has revolutionized the diagnosis of prostatecancer through accurate identification, localization and characterization of prostatic lesions utilizingthe prostate imaging reporting and data system (PI-RADS) scoring system by multiparametric MRI(MPMRI). The fusion prostate biopsy system on the other hand, enables accurate targeting and easyaccess of the tumor. The study objective is to determine the detection rate of clinically-significantprostate cancer using fusion biopsy, and to establish the correlation between PI-RADS score andGleason's score. PATIENTS AND METHODS: A retrospective cohort study was conducted to determine the correlation betweenPI-RADS score and the presence of prostate cancer using MRI-Ultrasound fusion guided transperinealprostate biopsy. This was carried out from June 2017 to July 2018 in a single institution. One hundredthirty five (135) men were included in this study. They presented with an elevated PSA, abnormalDRE or a previous negative prostate biopsy, but with a persistent rise in PSA. A total of 220 prostatelesions were identified. The following characteristics were measured: patient age; the size, location,the PI-RADS score of each lesion, the maximum PI-RADS score for select patients; and the Gleasonscore of discovered tumors. RESULTS: Two hundred twenty PI-RADS 3, 4 and 5 lesions were detected in 135 patients by MPMRI.131 of the 220 lesions were scored as PI-RADS 3, 61 as PI-RADS 4 and 28 as PI-RADS 5. Theselesions were biopsied using the MRI-Ultrasound fusion guided transperineal prostate biopsy system.Thirty-three out of the 131 PI-RADS 3 lesions (25.2%), 44 out of the 61 PI-RADS 4 lesions (72.1%)and 24 out of the 28 PI-RADS 5 lesions (85.7%) respectively were positive for malignancy. Overall,there were 101 (45.9%) lesions classified as PI-RADS 3 to 5 that were positive for prostate carcinoma.Seventy four (74) of the 135 patients (54.8%) were diagnosed with prostate adenocarcinoma. Nineteenout of 65 patients with a maximum score of PI-RADS 3 (29.2%), 33 of 44 with a maximum of PI-RADS 4 (75%) and 22 of 26 with a maximum of PI-RADS 5 (84.6%) harbored malignancy. In termsof location, 45 of the 101 (44.6%) malignancies were in the peripheral sector, 31 (30.7%) in theanterior sector, and 25 (24.8%) in the central sector of the prostate. The mean Gleason grade of PI-RADS 3, 4 and 5 lesions were 6.61, 7.73, and 7.38, respectively. Using Spearman correlation, the rhocoefficient was 0.3153 (p-value =.00013) which denotes a significant positive relationship betweenGleason and PI-RADS score. CONCLUSION This is the first comprehensive Philippine study on Multiparametric MRI-Ultrasoundfusion-guided transperineal prostate biopsy. Present data validate the superiority of MPMRI in theidentification, localization and characterization of prostate cancers. The authors also verified thepositive correlation between PI-RADS score and Gleason score. Finally, they demonstrated theaccuracy of the MRI- ultrasound fusion-guided transperineal prostate biopsy system in targetingprostate lesions.

OBJECTIVE: The purpose of this study was to compare voiding patterns of healthy infants and those with recurrent UTI aged 1-24 months.
METHODS: This was an analytical, cross sectional study of healthy infants and those with recurrent UTI, aged 1-24 months from March 1999 to March 2000 seen at University of Santo Tomas Hospital. The study included 100 subjects; Group I (50 subjects) healthy infants (neurologically intact with other anomalies ruled out by ultrasound and voiding cystourethrogram) Group 2 (50 subjects) are those with recurrent UTI. During the 24-hour period, all micturitions were recorded in terms of voiding frequency, volume and character of voiding. The observation was completed with three determination of residual urine volume using ultrasound by a single sonologist who did not know the diagnosis of each case. Voiding patterns in terms of mean voiding frequency, mean volume per voiding, mean functional bladder capacity and character of voiding were determined. Mean residual urine volume was also determined in milliliters. The two groups were compared using T test with a p value of 0.05 percent at 95 percent confidence interval.
RESULTS: The mean voiding frequency was 17.03 (SD +/- 7.5) in-group 1 and 13.5 (SD +/- 4.9) in-group 2 (p value of 0.009) The mean volume per voiding was 33.88 (SD +/- 15.2) on group 1 and 40.12 (SD +/- 37.4) in Group 2 (p value of 0.27). The mean bladder capacity was 44.02 (SD +/- 29.5) in group 1 and 66.48 (SD +/- 29.4) in group 2 (p value 0.00). In group 1 subjects, twenty eight percent showed interrupted voiding pattern compared to none in group 2 (p value 0.00). The mean residual urine volume for group 1 was 7.97 (SD +/- 7.5) and 6.06 (SD +/- 6.6) in group 2 (p value 0.183).
CONCLUSION: The voiding patterns of pediatric patients with recurrent UTI were significantly characterized by increased frequency, decreased functional bladder capacity, and interrupted voiding. Mean volume per voiding was also decreased in those with recurrent UTI but not to a significant degree. Determination of residual urine in those with recurrent UTI was not significantly different from healthy infants.

Human ; Male ; Female ; Infant ; Urination ; Urinary Bladder ; Cross-sectional Studies ; Confidence Intervals ; Urinary Tract Infections ; Urinary Retention ; Cystography ; Polyuria