Background: According to the World Health Organization (2021), low back pain (LBP) affected approximately 619 million people worldwide in 2020, and the number of cases is projected to increase to 843 million by 2050, mainly due to population growth and aging. A study conducted in the Neurosurgery Department of the National Trauma and Orthopedic Research Center reported that over the past five years, the number of surgeries performed due to spinal disorders, particularly intervertebral disc herniation causing compression of the spinal cord and nerve roots has increased four to fivefold. Furthermore, this condition accounts for the majority of patients seeking treatment abroad. According to the 2023 statistical report of the State Central Hospital, a total of 477 surgeries were performed in the Neurosurgery Department. However, there are relatively few studies that have compared and evaluated pain levels before and after spinal surgery among patients. Therefore, this study was conducted to address this research gap. Aim: To compare and examine the intensity of back pain before and after surgery among patients who have undergone spinal surgery. Materials and Methods: This study employed a cross-sectional design using a quantitative research approach. A total of 123 patients who underwent spinal surgery at the Neurological Clinical Center of the State Central Hospital were randomly selected and included in the study. Pain intensity in patients undergoing spinal surgery was assessed using the Visual Analogue Scale (VAS) developed by Hayes and Patterson et al. A linear pain intensity assessment method was applied, and the study utilized a questionnaire consisting of 13 sociodemographic items. Result: All participants (100%) reported pain prior to surgery. Assessment of pain intensity showed that 1.6% (n=2) had mild pain, 52.8% (n=65) had moderate pain, and 45.5% (n=56) had severe pain. On the third postoperative day, pain assessment indicated improvement, with 51.2% (n=63) reporting no pain and 48.8% (n=60) reporting mild pain. The mean pain intensity score decreased from 4.63±0.53 before surgery to 1.48±0.50 after surgery (p = 0.009). Analysis of factors affecting postoperative pain revealed a significant association with the type of surgical procedure performed (p<0.03). Conclusion Comparison of pain intensity before surgery and on the third postoperative day among patients who underwent spinal surgery demonstrated significant improvement. Preoperative pain intensity varied according to the surgical indication, while postoperative pain was significantly associated with the type of surgical procedure and body mass index (BMI).

Background : Activities of Daily Living (ADL) refer to the essential self-care tasks necessary for independent living. A 2021 study conducted in France by researchers Axelle Kostenobel and Wierle Knoop found that the loss of independent functioning is a syndrome of physiological decline, with 60% of post-surgical patients experiencing a reduction in their independence. In Mongolia, there is limited research on the ability of post-surgical patients to perform daily activities independently. Therefore, this study was conducted to address this gap. Aim: The objective of this study is to assess the level of independence among patients admitted to the Surgical Department of the Mongolian-Japanese Hospital and to analyze the interrelationships between different functional abilities. Materials and Methods: This study was conducted as a cross-sectional quantitative study involving 185 patients who underwent surgery at the Surgical Department of the Mongolian-Japanese Hospital, affiliated with the Mongolian National University of Medical Sciences. The patients’ independence levels were evaluated postoperatively using the standard six-question ADL assessment questionnaire developed by Katz et al. (1963). The collected data were analyzed using SPSS 25.0, with normality distributions assessed. Since the data did not follow a normal distribution, Spearman’s rank-order correlation coefficient was used to determine the strength of associations between variables. Results: Among the study participants, 50.8% (n=94) were male, and 49.2% (n=91) were female. The average age was 47.9±14.56 years, and the mean hospital stay was 2.7±1.6 days. The assessment of independence levels revealed that: • 11.9% (n=22) were completely dependent, • 21.1% (n=39) had impaired independence, and • 67% (n=124) maintained normal or good independence. The mean hospital stay for patients with normal or good independence was 2.51±1.42 days, while it was 2.79±1.73 days for those with impaired independence and 3.6±2.03 days for fully dependent patients. There was a weak positive correlation between independence level and length of hospital stay (r=0.159, p=0.03). Strong direct correlations were observed between: • Eating ability and dressing ability (r=0.671, p=0.001), bathing ability (r=0.568, p=0.001), mobility (r=0.571, p=0.001), toileting ability (r=0.588, p=0.001), and continence control (r=0.609, p=0.001). • Dressing ability and bathing ability (r=0.766, p=0.001), mobility (r=0.723, p=0.001), toileting ability (r=0.788, p=0.001), and continence control (r=0.736, p=0.001). • Bathing ability and mobility (r=0.789, p=0.001), toileting ability (r=0.715, p=0.001), and continence control (r=0.644, p=0.001). • Mobility and toileting ability (r=0.822, p=0.001) and continence control (r=0.770, p=0.001). • Toileting ability and continence control (r=0.909, p=0.001). Conclusion One-third of the patients admitted to the surgical department experienced a decline in independence or complete dependence postoperatively, which was weakly correlated with a longer hospital stay. The various functional abilities that determine independence were strongly interrelated.

Background: The craniofacial region is one of the most frequently injured parts of the human body, with mandibular fractures being the most common type of facial skeletal injury. The leading causes of mandibular fractures include traffic accidents, falls, interpersonal violence, and sports-related injuries. In Mongolia, mandibular fractures are prevalent, with a higher incidence among males. However, to date, no national-level analysis of mandibular fractures has been conducted. This study aims to comprehensively examine mandibular fractures in Mongolia by identifying demographic factors and causes of injury. Aim: To determine the incidence and causes of mandibular fractures recorded in Mongolia over the past ten years. Materials and Methods: This study collected data on mandibular fractures recorded in the Health Development Center of Mongolia between 2014 and 2023. Cases were identified using the International Classification of Diseases (ICD-10) code S02.6. Information on patient age, gender, and hospital diagnosis was collected, along with the cause of injury, classified according to ICD-10 codes. Patient age was categorized based on the classification system of the National Statistics Office. Statistical analysis was performed using SPSS 26.00 software, employing the chi-square test for data analysis. Results: During the study period, a total of 2,872 patients were diagnosed with mandibular fractures, with the highest incidence occurring in the 20-40 age group. The average patient age was 31.1±12 years. Males were 5.6 times more likely to sustain mandibular fractures compared to females. The primary causes of injury were interpersonal violence (42%), mechanical trauma (17%), falls (16%), and traffic accidents (15%). Conclusion Between 2014 and 2023, 2,872 cases of mandibular fractures were recorded in Mongolia, with the majority occurring in individuals aged 20-40 years. The leading causes of mandibular fractures were interpersonal violence, mechanical trauma, falls, and traffic accidents. Specialized trauma care services were accessed differently in urban and rural areas.

The microbiologist, who aged 44 man has work with glander DNA extraction between January and March at 2022, was developed sumptoms with fever, headache, muscle pain, weakness, cut throat, cough at 4 March, 2022. On March 7, he had tested Covid-19 and the result was negative. He was given 1gr tefazoline by eight-time interval for two days. Despite completing the therapy, episodes of fever and headache increased. A medical evaluation, which included MRI test was no disorder was developed. On March 12, painful with leg and developed muscle pain. He continued to difficulty to walk and cough, fever and weakness. On March 13, he has admitted hospital with diagnoses pneumonia.
He had continued sign with pneumonia in both lung, fever, infiltration with right leg, cough, headache, and glandule node in hospital. By PCR test, glander DNA was detected in sputum in National Center for Zoonotic Diseases laboratory. He recovered 20 days in hospital.
He has 12 days incubation period and infection route was by worked with glander strain and it was pneumonia form with laboratory-acquired human glanders.
Human glander case is rare in Mongolia. Three human glander cases had registered in 1966, 1972, 1977 among prison’s horse herder in Mongolia.

Purpose: Researchers suggest that the prevalence of infertility varies between developing and developed countries, with differences in infertility care, socioeconomic status, lifestyle, and reproductive disorders such as pelvic inflammatory disease and sexually transmitted infections being the main risk factors. The research project aims is to define risk factors for female fertility in the Mongolian population. Methods: This study was conducted between 2016-2018 using a cross-sectional survey of analytical research. Participants were randomly selected from Ulaanbaatar and the Central, Western, Eastern, and Khangai provinces according to Mongolia’s regional geographic model. The contents of a questionnaire were comprised of 5 units with 95 questions including socio-economic, geographical, lifestyle, health education, reproductive health indicators, sexual behavior. General physical characteristics were measured according to the standard. Results: The prevalence of the female fertility rate in the Mongolian population is 7.4%. Female participants were classified into 2 groups, namely infertile and fertile, and we developed a case-control study. Among the socio-economic factors influencing infertility, primary education aOR: 1.6 (95% CI 0.98-2.66), monthly household income lower than the average aOR: 1.1 (95% CI 0.77- 1.66), living in rural areas OR: 2.3 ( 95% CI 1.46-3.68) were crucial risk factors. As for reproductive and general health indicators, STIs aOR: 1.8 (95% CI 0.98-3.50), especially gonorrhea OR: 2.8 (95% CI 1.14-6.91), and thyroid disorders OR: 1.7 (95% CI 1.03). -2.97), grade 3 obesity OR: 3.8 (95% CI 1.05-13.95) are estimated risk factors for infertility. Conclusions Of all potential socio-economic factors, residence status, education and financial situation are significant for female infertility meanwhile reproductive health indicators include sexually transmitted infections, thyroid disease, and obesity.

Objective: This study examines the job satisfaction of Mongolian hospital nurses by comparing their status and workload of Mongolian nurses with Japanese nurses’ one.Settings and participants/Methods: Survey data were collected from randomly selected 200 nurses (100 were Mongolians and the other 100 were Japanese) who agreed to participate in the survey. Data were collected through a self-administered survey questionnaire. Survey items were age, the duration of work experience, work position, health condition, accumulated fatigue, stress level, and whether having family members who need child care or nursing care. Collected data were analyzed by t-test and Wilcoxon Rank Sum test.Results: The average age of Mongolian nurses was significantly lower than that of Japanese nurses. Consequently, the average work experience of Mongolian nurses was less than that of Japanese nurses. More Japanese than Mongolian nurses had family members in need of care. Job satisfaction and status were significantly higher among Japanese than Mongolian nurses. However, Japanese nurses have family members who need child care or nursing care at a higher rate than Mongolian nurses. Job satisfaction of Japanese nurses about their work and job status was significantly higher than Mongolian nurses’ one. However, the opposite result was found in the job satisfaction about their workload. The influence of the relationships among nurses on the job satisfaction was significantly greater in Mongolian nurses than in Japanese nurses. Job satisfaction of Japanese nurses about their salaries was significantly higher than Mongolian nurses’ one.Conclusion: In order to raise nurses’ job satisfaction in Mongolia, it is necessary to raise their “occupational status” and salary of nurses.

Introduction: Endothelial progenitor cells (EPC) have a role in the maintenance and promotion of vascular repair and are negatively correlated with coronary atherosclerosis. Goal: To culture of EPC-CFUs during coronary atherosclerosis, evaluate endothelial nitric oxide synthetase (eNOS) enzyme levels in the culture. Materials and Methods: The 10 ml blood was drawn from the peripheral vein of 12 man patients that stable angina 4, acute myocardial infarction (AMI) 4 and healthy people 4. Peripheral blood mononuclear cells were isolated by Ficoll density-gradient centrifugation and EPC-CFUs was assayed after two platings and a 6 day culture on fibronectin coated, 72 well plates, as described. eNOS enzyme titers were determined by ELISA according to the protocol in the cells culture. Results: The people were 52±2.12 years. The number of EPC-CFUs increases with accordance of patients with stable angina, AMI, healthy people with the statistical significance (F=17.3, p<0.001): stable angina (2.6±0.47 colony/well), AMI (6.7±0.81 colony/well), healthy people (10.5±1.34 colony/well). Furthermore, ANOVA test of eNOS enzyme levels in patients with stable angina (5.2±0.61 pg/ml), AMI (8.7±1.49 pg/ml) and healthy people (13.7±2.48 pg/ml). The significant difference (F=6.2, p=0.003) was observed among the three groups. The number of EPC-CFUs had direct significantly correlation (r=0.621, p<0.001) with the eNOS enzyme levels of this culture. Conclusion: Number of EPC-CFUs and eNOS enzyme levels decrease at patient with stable angina, indicate more than endothelial dysfunction. Ethical approval The ethics committee of Mongolian National University of Medical Sciences (ID: 6/3/201506, approved on Jan 01, 2015)

BACKGROUND: According to the World Health Organization (WHO), 10-15% of couples of reproductive age have infertility. According to researcher D. Sukhe (1999), hormonal infertility in the reproductive age of women was 33.6%, which was a large part of the cause of infertility. In recent years, the number of cases of endocrine disorders, including malignancy and sexually transmitted infections, has been increasing year by year. According to WHO reports, thyroid disorders have a prevalence of 49.3% for active reproductive age (30-50). According to the report of the Health Development Center in 2016, since the thyroid disorders are the second most common disease in endocrine gland disease, our study found that the infertility in reproductive age of women can be substantial due to the loss of thyroid gland. METHODS: The study was carried out by the couple of 20-45 year-olds and modeled as an analytical study model. The questionnaire was used for the couple’s interviews and some of the measurement of body and serum use of TOSOH Corporation AIA-360, Tokyo, Japan. On the serum, anti-TPO and аnti-TG carbohydrates are identified by the Cobas e-411 analyzer under the manufacturer’s accompanying protocol. RESULTS: 76.7% of women were diagnosed with infertility euthyroid, 0.7% hyperthyroidism, 22.6% hypothyroidism (3.8% with overt hypothyroidism and 18.8% subclinical hypothyroidism). Prevalence of TAI, in 6.7% isolated positive anti-Tg were found, and 14.3% had isolated positive TPO, In 3.7% of cases, both types of autoantibodies were present. We analysed binary logistic regression for anti-TPO and anti-TG autoantibody in the positive and negative group in past obstetrics history, evidence of positive of anti-TPO and anti-Tg was increased risk of miscarriage 2.2 times (OR = 2.2, p <0.01). CONCLUSIONS: Women with disorders in our study have high percentage of subclinical hypothyroidism and have higher rate of thyroid autobodies in serum which may be a problem for women with infertility and pregnancy complications due to the loss of thyroid gland. There is a need to develop a principle of recovery and treatment.

Objectives: This study aims to survey the prevalence and risk factors of hypertension (HTN) among nurses. Methods: Data was collected from 528 nurses of 23 hospitals in Ulaanbaatar (UB) and local hospitals in other regions. We randomly selected day-shift only nurses (264) and shift nurses (264), collected blood samples, administered a health survey questionnaire, and processed data with SPSS 19.0 statistic software. Results: Overall, 8% of participants who work for shift and 7.2% of day working nurses are smokers (p<0.0001). 3.2% of shift working nurses and 3.8% day working nurses use overuse alcohol (p<0.0001). The day working nurses and the shift working nurses and compared their BMI to measured normal (42.1% and 36.4%) overweight (39.7% and 43.9%), obesity (18.2% and 19.7%) (p<0.02), central obesity normal (39.4% and 34.5%), and central obesity≥ 80 (60.6% and 65.5%), body fat percentages are normal (29.2% and 16.1%) and increase (70.8% and 73.9%), visceral obesity are normal (65.9% and 63.3%) and increase (34.1% and 36.7%). Nurses (day-work and shift-work) who have arterial HTN are detected by normal (72.3% and 59.1%), prodromal period (14.4% and 16.7%), 1st stage (12.1% and 19.7%), 2nd stage (1.2% and 4.5%) (p<0.002). Working time of nurses detected that shift working nurses’ arterial hypertension amount is higher than day time working nurses. Conclusion: 24.2% of shift working nurses have HTN is showed that higher than day time working nurses. Hypertension is directly related to overweight, obesity, visceral obesity and high blood glucose level. (p<0.0001).

BackgroundThe preparations of multi-component have been the subject of chemical study for a long time. Therefore, when compounding the preparations of multi-component in traditional medicine, their taste is cautiously relied on, as the power of the one medicine should not be subdued with the power of another. Additionally the properties of the components and their regulating effects on the body systems are also considered. Our research group has been carrying out tests for raw materials,which are contained in multi-component preparations. However, it is a necessity to conduct phytochemical study on multi-component preparations in order to isolate pure biological active compounds and to identify their structure as well as to quantify its amount by modern techniques of analysis.GoalThe aim of the present study was to isolate pure biological active substances from Mongolian traditional medicine Garidi-5 and to elucidate their structures, which was used in Mongolian traditional medicine for the treatment of inflammation and as a pain relieving remedy.Objectives:1. To isolate pure substances from Garidi-5 and carry out tests to identify and determine their structure2. To quantify the amount of biological active substances.Materials and MethodsMongolian traditional medicine Garidi-5 has been selected as a biological natural product for the study. Garidi-5 is a traditional Mongolian medicine consisting of 5 medicinal herbs, namely Terminalia chebula Retz., Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus and manufactured in the Drug factory of Traditional Medical Science Technology and Production Corporation of Mongolia. In this research, in order to determine the total content of phenolic compound was used the Folin–Ciocalteu method, which based on performing dark blue color complex compound. Isolated substance identification was determined by the TLC, UV and IR spectrophotometric methods. Inaddition it was checked melting point of the isolated substance. Determination of Gallic acid30g Garidi-5 was macerated in 60ml 80% methanol at room temperature for 24 h. After extraction, the extract was concentrated and vacuum evaporated. Different solvents from hexane, chloroform, ethyl acetate and n-butanol were used for theexperiment. All the extracts collected, evaporated and chromatographed on Silica gel column. Future purification of active fractions on Silica gel with methanol yielded the compound G1 which was further characterized as Gallic acid. Total phenolic content was determined spectrophotometrically according to the Folin–Ciocalteu’s method with slight modification. Gallic acid was used as a standard phenolic compound. Briefly, 1 ml of extract solution contains 1 mg extracts, in a volumetric flask diluted with distilled water (46 ml). One ml of Folin-Ciocalteu reagent was added and the content of the flask mixed thoroughly. After 3 min, 3 ml of Na2CO3 (2%) was added and then the mixture was allowed to stand for 2 h with intermittent shaking. The absorbance was measured at 760 nm in a spectrophotometer. All measurements were performed in triplicate.ResultsIn this research, TLC method on silica gel plates was used in order to identify the biological active pure substances from Garidi-5. Preliminary TLC experiments indicated the presence of Gallic acid in Garidi-5, which was isolated by column chromatography by comparing with reference standard substance (Gallic acid). Gallic acid was determined in the solvent system benzole-ethyl acetateformic acid- acetone (5:5:2:0.5) in isolated substance (G1). It showed blue color, Rf =0.65, on TLC plate. [1] For the characterization of two samples it was carried out IR analysis for each. In the IR spectra of G1 and standard substance can be recognized by the following absorption frequency regions: 700-900 cm-1 for Car-H; 1000-1300 cm-1 for vibration of bonds in various oxygen containing groups, 1350-1470 cm-1 for vibrations of –CH, -CH2 and –CH3 groups; 1500-1630 cm-1 for skeletal vibrations of aromatic rings, >C=O bonds; 2800-2950 cm-1 for stretching vibrations of –CH, -CH2 and -CH3 groups in saturated aliphatic structures; and 3030-3350 cm-1 for stretching associated vibrations of -OH groups in aromatic rings and aliphatic structures. As a result it was revealed that both IR spectra of G1 and standard substances were similar. [3]Further for the characterization of two samples it was carried out UV analysis of each. In the UV spectra of G1 and standard substance can be recognized by the following absorption frequency regions: 260-280nm for benzole groups; 200-225nm for carbonic acids; 400-770nm >C=O bonds, which reveal the presence of Gallic acid. In addition, melting point of isolated substance G1 was analyzed and detected at 2410C, which was similar to the standard substance’s melting point. [4]Moreover, Mongolian traditional medicine Garidi-5 contains 24% of the biological active substance (total phenolic compounds). [2]Conclusions:As a result of current study on Mongolian medicine Garidi-5, it was isolated one essential substance from ethyl acetate fraction. The phytochemical analysis reveals the presence of Gallic acid in Garidi- 5, which was determined by thin layer chromatography, UV and IR spectrophotometric methods. Mongolian traditional medicine Garidi-5 contains 24% of the biological active substance. Thus, the isolation of Gallic acid from multi-component preparations and identification of its structure was first phytochemical study conducted in our laboratory.