Hepatocellular carcinoma(HCC)is one of the most common malignant tumors worldwide.Transarterial chemoembolization(TACE)has been an important method for the treatment of advanced HCC.At present,drug-eluting beads chemoembolization(DEB-TACE)has been widely employed in the treatment of HCC,and different brands and different sized drug-eluting beads have been developed and used in DEB-TACE.In clinical practice,the particle size of drug-eluting beads is selected according to the HCC size and its blood supply,generally,＜300 μm drug-eluting beads are recommended.At present,100-300 μm drug-eluting beads have been frequently used.In recent years,smaller-sized drug-eluting beads have been employed in TACE.This article reviews the clinical effectiveness and safety of small-sized drug-eluting beads(＜150 μm)in DEB-TACE for HCC,so as to provide reference for clinical treatment.