Objective To investigate the clinical efficacy of low molecular weight heparin combined with ginkgo dipyridamole on the patients with acute cardiogenic cerebral embolism .Methods Eighty cases of cardiogenic cerebral embolism admitted into the Department of Neurology of the hospital from July 2015 to July 2016 were recruited as research subjects .With the knowledge of the pa-tients and consent of their dependents , the patients were equally divided into 2 groups: the observation group and the control group , each consisting of 40 patients.After admission into the hospital , the patients of the 2 groups were given the same basic treatment and the treatment for complication prevention .The patients of the observation group received treatment of low molecular weight heparin com -bined with ginkgo dipyridamole for the treatment of acute cardiogenic cerebral embolism , while the patients of the control group were just given low molecular weight heparin .Recovery of neurological insufficiency and clinical efficacy were compared between the 2 groups both before and after treatment , and at the same time, adverse reactions were also observed and compared between the 2 groups.Results After treatment, the neurological function scores of the observation group were significantly higher than those of the control group , and statistical significance could be seen when comparisons were made between them (P<0.05).Total therapeutic efficacy of the observa-tion group was 97.5%, which was significantly higher than that of the control group (67.5%), also with statistical significance (P<0.05).There was no statistical significance in adverse reactions , when comparisons were made between the 2 groups(P>0.05). Conclusion Low molecular weight heparin combined with ginkgo dipyridamole in the treatment of acute cardiogenic cerebral embolism could produce much better effect than single application of low molecular weight heparin .

ObjectiveTo explore the relationship among dream threat level,life events and childhood trauma in obsessive-compulsive patients.Methods 59 obsessive-compulsive patients and 57 healthy controls were tested with Dream Threat Questionnaire (DTQ),Childhood Trauma Questionnaire ( CTQ ) and Life Events Scale (LES).The dream threat level were compared between the two groups,and correlation and regression analysis were used to research the relationship of the variables for patients’ data.ResultsCompared with the healthy controls,patients had significantly higher DTQ score ( 1.40 ± 2.23 vs 3.31 ± 3.04,P ＜ 0.01 ),CTQ total score (34.21 ± 8.47 vs 43.02 ± 10.78,P ＜ 0.01 ),LES total score ( 16.88 ± 16.42 vs 45.39 ± 46.01,P ＜ 0.01 ) and its negtive life events subscore ( 14.14 ± 14.61 vs 39.56 ± 42.94,P ＜ 0.01 ).Correlation analysis showed that dream threat level,negative life events and childhood trauma were significantly positively correlated each other( r =0.326 ～0.402,P ＜ 0.05 ～0.01 ).Regression analysis indicated that childhood trauma directly predicted dream threat level (β =0.104,P ＜ 0.05 ) and completely mediated the relationship between negative life events and dream threat level.ConclusionObsessive-compulsive patients have higher dream threat level,more childhood trauma experience and life events.Childhood trauma experience is a significant factor influencing dream threat level,and as a complete mediation by which life events influence dream threat level.

Objective To evaluate the antiretroviral therapy(ART),analyze the prevalence of resistance in rural areas,Henan,and explore the presence of minor resistant variants in pre-ART.Methods One hundred and forty-nine AIDS patients initiating ART were recruited and investigated at intervals of 6 months. Method of In-house developed by our laboratory for genotypjc resistance test was to analyze the occurrence of resistance among the failure of ART,and the allele-specific real.time PCR(ASPCR)was used to detect the minor resistant variants at the baseline samples once the resistance occurred.Results Vimlload significantly decreased among the patients who received ART(t=275,P=0.0001),but the absolute counts of CD4+T lymphocytes had no significant change(t=1.765 168,P=0.0852).Rate of resistance among the patients of treatment failure was 4.88%.The result of ASPCR in the survey of baseline showed that the minor resistant variants of M184V were detected in 7 patients and mutation K103N presented in 5 patients.Conclusion The primary drug-resistant straias in the untreated patients were found in Henan,and they might develop the dominant resistance strains and bring about the failure of ART.