Objective:To construct an evidence-based cluster intervention program for the prevention of enteral nutrition complicated with diarrhea in patients with craniocerebral injury, and to verify its effect, in order to provide the best evidence for reducing the incidence of enteral nutrition complicated with diarrhea in patients with craniocerebral injury and improve the quality of nursing.Methods:By the method of non-synchronous controlled trials, the patients with craniocerebral injury treated by enteral nutrition in the Department of Neurosurgery, Lu'an Hospital of Traditional Chinese Medicine were selected as the research objects by convenient sampling method. Fify-two cases of routine intervention from January 2021 to March 2022 were divided into control group, and 51 cases of evidence-based cluster prevention intervention from April 2022 to February 2024 were divided into observation group. After 14 days of intervention, diarrhea [incidence of diarrhea and defecation traits (watery stool, loose stool), frequency of defecation, time of diarrhea and duration of diarrhea], other complications, nutritional status (serum total protein, serum albumin and hemoglobin), and nursing satisfactory degree were compared between the two groups.Results:Both groups of patients completed the study. There were 33 males and 19 females in the control group, aged (53.96 ± 17.44) years old, and 37 males and 14 females in the observation group, aged (60.05 ± 18.61) years old. The incidence of diarrhea and watery stools in the observation group was 11.76% (6/51) and 7.84% (4/51), respectively, which was lower than the 28.85% (15/52) and 23.08% (12/52) in the control group, and the differences were statistically significant ( χ2=4.63, 4.55, both P<0.05). The frequency of defecation in the observation group was (6.71 ± 1.64) times, which was lower than that in the control group (9.34 ± 2.10) times, and the difference was statistically significant ( t=7.08, P<0.05). The occurrence time of diarrhea in the observation group was (1.97 ± 0.54) d, which was later than that in the control group (1.59 ± 0.42) d, and the difference was statistically significant ( t=3.99, P<0.05). The duration of diarrhea in the observation group was (3.11 ± 0.86) d, which was shorter than that in the control group (5.12 ± 1.74) d, and the difference was statistically significant ( t=7.41, P<0.05). The incidence of other complications in the observation group was 9.80% (5/51), which was lower than the 25.00% (13/52) in the control group, and the difference was statistically significant ( χ2=4.12, P<0.05). After 14 days of intervention, the serum total protein, serum albumin, and hemoglobin levels in the observation group were (60.58 ± 6.37), (41.29 ± 8.24), (120.81 ± 11.72) g/L, respectively, which were higher than those in the control group (57.86 ± 6.15), (37.56 ± 7.64), (111.26 ± 11.25) g/L, and the differences were statistically significant ( t=2.21, 2.38, 4.22, all P<0.05). The patients′ overall satisfaction with nursing care in the observation group was 96.08% (49/51), which was higher than the control group′s 80.77% (42/52), and the difference was statistically significant ( χ2=5.86, P<0.05). Conclusions:The implementation of evidence-based cluster prevention intervention for enteral nutrition patients with craniocerebral injury can reduce the incidence of diarrhea in patients, which is conducive to the recovery of nutritional status, improve nursing satisfaction.

Objective:To construct an evidence-based cluster intervention program for the prevention of enteral nutrition complicated with diarrhea in patients with craniocerebral injury, and to verify its effect, in order to provide the best evidence for reducing the incidence of enteral nutrition complicated with diarrhea in patients with craniocerebral injury and improve the quality of nursing.Methods:By the method of non-synchronous controlled trials, the patients with craniocerebral injury treated by enteral nutrition in the Department of Neurosurgery, Lu'an Hospital of Traditional Chinese Medicine were selected as the research objects by convenient sampling method. Fify-two cases of routine intervention from January 2021 to March 2022 were divided into control group, and 51 cases of evidence-based cluster prevention intervention from April 2022 to February 2024 were divided into observation group. After 14 days of intervention, diarrhea [incidence of diarrhea and defecation traits (watery stool, loose stool), frequency of defecation, time of diarrhea and duration of diarrhea], other complications, nutritional status (serum total protein, serum albumin and hemoglobin), and nursing satisfactory degree were compared between the two groups.Results:Both groups of patients completed the study. There were 33 males and 19 females in the control group, aged (53.96 ± 17.44) years old, and 37 males and 14 females in the observation group, aged (60.05 ± 18.61) years old. The incidence of diarrhea and watery stools in the observation group was 11.76% (6/51) and 7.84% (4/51), respectively, which was lower than the 28.85% (15/52) and 23.08% (12/52) in the control group, and the differences were statistically significant ( χ2=4.63, 4.55, both P<0.05). The frequency of defecation in the observation group was (6.71 ± 1.64) times, which was lower than that in the control group (9.34 ± 2.10) times, and the difference was statistically significant ( t=7.08, P<0.05). The occurrence time of diarrhea in the observation group was (1.97 ± 0.54) d, which was later than that in the control group (1.59 ± 0.42) d, and the difference was statistically significant ( t=3.99, P<0.05). The duration of diarrhea in the observation group was (3.11 ± 0.86) d, which was shorter than that in the control group (5.12 ± 1.74) d, and the difference was statistically significant ( t=7.41, P<0.05). The incidence of other complications in the observation group was 9.80% (5/51), which was lower than the 25.00% (13/52) in the control group, and the difference was statistically significant ( χ2=4.12, P<0.05). After 14 days of intervention, the serum total protein, serum albumin, and hemoglobin levels in the observation group were (60.58 ± 6.37), (41.29 ± 8.24), (120.81 ± 11.72) g/L, respectively, which were higher than those in the control group (57.86 ± 6.15), (37.56 ± 7.64), (111.26 ± 11.25) g/L, and the differences were statistically significant ( t=2.21, 2.38, 4.22, all P<0.05). The patients′ overall satisfaction with nursing care in the observation group was 96.08% (49/51), which was higher than the control group′s 80.77% (42/52), and the difference was statistically significant ( χ2=5.86, P<0.05). Conclusions:The implementation of evidence-based cluster prevention intervention for enteral nutrition patients with craniocerebral injury can reduce the incidence of diarrhea in patients, which is conducive to the recovery of nutritional status, improve nursing satisfaction.

Objective To observe the effects of Buxu Huayu P rescription(BHP)on myeloid hematopoiesis in tumor -b ear-ing mice after combined chemotherap y.Methods Tumor -bearing mouse models were established by implanting P388tu-mor strain and the arrest of myeloid h ematopoiesis in the models was induced by intraperitoneal injection of c yclophos-phamide(CTX)and cytarabine(Ara -c ).The mice were allocated to 3groups:the normal control group,the model group and BHP group.Peripheral bloo d cell count,bone marrow karyocytes(BMK)count,colony count of progenitors o f granulocytes /monocytes(CCP -GM)and the proliferation of bone marrow cells(BMC)were examined.Results The combination of CTX and Ara -c could decrease plasma hemoglobin(Hb )content,the number of white blood cells(WBC),BMK and CCP -GM and the proliferatio n of BMC in model mice(P