OBJECTIVE To establish an integrated central pharmacy management model combining the inpatient pharmacy and the pharmacy intravenous admixture service （PIVAS）， and to evaluate its effectiveness and economic value in terms of operational cost composition， dispensing output， and dispensing efficiency.METHODS Through spatial integration， flexible staff scheduling， the application of intelligent equipment， and a dual prescription review system， the inpatient pharmacy and PIVAS were integrated， and an integrated management model was implemented. Operational data from the Fourth Affiliated Hospital of Soochow University （hereinafter referred to as “our hospital”） in 2023 were selected for analysis， with national median data and data from another hospital in the same region that still implemented a separate management model for the inpatient pharmacy and PIVAS serving as controls. The activity-based costing method was used to calculate operating costs. Dispensing output， dispensing efficiency， and unit activity cost were compared among the three. Cost-benefit analysis was further conducted by calculating the net benefit （NB） and the incremental cost-effectiveness ratio （ICER） for economic evaluation.RESULTS Under the integrated central management model， the total operational cost of our hospital’s central pharmacy was 3.968 3 million yuan， representing an 11.80% reduction compared with the external hospital’s pharmacy （4.499 0 million yuan）， with consumable costs and labor costs decreasing by 38.73% and 10.99%， respectively. The total prescription dispensing volume （3.613 4 million orders） was 43.58% higher than that of the external hospital’s pharmacy （2.516 7 million orders）. The daily dispensing volume per capita reached 471.41 medication orders， 3.5 times that of the external hospital’s pharmacy （135.20 medication orders）. The unit activity cost was 1.10 yuan， showing a 38.55% decrease relative to the external hospital’s pharmacy （1.79 yuan）. The NB was 755 200 yuan， and the ICER was －2.36. In terms of PIVAS operations， the daily dispensing volume per capita for general infusions （including antibacterial drugs） in our hospital was 50.83 sets， higher than the national PIVAS median （49.11 sets） and the external hospital pharmacy （36.14 sets）； the daily dispensing volume per capita for hazardous drugs was 0.86 sets， higher than the national median （0.70 sets） and the external hospital pharmacy （0.16 sets）.CONCLUSIONS The integrated central pharmacy management model established by our hospital achieved reduced operational costs and enhanced staff efficiency despite growing service volumes. Integrating the functions of both the inpatient pharmacy and the PIVAS， this model outperformed national medians and peer hospitals in dispensing output， dispensing efficiency， unit activity cost control， and economic evaluation， and surpassed the national median specifically in PIVAS dispensing efficiency.

Objective To evaluate the relationship between perioperative myocardial injury(PMI)and serum N/OFQ levels in elderly patients with coronary heart disease.Methods Totally 120 elderly patients who underwent hip fracture surgery under general anesthesia from January 2022 to May 2023 were included,including 60 patients with coronary heart disease(CHD group)and 60 patients without coronary heart disease(control group).The venous blood of patients was collected 10 minutes before anesthesia induction(T0),12 hours after surgery(T1)and 24 hours after surgery(T2)to detect the content of N/OFQ and high-sensitivity myocardial troponin I(hs-cTnI)in serum.Record perioperative adverse cardiovascular events(PACE)and the use of vasoactive drugs during surgery.Results Compared with the control group,the N/OFQ and hs cTnI levels at T0 and T1 in the CHD group were significantly increased(P<0.05).There was a positive correlation between N/OFQ and hs-cTnI levels at T1 and T2 in CHD and control group(P<0.05).The use of PACE and intraoperative vasoactive drugs in the CHD group was higher than that in the control group(P<0.05).Conclusion There is a correlation between the increased N/OFQ content and PMI in elderly patients with coronary heart disease after surgery,which may become an early predictive indicator of PMI.

Objective:To evaluate the efficacy and safety of oral anisodine hydrobromide tablets in the treatment of nonarteritic anterior ischemic optic neuropathy (NAION).Methods:A multicenter nonrandomized controlled trial was conducted.A total of 282 acute NAION patients (282 eyes) were recruited from 16 hospitals in China from July 2020 to May 2021.Patients were divided into two groups according to treatment methods, which were control group (124 cases, 124 eyes) receiving regular treatment including citicoline sodium plus Ginkgo biloba leaf liquid extract or Ginkgo biloba leaf extract tablets plus mecobalamin, and experimental group (158 cases, 158 eyes) receiving treatment in control group plus oral anisodine hydrobromide tablets 1 mg, twice daily for 2 to 3 months.Best corrected visual acuity (BCVA), visual field index (VFI), peripapillary retinal nerve fiber layer (pRNFL) and radial peripapillary capillary vessel density (RPC) were assessed at 1, 2, 3, and 6 months after enrollment using the standard decimal visual acuity chart, 750i Humphery visual field analyzer, Cirrus HD-OCT 4000/Cirrus HD-OCT 5000, RTVue-XR optical coherence tomography respectively.The primary outcomes were BCVA and VFI, and the secondary outcomes were pRNFL, RPC, and the side effects during the follow-up.The study adhered to the Declaration of Helsinki.All patients were fully informed about the treatment and purpose of this study and voluntarily signed the informed consent form.The study protocol was approved by Chinese PLA General Hospital (No.S2020-021-01). Results:In all, 242 patients (242 eyes) completed the follow-up of BCVA, and 98 patients (98 eyes) completed the VFI follow-up.In terms of visual function, BCVA and VFI improved significantly over time in the two groups, and BCVA and VFI were better in experimental group than in control group at various follow-up time points (all at P<0.05). In terms of structure, pRNFL gradually decreased in both groups with the extension of treatment, and pRNFL was significanthy thinner in experimental group than in control group at various follow-up time points (all at P<0.05). There was no significant difference in RPC between the two groups at the last follow-up ( P>0.05). There were two cases with side effects and one case was discontinued due to side effects 25 days after enrollment. Conclusions:Oral anisodine hydrobromide can improve visual acuity and visual field in NAION and accelerate the regression of optic disc edema, with good safety.

Background: Eradication of Helicobacter pylori (Hp) effectively is becoming exceedingly challenging due to the increase in antibiotic resistance and recurrence of Hp infection. Aims: To explore the effect of an oxygen-enriched environment established by hydrogen peroxide (H

Objective:To examine the correlation of the severity of ulcerative colitis (UC) under endoscopy with blood routine, coagulation, lipid, uric acid and other laboratory indexes.Methods:Clinical data of 90 UC patients in The Second Affiliated Hospital of Xi′an Jiaotong University from January to December 2018 were retrospectively collected. The patients were divided into three groups as light, medium and heavy according to Mayo colonoscopy score. The laboratory indexes were compared among 3 groups and the correlations between Mayo colonoscopy score and laboratory indexes were analyzed.Results:Among light, medium, and heavy groups, differences of the platelet count [ (205.00 ± 61.18) × 10 9/L vs. (240.33 ± 82.90) × 10 9/L vs. (285.55 ± 107.60) × 10 9/L, P=0.020], hemoglobin [ (129.70 ± 16.22) g/L vs. (135.35 ± 20.40) g/L vs. (121.33 ± 27.82) g/L, P=0.034], low-density lipoprotein (LDL) [ (2.44 ± 0.50) mmol/L vs. (2.54 ± 0.67) mmol/L vs. (2.10 ± 0.62) mmol/L, P=0.010], cholesterol [ (4.07 ± 0.60) mmol/L vs. (4.02 ± 0.94) mmol/L vs. (3.50 ± 0.80) mmol/L, P=0.017], fibrinogen [ (2656.00 ± 371.54) mg/L vs. (3034.50 ± 826.52) mg/L vs. (3390.26 ± 1013.61) mg/L, P=0.039] were statistically significant (all P<0.05) . Mayo colonoscopy score was negatively correlated with LDL and cholesterol (all P<0.05) , while it was positively correlated with platelet count and fibrinogen (all P<0.05) . Conclusion:Testing the relevant laboratory indexes of UC patients can help evaluate the intestinal condition.

Objective:To examine the correlation of the severity of ulcerative colitis (UC) under endoscopy with blood routine, coagulation, lipid, uric acid and other laboratory indexes.Methods:Clinical data of 90 UC patients in The Second Affiliated Hospital of Xi′an Jiaotong University from January to December 2018 were retrospectively collected. The patients were divided into three groups as light, medium and heavy according to Mayo colonoscopy score. The laboratory indexes were compared among 3 groups and the correlations between Mayo colonoscopy score and laboratory indexes were analyzed.Results:Among light, medium, and heavy groups, differences of the platelet count [ (205.00 ± 61.18) × 10 9/L vs. (240.33 ± 82.90) × 10 9/L vs. (285.55 ± 107.60) × 10 9/L, P=0.020], hemoglobin [ (129.70 ± 16.22) g/L vs. (135.35 ± 20.40) g/L vs. (121.33 ± 27.82) g/L, P=0.034], low-density lipoprotein (LDL) [ (2.44 ± 0.50) mmol/L vs. (2.54 ± 0.67) mmol/L vs. (2.10 ± 0.62) mmol/L, P=0.010], cholesterol [ (4.07 ± 0.60) mmol/L vs. (4.02 ± 0.94) mmol/L vs. (3.50 ± 0.80) mmol/L, P=0.017], fibrinogen [ (2656.00 ± 371.54) mg/L vs. (3034.50 ± 826.52) mg/L vs. (3390.26 ± 1013.61) mg/L, P=0.039] were statistically significant (all P<0.05) . Mayo colonoscopy score was negatively correlated with LDL and cholesterol (all P<0.05) , while it was positively correlated with platelet count and fibrinogen (all P<0.05) . Conclusion:Testing the relevant laboratory indexes of UC patients can help evaluate the intestinal condition.