OBJECTIVE To comprehensively assess the rationality and safety of clinical application of ceftazidime-avibactam(CAZ/AVI)so as to provide bases for reasonable and safe application of the drugs.METHODS A total of 137 patients who were hospitalized in Tianjin First Central Hospital and were treated with CAZ/AVI from Jan.2023 to Jan.2024 were recruited as the research subjects.The relevant informations involving the baseline da-ta,infection sites,etiological tests,status of drug utilization and adverse reactions were investigated and statically analyzed.The rating form was designed based on relevant guideline consensus and package insert,and the rational-ity and safety of clinical application of days were evaluated.RESULTS Totally 137 valid cases were enrolled in the study,88(64.23％)of whom were male,and 49(35.77％)were female,with the mean age(52±21.89)years old and the average medication duration(12.2±6.45)days.Totally 79 case-times of drug administration were un-reasonable,involving 75 patients;unsuited indications,unreasonable treatment course,absence of special consul-tation and ward round records and no curative effect evaluation after drug administration for 48-72 hours were the major manifestations.The total effective rate of CAZ/AVI treatment was 87.62％,5 patients had CAZ/AVI-associated adverse reactions,with the incidence of adverse reactions 3.65％.CONCLUSION It is necessary for the hospital to further standardize and optimize the clinical utilization of CAZ/AVI,strictly conform to the medica-tion indications,and strengthen the medication surveillance so as to raise the rationality and safety of medication.

OBJECTIVE To comprehensively assess the rationality and safety of clinical application of ceftazidime-avibactam(CAZ/AVI)so as to provide bases for reasonable and safe application of the drugs.METHODS A total of 137 patients who were hospitalized in Tianjin First Central Hospital and were treated with CAZ/AVI from Jan.2023 to Jan.2024 were recruited as the research subjects.The relevant informations involving the baseline da-ta,infection sites,etiological tests,status of drug utilization and adverse reactions were investigated and statically analyzed.The rating form was designed based on relevant guideline consensus and package insert,and the rational-ity and safety of clinical application of days were evaluated.RESULTS Totally 137 valid cases were enrolled in the study,88(64.23％)of whom were male,and 49(35.77％)were female,with the mean age(52±21.89)years old and the average medication duration(12.2±6.45)days.Totally 79 case-times of drug administration were un-reasonable,involving 75 patients;unsuited indications,unreasonable treatment course,absence of special consul-tation and ward round records and no curative effect evaluation after drug administration for 48-72 hours were the major manifestations.The total effective rate of CAZ/AVI treatment was 87.62％,5 patients had CAZ/AVI-associated adverse reactions,with the incidence of adverse reactions 3.65％.CONCLUSION It is necessary for the hospital to further standardize and optimize the clinical utilization of CAZ/AVI,strictly conform to the medica-tion indications,and strengthen the medication surveillance so as to raise the rationality and safety of medication.

The elderly are susceptible to a variety of diseases and the problem of multiple medications is common. Therefore, the rational use of medications in the elderly, especially the rational use of anti-bacterial drugs, is very important. The elderly have unique physiological and pathological characteristics. The decrease of immune function with aging and various factors such as malnutrition, primary disease, decreased mucosal barrier function, weakened cough reflex, and functional changes of the urinary tract system may increase the chance of infection in the elderly. Recommendations for the application of antibacterial drugs in the elderly include strictly grasping of the indications and selecting drug carefully, being alert to adverse drug-drug interactions, paying attention to the safety of drugs in new indications, and formulating individualized therapeutic regimen, etc. The irrational use of antibiotics not only increases the economic burden of patients, but also directly leads to the emergence of bacterial resistance. Clinicians should strictly grasp the indications of antibiotics, monitor the blood drug concentration as much as possible, formulate individualized drug administration plan, and pay attention to medication monitoring, so as to promote the medication safety in the elderly.

The elderly are susceptible to a variety of diseases and the problem of multiple medications is common. Therefore, the rational use of medications in the elderly, especially the rational use of anti-bacterial drugs, is very important. The elderly have unique physiological and pathological characteristics. The decrease of immune function with aging and various factors such as malnutrition, primary disease, decreased mucosal barrier function, weakened cough reflex, and functional changes of the urinary tract system may increase the chance of infection in the elderly. Recommendations for the application of antibacterial drugs in the elderly include strictly grasping of the indications and selecting drug carefully, being alert to adverse drug-drug interactions, paying attention to the safety of drugs in new indications, and formulating individualized therapeutic regimen, etc. The irrational use of antibiotics not only increases the economic burden of patients, but also directly leads to the emergence of bacterial resistance. Clinicians should strictly grasp the indications of antibiotics, monitor the blood drug concentration as much as possible, formulate individualized drug administration plan, and pay attention to medication monitoring, so as to promote the medication safety in the elderly.

OBJECTIVE:To investigate ADR induced by dasatinib,and to provide reference for clinical rational drug use. METHODS:By means of literature metrology method,dasatinib-induced ADR cases domestically and internationally reported were analyzed. RSEULTS:A total of 63 ADR cases were induced by dasatinib,and the age of patients were mainly 41-60 years old. The most cases(25.4%)occurred within 1 month of medication. The patients mainly were from Asian countries and regions(53.9%). Organs/systems involved in dasatinib induced ADRs were mainly respiratory system(40.1%),digestive system(17.5%)and hema-tologic system(11.7%). Main clinical manifestations were pleural effusion(23 cases),pulmonary artery hypertension(15 cases), expiratory dyspnea(8 cases),diarrhea(8 cases),etc. CONCLUSIONS:Daring the use of dasatinib,great importance should be attached to ADR monitoring and prevention so as to avoid serious ADR.