Objective To analyze the number and quality of biomedical journals of different countries,so as to evaluate the situation of their biomedical research.Methods We searched and analyzed the Journal citation report published by Thomson Reuters. The information of biomedical journals of four countries:China,Japan,India,and South Korea,was collected,and was subjected to statistical analysis.Results It was found that China had the least number of biomedical journals,and it accounted for the lowest ratio of its total journals.However,the quality of Chinese biomedical journals was in the lead among the four countries.The impact factor of Chinese journals was obviously higher than those of the other three groups.Compared with Japan,the numbers of Chinese biomedical journals was less for different academic areas.Conclusion China has comparatively small number of SCI-indexed biomedical journals, and the situation should be improved from both number and quality aspects,so that our biomedical journal become a part of the interna-tional biomedical publishing community.

Objective To study the differentially expressed microRNA (miRNA) between pancreatic ductal adenocarcinoma (PDAC) and para-cancerous tissues,and determine related target genes.Methods Nine fresh PDAC tumor tissues and 3 adjacent normal pancreatic tissues were collected,then Agilent miRNAmicroarray with 713 miRNA loci was used to identify the differentially expressed miRNA.Real-time PCR method was applied to verify the up-regulated miRNA.TargetScan 5.1 and miRandaV5 software were used to analyze the related target genes.Results miRNA microarray identified 11 PDAC related miRNAs,among them,the expressions of miR-194*,miR-192*,miR-602,miR-194 were up-regulated,while the expressions of miR-139-3p,miR-513a-5p,miR-630,miR-30c-1 *,miR-887,miR-508-5p,miR-516a-5p were down-regulated.The expressions of miR-192,miR-194 and their homolog were verified in 31 PDAC tumor tissues.After software analysis,it was found that target genes of miR-192 were ZEB2,CXCL-2,EEF1A1,ERCC3,and target genes of miR-192 * were DCC,SMAD4,FAS,and target genes of miR-194 included DACHI,IGSF11,PTPN2,RBBP4,while target genes of miR-194 * included CD40LG,CIDEB,FHL1.Conclusions Eleven differentially expressed miRNAs are present in PDC,and they may be involved in the occurrence and development of PDC.