1.Analysis of Influencing Factors on TCM Syndromes of Chronic Gastritis from the Perspective of Five Circuits and Six Qi
Zhanbo YU ; Yingrong LAO ; Zhaoxi LIU ; Minran HE ; Danghan XU ; Lili WANG
Journal of Guangzhou University of Traditional Chinese Medicine 2025;42(11):2689-2696
Objective To explore the correlation between traditional Chinese medicine(TCM)syndromes of chronic gastritis and the indicators of five circuits and six qi,revealing the influence of different congenital qi endowments on TCM syndrome differentiation and providing evidence for individualized treatment.Methods Medical records meeting inclusion/exclusion criteria were collected from the Hospital Information System(HIS)of Rui Bao Street Community Health Service Center in Haizhu District,Guangzhou between January 20,2017 and January 20,2023.Data included age,birth date,and syndrome differentiation.Yearly circuit(Suiyun),celestial control-terrestrial effect(Sitian-Zaiqian)qi,three patterns of five circuits(Wuyun-Sanji),and syndrome patterns were statistically analyzed using Excel for database construction,with SPSS 23.0 for x2 tests and Logistic regression.Results(1)Among 1 882 chronic gastritis patients,spleen-stomach weakness(25.3%,477/1 882)was the most prevalent syndrome,followed by liver-stomach disharmony type,damp-heat in the spleen-stomach type,stomach-yin deficiency type,and stasis obstruction of stomach collateral type(x2=69.950,P=0.000).(2)Significant differences existed in Suiyun(Taijiao,Taigong,Taiyu,Taizhi,Shaogong,Taishang),Sitian-Zaiqian(Shaoyin-Yangming,Taiyin-Taiyang,Yangming-Shaoyin,Taiyang-Taiyin),and Wuyun-Sanji(excessive/insufficient earth/metal/water circuit)distributions among syndromes(P<0.05 or P<0.01).(3)For Suiyun-syndrome relationships:Birth in Taijiao/Shaogong years was the high-risk factor for developing chronic gastritis of liver-stomach disharmony type(P<0.01);Taishang years were associated with stomach yin deficiency type(P<0.05);Taijiao/Shaogong/Taiyu years were protective against damp-heat in the spleen-stomach type(P<0.05 or P<0.01).(4)For Sitian-Zaiqian-syndrome relationships:Jueyin-Shaoyang/Yangming-Shaoyin years linked to spleen-stomach weakness type(P<0.05);Shaoyang-Jueyin years were correlated with damp-heat in the spleen-stomach type(P<0.05).(5)For Wuyun-Sanji-syndrome relationships:Insufficient earth/water circuit years were associated with liver-stomach disharmony type(P<0.05 or P<0.01);excessive/balanced metal circuit years linked to stomach yin deficiency type(P<0.05 or P<0.01);insufficient metal circuit years were correlated with damp-heat in the spleen-stomach type(P<0.05).Conclusion TCM syndromes of chronic gastritis are influenced by environment-body interactions,disordered visceral function and yin-yang imbalance.Clinical treatment should integrate the varied indicators of five circuits and six qi variations for personalized regimens to improve symptoms and quality of life.
2.Effect of sling exercise with Tuina therapy on kinesiophobia in old patients with lumbar disc herniation:a ran-domized controlled trial based on concept of brain-bone axis
Yuqin DAN ; Jianing SU ; Yi DING ; Xueyan WANG ; Danghan XU ; Jinghua WANG ; Yujing WU ; Mengyuan ZHANG ; Meng YIN ; Haifeng LU ; Gongchang YU ; Li LI
Chinese Journal of Rehabilitation Theory and Practice 2024;30(7):861-868
Objective To explore the effect of sling exercise with Tuina therapy on kinesiophobia in old patients with lumbar disc herniation,and analyze the mechanism based on brain-bone axis. Methods A total of 56 old patients with chronic lumbar disc herniation and kinesiophobia were selected from the Reha-bilitation Hospital of the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine from September,2022 to December,2023;and randomly divided into control group(n=28)and experimental group(n=28).The control group accepted conventional exercise therapy,while the experimental group accepted sling exercise with Tuina therapy,for four weeks.They were assessed with simplified Chinese version of Tampa Scale of Kinesiophobia(TSK),Japanese Orthopaedic Association score(JOA)and Visual Analogue Scale for pain(VAS)before and after treatment,while the bone mineral density(BMD)was tested,the levels of osteoprote-gerin(OPG),norepinephrine(NE)and corticosteroids(Cor)in serum were measured,and the median frequency(MF)of weak-link erector spinae was detected with surface electromyography. Results Two cases dropped off in the control group,and one in the experimental group.The scores of all the assessment improved in both groups after treatment(|t|>14.168,P<0.001),as well as the serum levels of OPG,NE and Cor(|t|>2.103,P<0.05),BMD(|t|>2.726,P<0.05),and MF of erector spinae(|t|>14.736,P<0.001);all of them were better in the experimental group than in the control group(|t|>2.154,P<0.05). Conclusion Sling exercise with Tuina therapy can improve the pain and kinesiophobia of lumbar disc herniation in the old adults,which may promote the recovery of physical and mental function through regulating the levels of hor-mones and neurotransmitters related to the brain-bone axis.
3.ZHUANG Lixing's Experience in Differentiating and Treating Levodopa-Induced Dyskinesia in Parkinson's Disease
Danghan XU ; Jialing LI ; Lining DUAN ; Nanbu WANG ; Haitao TU ; Zhanqiong XU ;
Journal of Traditional Chinese Medicine 2023;64(21):2179-2183
This paper summarized Professor ZHUANG Lixing's clinical experience in differentiating and treating levodopa-induced dyskinesia (LID) in Parkinson's disease. It is believed that the fundamental pathogenesis of LID lies in the disharmony or malnourishment of tendons and vessels. Based on the clinical manifestations, peak-dose LID is differentiated into two syndromes: syndrome of hyperactive liver yang causing wind and syndrome of deficiency of both liver and kidney. For the syndrome of hyperactive liver yang causing wind, the treatment focuses on calming the liver to stop the wind, and relaxing the tendons to stop tremors. The main prescription used is Zhengan Xifeng Decoction (镇肝熄风汤) with the addition of Shijueming (石决明) and Zhenzhumu (珍珠母). For the syndrome of deficiency of both liver and kidney, the treatment focuses on nourishing the liver and kidneys, and replenishing yin to stop the wind. The main prescription used is Dabuyin Pills (大补阴丸) with modification. LID in the acoustic phase is differentiated into syndrome of phlegm-damp blocking middle jiao and syndrome of deficiency of both qi and yin. For the syndrome of phlegm-damp blocking middle jiao, the treatment focuses on dissipating phlegm and eliminating dampness, and nurturing tendons and vessels. Wendan Decoction (温胆汤) or Erchen Decoction (二陈汤) with modification is used. For the syndrome of deficiency of both qi and yin, the treatment focuses on replenishing qi and nourishing blood, and nurturing tendons and vessels. The main prescriptions used are Buzhong Yiqi Decoction (补中益气汤) or Bazhen Decoction (八珍汤) or Shenling Baizhu Powder (参苓白术散) with modification. Biphasic LID is differentiated as the Shaoyang pivot disadvantageousness, and the treatment focuses on harmonizing Shaoyang and regulating the pivot. The main prescription used is Xiaochaihu Decoction (小柴胡汤) with modification.
4.Establishment of a novel composite rat model of chronic skeletal muscle injury
Jingjing LU ; Chi ZHANG ; Chiming ZHANG ; Danghan XU ; Yuxiang LIN ; Weixing XIE
Acta Laboratorium Animalis Scientia Sinica 2023;31(11):1399-1407
Objective To establish a novel rat model of chronic skeletal muscle composite injury in the lumbar region,to explore its mechanism and treatment method in depth.Methods Twenty-eight SD rats were randomly divided into control group(n = 10),Hitting injury model(HIM)group(n = 9),Composite damage model(CDM)group(n = 9)(vertical blow combined with forced prolonged sitting).Open field test,HE staining and PCR sequencing were performed 3 days after modeling.Results The open field distance of rats in HIM group was significantly shorter than that in the CDM group,and both groups had shorter distances than the control group.HE staining showed multiple muscle fiber breaks,significant widening of muscle gaps,uneven distribution of muscle nuclei,and visible congestion in the model group of simple blow injury;In the CDM group,muscle fibers were ruptured,the muscle gaps were slightly widened,and inflammatory cell infiltration was observed between the muscles,especially around the muscle fiber breakage,with muscle fiber nuclei gathering.A volcano plot of the sequencing result suggested significant differences in the Pf4 gene.GO analysis of muscle tissue in model group rats showed upregulation of oxygen binding and carrier activity pathways.Conclusions This study attempted to establish a composite skeletal muscle injury model to study the pathological changes of chronic skeletal muscle injury in the low back pain and evaluate the efficacy of treatment method.It has practical application value in animal experiments for chronic non-specific low back pain.

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