Objective To analyze the clinical characteristics and related to risk factors of late-life depression patients with venous thromboembolism in the elderly ward.Methods A retrospective analysis was conducted on 143 hospitalized depression patients(aged≥60 years)including 65 depression patients with VTE(VTE group)and 78 depression patients without VTE(control group)in the elderly ward of Beijing Anding Hospital from January 2023 to September 2023.The clinic and laboratory data was collected such as general demographic information,relevant clinical data,VTE history,personal history,thyroid function,hormone levels,blood lipid levels and D-dimer to analyze and compare the clinical characteristics of two group patients,and Logistic regression was used to analyze the related risk factors of VTE in patients with depression.Results Compared with control group,patients in the VTE group were older[(70.94±5.88)years vs.(68.04±4.92)years,P<0.05],had a higher total HAMD score(26.35±9.28 vs.23.19±5.94,P<0.05),a higher proportion of a history of VTE[13 cases(20.0%)vs.6 cases(7.7%),P<0.05],a higher proportion of bedridden for more than 72 hours[42 cases(64.6%)vs.31 cases(39.7%),P<0.05],lower HDL-C levels[(1.27±0.27)mmol/L vs.(1.39±0.28)mmol/L,P<0.05],and higher levels of D-dimer[1.91(0.82,3.51)mg/L FEU vs.0.48(0.25,0.80)mg/L FEU,P<0.05].Logistic regression analysis showed that total HAMD scores(OR=1.077,P=0.018),history of VTE(OR=4.339,P=0.023),bedridden for more than 72 hours(OR=2.449,P=0.044),and D-dimer level(OR=2.404,P<0.001)were risk factors for hospitalized late-life depression patients with VTE in the elderly ward.Conclusions Depression patients with VTE in the elderly ward have several clinical characteristics including older age,more severe depressive symptoms,lower HDL-C levels,higher D-dimer levels,and higher proportion of a history of VTE and bedridden for more than 72 hours.Depressive symptoms,a history of VTE,bedridden for more than 72 hours,and D-dimer levels may be risk factors for late-life depression patients with VTE in the elderly ward.

Childhood is an important period of the development of attention, memory, intelligence and other neurocognitive functions in life.A normal neurocognitive development can have a positive impact on children′s long-term learning and life.Therefore, it is very important to concern the development process of neurocognition in children, which is challenging to be objectively assessed without an accurate and efficient index.Sleep slow wave activity, as a kind of electroencephalogram measurement index, is of great significance to the evaluation of brain structure and function in children, and it is also a high-quality index to evaluate children′s neurocognitive development.This study mainly reviews the evaluation of sleep slow wave activity in children′s neurocognitive development, aiming to provide refe-rence for exploring the normal and abnormal process of children′s neurocognitive development.

Objective:To explore the clinical efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) combined with selective serotonin reuptake inhibitors (SSRIs) in the treatment of first-episode late-life depression.Methods:From June 2019 to January 2020, first-episode elderly patients with depression in Beijing Anding Hospital affiliated to Capital Medical University were screened and randomly divided into test group (true rTMS+SSRIs, n=26) and control group (rTMS sham+SSRIs, n=25) according to the random number table method. All the patients were treated for 4 weeks and followed up for 4 weeks after treatment. The test group received 20 sessions (5 sessions per week) of 10 Hz rTMS (120% of motor threshold). Hamilton Depression Scale (HAMD 17) and The Patient Health Questionnaire-9 (PHQ-9) were used to assess the clinical symptoms at the end of the 1st, 2nd, 3rd and 4th week of treatment and at the end of the 4th week of the follow-up after treatment, and the response rate and the rate of recovery were compared between the two groups,analyzed by the χ 2 test and repeated measurement analysis of variance. Results:(1) At the end of the 4th week of treatment 69.23% (18/26) subjects in the test group and 36.00% (9/25) in the control group significantly improved their depressive condition, which was defined as a more than 50% HAMD 17 reduction (χ 2=5.649, P=0.017). However, there was no significant difference between the two groups when compared the rate of recovery,which was defined as a HAMD 17 ≤7 ( P>0.05). (2) At the end of the 4th week of the follow-up, there was no significant difference in the response rate nor the rate of recovery between the two groups ( P>0.05). (3) During the entire observation period, there was an interaction between the time point and the group in HAMD 17 total score and PHQ-9 total score ( F=66.313, P=0.008; F=8.571, P<0.01). Conclusion:There might be potential advantages in the combination treatments by rTMS at 120% MT and SSRIs antidepressants for the elderly depressive patients, and the onset of efficacy is faster than that of pharmacotherapy alone, while the large sample clinical studies are still needed to confirm the benefits.

Objective:To explore the clinical efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) combined with selective serotonin reuptake inhibitors (SSRIs) in the treatment of first-episode late-life depression.Methods:From June 2019 to January 2020, first-episode elderly patients with depression in Beijing Anding Hospital affiliated to Capital Medical University were screened and randomly divided into test group (true rTMS+SSRIs, n=26) and control group (rTMS sham+SSRIs, n=25) according to the random number table method. All the patients were treated for 4 weeks and followed up for 4 weeks after treatment. The test group received 20 sessions (5 sessions per week) of 10 Hz rTMS (120% of motor threshold). Hamilton Depression Scale (HAMD 17) and The Patient Health Questionnaire-9 (PHQ-9) were used to assess the clinical symptoms at the end of the 1st, 2nd, 3rd and 4th week of treatment and at the end of the 4th week of the follow-up after treatment, and the response rate and the rate of recovery were compared between the two groups,analyzed by the χ 2 test and repeated measurement analysis of variance. Results:(1) At the end of the 4th week of treatment 69.23% (18/26) subjects in the test group and 36.00% (9/25) in the control group significantly improved their depressive condition, which was defined as a more than 50% HAMD 17 reduction (χ 2=5.649, P=0.017). However, there was no significant difference between the two groups when compared the rate of recovery,which was defined as a HAMD 17 ≤7 ( P>0.05). (2) At the end of the 4th week of the follow-up, there was no significant difference in the response rate nor the rate of recovery between the two groups ( P>0.05). (3) During the entire observation period, there was an interaction between the time point and the group in HAMD 17 total score and PHQ-9 total score ( F=66.313, P=0.008; F=8.571, P<0.01). Conclusion:There might be potential advantages in the combination treatments by rTMS at 120% MT and SSRIs antidepressants for the elderly depressive patients, and the onset of efficacy is faster than that of pharmacotherapy alone, while the large sample clinical studies are still needed to confirm the benefits.

BACKGROUND:Overproduction of thyroid hormones is shown to increase the activities of osteoblasts and osteoclasts, stimulating bone resorption and transformation. Inadequate compensation of increased bone resorption by bone transformation results in an increased loss of bone mass.
OBJECTIVE:To investigate the effects of hyperthyroidism on the density of the alveolar bone.
METHODS:Twenty-four New Zealand rabbits were equal y randomized into hyperthyroidism group and control group. Rabbits in the hyperthyroidism group or control group were daily injected intraperitoneal y with 50μg/kg levothyrocine diluted in physiological saline solution or equal volume of physiological saline. At 8 weeks after treatment, serum levels of thyroid hormones (FT3 and FT4), alkaline phosphatase, magnesium and calcium, phosphorus were determined;meanwhile, the bone densities of the lumbar vertebra, mandible, bilateral distal femur were determined by dual energy X-ray absorptiometry and the correlation analysis was performed.
RESULTS AND CONCLUSION:At 8 weeks after treatment, serum levels of FT3, FT4, alkaline phosphatase calcium, phosphorus, and magnesium in the hyperthyroidism group were significantly increased (P<0.01), while the bone densities of the lumbar vertebra, mandible, bilateral distal femur were significantly decreased (P<0.05), compared with the control group. Bone density of the mandible was positively correlated with the bone density the lumbar vertebra and bilateral distal femur. These findings suggest that the changes in FT3 and FT4 are sufficient for the diagnosis of hyperthyroidism. Hyperthyroidism results in the decreased density of the alveolar bone, indicating the occurrence of osteoporosis.

We studied the epidemiological characteristics of human bocavirus 4 (HBoV4) in children with a- cute gastroenteritis in Lanzhou (China). A total of 331 stool specimens were collected from children aged < 5 years with acute diarrhea at the First Hospital of Lanzhou University between July 2012 and June 2013. Specimens of HBoV were identified by nested polymerase chain reaction assays. Compared with related sequences in GenBank, the HBoV-positive strain isolated in the present study was,quite surprisingly, a rare genotype named HBoV4. This strain was a typical HBoV4,with high levels of nucleotide and amino acid homology to the Thailand strain, JQ267789 (98.9% and 98.7%, respectively), and the USA strain, GQ506568 (97.6% and 97.4%, respectively). This is the first report of HBoV4 as the causative agent for acute gastroenteritis in pediatric patients in China. This strain is one of two genotypes of HBoV that are currently circulating.
Child, Preschool ; China ; Feces ; virology ; Female ; Gastroenteritis ; virology ; Human bocavirus ; classification ; genetics ; isolation & purification ; Humans ; Infant ; Male ; Molecular Sequence Data ; Parvoviridae Infections ; virology ; Phylogeny

Objective To explore the evolutionary and molecular characteristics of rare RVA genetype G9P[6] (LL51695) isolated in our laboratory.Methods Major genome segments of RVA strain LL51695 was amplified by reverse transcription-polymerase chain reaction (RT-PCR),and the segments were sequenced.The genome segments of LL51695 was determined by the online RotaC genotyping tool (RotaC v2.0).The reference sequences of every genome segments of RVA was downloaded from GenBank.Homology and phylogenetic evolutionary analyses were conducted using the MEGA 5.0 and DNAStar software package.Results LL51695 isolated from human in Lulong is a rare genotype constellation:G9-P[6]-I5-E1.Conclusion The VP7,VP4,VP6,NSP4 genes were all porcine origins,the strain may be porcine rotaviruses direct infect human.

Objective To study the main genes molecular characteristics and evolutionary relationship of porcine and human group A rotavirus (GARV) type G9 in Hebei Lulong region.Methods A stool specimen from diarrhea piglet marked as LLP48 in 2008 in Hebei Lulong region,which was G9 GARV positive and 4 stool specimens collected from hospitalized children with diarrhea under the age of five from 2009 to 2011 in Lulong region which were type G9 GARV positive were selected and the main genes were amplified by RT-PCR.After sequencing,the obtained genes were analyzed through MEGA,DNAStar software and other biological sequence alignment,homology and phylogenetic analyses were performed.Results Porcine GARV LLP48 in Lulong region and four strains of Lulong human GARV were highly homologous in VP7,VP6,NSP4 and NSP2 gene fragments,and nucleotide and amino acid homology respectively was 89.4％-94％ and 94.8％-98.2％ ; VP4 fragment of the nucleotide homology (amino acid) is low,71.4％-71.6％ (68.2％-69.0％).Phylogenetic analysis showed that LLP48 genes encoding VP7,VP6,NSP4 and NSP2 were closely related to the strain derived from human source,and VP4 gene closely related to the strains derived from porcine source.Conclusion Lulong porcine GARV LLP48 strain may be a natural reassorted product of porcine VP4 and human VP7,VP6,NSP4 and NSP2.