Objective To study the treatment outcome and endoscopic characteristics of Helicobacter pylori(Hp)after endoscopic resection in the patients with early gastric cancer.Methods The 82 patients with early-stage gastric cancer who had Hp infection history and received the standardized Hp radical treatment in the Sixth Affiliated Hospital of Nantong University and the Affiliated Hospital of Nantong University from January 2021 to July 2023 served as the research subjects.The patients with carbon 13 breath test negative re-sults after Hp eradication treatment were included in the Hp eradication group(n=60),and the patients with positive results of rapid urease test,Hp fecal antigen test or carbon 13 breath test under gastroscopy were in-cluded in the Hp non-eradication group(n=22).The clinical and endoscopic characteristic data and the preva-lence rate of uncertain gastric cancer by targeted biopsy were compared between the two groups.Results There was no statistically significant difference in the gender,age and atrophy degree between the two groups(P＞0.05).There were statistically significant differences in the lesion location,macroscopic type,color tone and tumor size between the two groups(P＜0.05).Among them,the proportion of the lower 1/3 of stomach in the Hp eradication group was the highest(53.33％),while the proportion of the upper 3/1 of the stomach in the Hp non-eradication group was the highest(63.64％).In terms of macroscopic type,the proportion of depression type in the Hp eradication group was the highest(65.00％),while the proportion of uplift type in the Hp non-eradication group was the highest(59.09％).In terms of hue,the proportion of red in the Hp eradication group was the highest(83.33％).The proportion of tumor diameter＜20 mm in the Hp eradication group was higher(76.67％),while the proportion of tumor diameter 20 mm in the Hp non-eradication group was higher(72.73％).During the pretreatment endoscopy period,the prevalence rate of un-diagnosed gastric cancer by targeted biopsy in the Hp eradication group was 28.33％(17/60),which was higher than 4.55％(1/22)in the Hp non-eradication group,and the difference was statistically significant(X2=4.019,P=0.045).Conclusion Hp eradication has an important influence on the diagnosis of early gas-tric cancer.