Spinal cord injury often leads to permanent disability or death,which can cause heavy burden to the family and society.Currently,there is no cure for spinal cord injury,the main purpose of the treatment is to preserve the residual function of the spinal cord to the greatest extent.In this review,the recent advances of the therapy of spinal cord injury will be elaborated in two aspects,including the neuroprotection and the neuranagenesis,and the past treatment strategies will be reassessed,in order to strengthen the understanding of the treatment of spinal cord injury,so as to provide a reference for the formulation of more effective clinical therapy.

Objective To explore the microstructural changes of brain white matter in first-episode of childhood and adolescence-onset schizophrenia and the relationship between the fractional anisostrapy (FA)values and cognitive function in patients.Methods This study was a case-control study,40 childhood and adolescence-onset schizophrenia patients aged 10-16 years 35 healthy children with sex,age,education and race matched to controls were chosen. All the subjects were conducted diffusion tensor imaging (DTI) scans, then using tract-based spatial statistics (TBSS) method to compare FA values of white matter fiber. The cognitive function was assessed with the (MATRICS Consensus Cognitive Battery,MCCB). The relationship between the FA values of different white matter and the cognitive function in the two group was analysed by using Pearson correlation analysis. Results Compared with the controls(n=34), FA values of patients(n=35) in the body of corpus callosum, genu of corpus callosum, splenium of corpus callosum, cingulum bundle, right upper corona radiate, upper left corona radiate significantly decreased (t=4.726, 2.855,2.547,2.943,3.178,2.969,all P<0.05).The FA values of the body of corpus callosum were positively correlated with the symbol coding, color, color words(r=0.34, 0.38, 0.36, all P<0.05) in patients. The FA value of the cingulum bundle were positively correlated with the Hapkins Verbal Learning Test-Revised (HVLT-R),the FA value of the upper left corona radiate were positively correlated with the Word fluency(r=0.34,0.37,both P<0.05).In the controls FA value of white matter in the body and genu of corpus callosum were positively correlated with the HVLT-R(r=0.34,0.51,both P<0.05).Conclusions The childhood and adolescence-onset schizophrenia showed microstructural changes in the brain regional white matter, the pathophysiological mechanism of cognitive impairment may be related to the abnormalities of the brain white matter microstructural structure.

Objective To explore the microstructural changes of brain white matter in first-episode of childhood and adolescence-onset schizophrenia and the relationship between the fractional anisostrapy (FA)values and cognitive function in patients.Methods This study was a case-control study,40 childhood and adolescence-onset schizophrenia patients aged 10-16 years 35 healthy children with sex,age,education and race matched to controls were chosen. All the subjects were conducted diffusion tensor imaging (DTI) scans, then using tract-based spatial statistics (TBSS) method to compare FA values of white matter fiber. The cognitive function was assessed with the (MATRICS Consensus Cognitive Battery,MCCB). The relationship between the FA values of different white matter and the cognitive function in the two group was analysed by using Pearson correlation analysis. Results Compared with the controls(n=34), FA values of patients(n=35) in the body of corpus callosum, genu of corpus callosum, splenium of corpus callosum, cingulum bundle, right upper corona radiate, upper left corona radiate significantly decreased (t=4.726, 2.855,2.547,2.943,3.178,2.969,all P<0.05).The FA values of the body of corpus callosum were positively correlated with the symbol coding, color, color words(r=0.34, 0.38, 0.36, all P<0.05) in patients. The FA value of the cingulum bundle were positively correlated with the Hapkins Verbal Learning Test-Revised (HVLT-R),the FA value of the upper left corona radiate were positively correlated with the Word fluency(r=0.34,0.37,both P<0.05).In the controls FA value of white matter in the body and genu of corpus callosum were positively correlated with the HVLT-R(r=0.34,0.51,both P<0.05).Conclusions The childhood and adolescence-onset schizophrenia showed microstructural changes in the brain regional white matter, the pathophysiological mechanism of cognitive impairment may be related to the abnormalities of the brain white matter microstructural structure.