1.Targeted therapies and immunotherapies for unresectable cholangiocarcinoma.
Shengbai XUE ; Weihua JIANG ; Jingyu MA ; Haiyan XU ; Yanling WANG ; Wenxin LU ; Daiyuan SHENTU ; Jiujie CUI ; Maolan LI ; Liwei WANG
Chinese Medical Journal 2025;138(16):1904-1926
Cholangiocarcinoma (CCA) is a fatal malignancy with steadily increasing incidence and poor prognosis. Since most CCA cases are diagnosed at an advanced stage, systemic therapies, including chemotherapy, radiotherapy, targeted therapy, and immunotherapy, play a crucial role in the management of unresectable CCA. The recent advances in targeted therapies and immunotherapies brought more options in the clinical management of unresectable CCA. This review depicts the advances of targeted therapies and immunotherapies for unresectable CCA, summarizes crucial clinical trials, and describes the efficacy and safety of different drugs, which may help further develop precision and individualization in the clinical treatment of unresectable CCA.
Humans
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Cholangiocarcinoma/drug therapy*
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Immunotherapy/methods*
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Bile Duct Neoplasms/drug therapy*
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Molecular Targeted Therapy/methods*
Result Analysis
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