1.Asia-Pacific consensus statement on medication-related osteonecrosis of the jaw in patients with osteoporosis
Akira TAGUCHI ; Daisuke INOUE ; Jin-Woo KIM ; Keskanya KESKANYA ; Wai Sin CHAN ; Hee Dong CHAE ; Chung-Hwan CHEN ; Ching-Lung CHEUNG ; Eddie Siu Lun CHOW ; Yoon-Sok CHUNG ; Linsey GANI ; Muhammad Kamil BIN HASSAN ; Unnop JAISAMRARN ; Chakorn VORAKULPIPAT ; Nutchada SRIYARANYA ; Aasis UNNANUNTANA ; Tanawat AMPHANSAP ; Seng Bin ANG ; Fen Lee HEW ; Julie LI-YU ; Terence Ong Ing WEI ; Jeyakantha JEYAKANTHA ; Mark Anthony SANDOVAL ; Thawee SONGPATANASILP ; Monica Therese CATING-CABRAL ; Thanut VALLEENUKUL ; Lalita WATTANACHANYA ; Chih-Hsing CHIH-HSING ; Weibo XIA ; Jawl-Shan HWANG ; Hiroshi HAGINO ; Natthinee CHARATCHAROENWITTHAYA
Osteoporosis and Sarcopenia 2026;12(1):1-17
A unified consensus statement on medication-related osteonecrosis of the jaw (MRONJ) has not yet been established among the Asian member countries or regions of the Asian Federation of Osteoporosis Societies (AFOS). This study aimed to develop a consensus on MRONJ in patients with osteoporosis across these countries and regions. In this study, the term “Asia-Pacific” refers specifically to the Asian member countries and regions of AFOS. A structured survey consisting of nine MRONJ-related questions was distributed across 10 countries and regions to assess the level of agreement and summarize regional perspectives. In addition, a manual literature review and voting were conducted to evaluate the current evidence on MRONJ. The key aspects of MRONJ, including definition, staging, diagnosis, pathogenesis, risk factors, management, and prevention, were generally consistent among the AFOS countries and regions. The annual incidence and incidence rate of MRONJ associated with low-dose antiresorptive therapy in patients with osteoporosis ranged from 0.025% to 0.136% and 21 to 283 cases per 100,000 person-years, respectively. However, evidence regarding the benefits of drug discontinuation before dental surgery, such as tooth extraction, remains insufficient. Large-scale, multinational studies across AFOS countries and regions are warranted to determine the incidence of MRONJ better and evaluate the impact of antiresorptive drug discontinuation before dental procedures. These findings may contribute to the devel opment of effective evidence-based strategies for preventing MRONJ in patients with osteoporosis.
2.Early Rehabilitation Interventions by Physical Therapists for Severe COVID-19 Patients Were Associated With Decreased Incidence of Post-ICU Physical Impairment
Shinya OKU ; Junji HATAKEYAMA ; Keibun LIU ; Kentaro TOJO ; Masafumi IDEI ; Shigeaki INOUE ; Kazuma YAMAKAWA ; Takeshi NISHIDA ; Shinichiro OHSHIMO ; Satoru HASHIMOTO ; Shuhei MARUYAMA ; Yoshitaka OGATA ; Daisuke KAWAKAMI ; Hiroaki SHIMIZU ; Katsura HAYAKAWA ; Yuji FUJINO ; Taku OSHIMA ; Tatsuya FUCHIGAMI ; Hironori YAWATA ; Kyoji OE ; Akira KAWAUCHI ; Hidehiro YAMAGATA ; Masahiro HARADA ; Yuichi SATO ; Tomoyuki NAKAMURA ; Kei SUGIKI ; Takahiro HAKOZAKI ; Satoru BEPPU ; Masaki ANRAKU ; Noboru KATO ; Tomomi IWASHITA ; Hiroshi KAMIJO ; Yuichiro KITAGAWA ; Michio NAGASHIMA ; Hirona NISHIMAKI ; Kentaro TOKUDA ; Osamu NISHIDA ; Kensuke NAKAMURA
Annals of Rehabilitation Medicine 2025;49(1):49-59
Objective:
To implement early rehabilitation interventions by physical therapists is recommended. However, the effectiveness of early rehabilitation for severe coronavirus disease 2019 (COVID-19) patients in the prevention of post-intensive care syndrome (PICS) is unclear. We analyzed a multicenter prospective observational study (Post-Intensive Care outcomeS in patients with COronaVIrus Disease 2019) to examine the association between early rehabilitation interventions and PICS physical impairment.
Methods:
An analysis was performed on COVID-19 patients who were admitted to intensive care units (ICUs) between March 2020 and March 2021, and required mechanical ventilation. The primary outcome was the incidence of PICS physical impairment (Barthel Index≤90) after one year. Multivariate logistic regression analysis was used to estimate the association between early rehabilitation interventions and PICS physical impairment by adjusting ICU mobility scale (IMS) during seven-day following ICU admission, and clinically relevant risk factors.
Results:
The analysis included 259 patients, 54 of whom developed PICS physical impairment one year later. In 81 patients, physical therapists intervened within seven days of ICU admission. There was no significant difference in mean IMS by day seven of admission between the early and non-early rehabilitation patients (0.70 and 0.61, respectively). Multivariate logistic regression analysis showed that early rehabilitation interventions were significantly associated with a low incidence of PICS physical impairment (odds ratio, 0.294; 95% confidence interval, 0.123–0.706; p=0.006).
Conclusion
Early rehabilitation interventions by physical therapists were an independent factor associated with the decreased development of PICS physical impairment at one year, even though early rehabilitation had no significant effect on IMS.
3.Early Rehabilitation Interventions by Physical Therapists for Severe COVID-19 Patients Were Associated With Decreased Incidence of Post-ICU Physical Impairment
Shinya OKU ; Junji HATAKEYAMA ; Keibun LIU ; Kentaro TOJO ; Masafumi IDEI ; Shigeaki INOUE ; Kazuma YAMAKAWA ; Takeshi NISHIDA ; Shinichiro OHSHIMO ; Satoru HASHIMOTO ; Shuhei MARUYAMA ; Yoshitaka OGATA ; Daisuke KAWAKAMI ; Hiroaki SHIMIZU ; Katsura HAYAKAWA ; Yuji FUJINO ; Taku OSHIMA ; Tatsuya FUCHIGAMI ; Hironori YAWATA ; Kyoji OE ; Akira KAWAUCHI ; Hidehiro YAMAGATA ; Masahiro HARADA ; Yuichi SATO ; Tomoyuki NAKAMURA ; Kei SUGIKI ; Takahiro HAKOZAKI ; Satoru BEPPU ; Masaki ANRAKU ; Noboru KATO ; Tomomi IWASHITA ; Hiroshi KAMIJO ; Yuichiro KITAGAWA ; Michio NAGASHIMA ; Hirona NISHIMAKI ; Kentaro TOKUDA ; Osamu NISHIDA ; Kensuke NAKAMURA
Annals of Rehabilitation Medicine 2025;49(1):49-59
Objective:
To implement early rehabilitation interventions by physical therapists is recommended. However, the effectiveness of early rehabilitation for severe coronavirus disease 2019 (COVID-19) patients in the prevention of post-intensive care syndrome (PICS) is unclear. We analyzed a multicenter prospective observational study (Post-Intensive Care outcomeS in patients with COronaVIrus Disease 2019) to examine the association between early rehabilitation interventions and PICS physical impairment.
Methods:
An analysis was performed on COVID-19 patients who were admitted to intensive care units (ICUs) between March 2020 and March 2021, and required mechanical ventilation. The primary outcome was the incidence of PICS physical impairment (Barthel Index≤90) after one year. Multivariate logistic regression analysis was used to estimate the association between early rehabilitation interventions and PICS physical impairment by adjusting ICU mobility scale (IMS) during seven-day following ICU admission, and clinically relevant risk factors.
Results:
The analysis included 259 patients, 54 of whom developed PICS physical impairment one year later. In 81 patients, physical therapists intervened within seven days of ICU admission. There was no significant difference in mean IMS by day seven of admission between the early and non-early rehabilitation patients (0.70 and 0.61, respectively). Multivariate logistic regression analysis showed that early rehabilitation interventions were significantly associated with a low incidence of PICS physical impairment (odds ratio, 0.294; 95% confidence interval, 0.123–0.706; p=0.006).
Conclusion
Early rehabilitation interventions by physical therapists were an independent factor associated with the decreased development of PICS physical impairment at one year, even though early rehabilitation had no significant effect on IMS.
4.Early Rehabilitation Interventions by Physical Therapists for Severe COVID-19 Patients Were Associated With Decreased Incidence of Post-ICU Physical Impairment
Shinya OKU ; Junji HATAKEYAMA ; Keibun LIU ; Kentaro TOJO ; Masafumi IDEI ; Shigeaki INOUE ; Kazuma YAMAKAWA ; Takeshi NISHIDA ; Shinichiro OHSHIMO ; Satoru HASHIMOTO ; Shuhei MARUYAMA ; Yoshitaka OGATA ; Daisuke KAWAKAMI ; Hiroaki SHIMIZU ; Katsura HAYAKAWA ; Yuji FUJINO ; Taku OSHIMA ; Tatsuya FUCHIGAMI ; Hironori YAWATA ; Kyoji OE ; Akira KAWAUCHI ; Hidehiro YAMAGATA ; Masahiro HARADA ; Yuichi SATO ; Tomoyuki NAKAMURA ; Kei SUGIKI ; Takahiro HAKOZAKI ; Satoru BEPPU ; Masaki ANRAKU ; Noboru KATO ; Tomomi IWASHITA ; Hiroshi KAMIJO ; Yuichiro KITAGAWA ; Michio NAGASHIMA ; Hirona NISHIMAKI ; Kentaro TOKUDA ; Osamu NISHIDA ; Kensuke NAKAMURA
Annals of Rehabilitation Medicine 2025;49(1):49-59
Objective:
To implement early rehabilitation interventions by physical therapists is recommended. However, the effectiveness of early rehabilitation for severe coronavirus disease 2019 (COVID-19) patients in the prevention of post-intensive care syndrome (PICS) is unclear. We analyzed a multicenter prospective observational study (Post-Intensive Care outcomeS in patients with COronaVIrus Disease 2019) to examine the association between early rehabilitation interventions and PICS physical impairment.
Methods:
An analysis was performed on COVID-19 patients who were admitted to intensive care units (ICUs) between March 2020 and March 2021, and required mechanical ventilation. The primary outcome was the incidence of PICS physical impairment (Barthel Index≤90) after one year. Multivariate logistic regression analysis was used to estimate the association between early rehabilitation interventions and PICS physical impairment by adjusting ICU mobility scale (IMS) during seven-day following ICU admission, and clinically relevant risk factors.
Results:
The analysis included 259 patients, 54 of whom developed PICS physical impairment one year later. In 81 patients, physical therapists intervened within seven days of ICU admission. There was no significant difference in mean IMS by day seven of admission between the early and non-early rehabilitation patients (0.70 and 0.61, respectively). Multivariate logistic regression analysis showed that early rehabilitation interventions were significantly associated with a low incidence of PICS physical impairment (odds ratio, 0.294; 95% confidence interval, 0.123–0.706; p=0.006).
Conclusion
Early rehabilitation interventions by physical therapists were an independent factor associated with the decreased development of PICS physical impairment at one year, even though early rehabilitation had no significant effect on IMS.
5.Tracking a patient with no technetium-99m-pyrophosphate myocardial uptake at surgical valve replacement for aortic stenosis.
Koji TAKAHASHI ; Daisuke SASAKI ; Takaaki IWAMURA ; Shuhei YAMAMOTO ; Mitsuharu UEDA ; Nobuhisa YAMAMURA ; Mako YOSHINO ; Daijiro ENOMOTO ; Hiroe MORIOKA ; Shigeki UEMURA ; Takafumi OKURA ; Tomoki SAKAUE ; Katsuji INOUE
Journal of Geriatric Cardiology 2025;22(9):828-833
7.A novel technique for posterior lumbar interbody fusion to obtain a good local lordosis angle: anterior-release posterior lumbar interbody fusion
Daisuke INOUE ; Hiroaki MATSUMORI ; Hideki SHIGEMATSU ; Yurito UEDA ; Toshiya MORITA ; Sachiko KAWASAKI ; Masaki IKEJIRI ; Yasuhito TANAKA
Asian Spine Journal 2024;18(5):706-711
Herein, we describe a novel posterior lumbar interbody fusion (PLIF) technique with annulus fibrosus (AF) release and the use of expandable cages (called “anterior-release PLIF” [ARPLIF]). In this technique, posterior column osteotomy (PCO) and AF release provide excellent intervertebral mobility. AF release involves circumferentially peeling off the AF above or below the endplate between the fixed vertebrae under radiographic guidance without cutting the AF and anterior longitudinal ligament. Subsequently, high-angle variable-angle expandable cages are used to simultaneously expand both sides before inserting the percutaneous pedicle screws and correcting to achieve good local lumbar lordosis. PCO and AF release achieve excellent intervertebral mobility. Intervertebral mobility and simultaneous expansion of both cages disperse the force on the endplates, reducing cage subsidence, and the high-angle cages facilitate high intervertebral angle creation. The novel ARPLIF intervertebral manipulation technique can promote good local lumbar lordosis formation.
8.Establishing a Regional Medical Cooperation Network in a Mountainous Area Using an Information Sharing Application Developed by Reflecting the Opinions of Medical and Welfare Professionals
Takeshi TANAKA ; Koichi YAMAGUCHI ; Kazuoki INOUE ; Daisuke SON ; Masahiko KODA ; Shinichi TANIGUCHI
An Official Journal of the Japan Primary Care Association 2022;45(3):102-105
9.The Influence of Posture on Instability Evaluation Using Flexion–Extension X-Ray Imaging in Lumbar Spondylolisthesis
Daisuke INOUE ; Hideki SHIGEMATSU ; Yoshiyuki NAKAGAWA ; Toshichika TAKESHIMA ; Yasuhito TANAKA
Asian Spine Journal 2021;15(3):308-316
Prospective clinical study. To determine the optimal posture for instability evaluation using flexion–extension X-ray imaging in patients with lumbar spondylolisthesis. Currently, flexion–extension X-ray imaging is the most practical approach for the evaluation of lumbar instability. In flexion–extension X-ray imaging, achievement of the greatest segmental motion with flexion–extension movement is necessary. However, to our knowledge, currently, there is no standardized posture for determining lumbar instability. Twenty-three individuals with lumbar spondylosis related to the fourth vertebra underwent flexion–extension X-ray imaging in different postures (standing, sitting, and lateral decubitus positions), lumbar magnetic resonance imaging (MRI), and low back pain Visual Analog Scale (VAS) evaluation on the same day. Intervertebral angle, percent slippage, and intervertebral disc area ratio for different postures during flexion and extension were compared using Tukey’s method. The effect of low back pain and the association between MRI facet effusion and these measurements were investigated according to posture. The percent slippage during extension ( In this study, intervertebral instability was best evaluated in the lateral decubitus position when using flexion–extension X-ray imaging for patients with fourth lumbar vertebral spondylolisthesis.
10.The Influence of Posture on Instability Evaluation Using Flexion–Extension X-Ray Imaging in Lumbar Spondylolisthesis
Daisuke INOUE ; Hideki SHIGEMATSU ; Yoshiyuki NAKAGAWA ; Toshichika TAKESHIMA ; Yasuhito TANAKA
Asian Spine Journal 2021;15(3):308-316
Prospective clinical study. To determine the optimal posture for instability evaluation using flexion–extension X-ray imaging in patients with lumbar spondylolisthesis. Currently, flexion–extension X-ray imaging is the most practical approach for the evaluation of lumbar instability. In flexion–extension X-ray imaging, achievement of the greatest segmental motion with flexion–extension movement is necessary. However, to our knowledge, currently, there is no standardized posture for determining lumbar instability. Twenty-three individuals with lumbar spondylosis related to the fourth vertebra underwent flexion–extension X-ray imaging in different postures (standing, sitting, and lateral decubitus positions), lumbar magnetic resonance imaging (MRI), and low back pain Visual Analog Scale (VAS) evaluation on the same day. Intervertebral angle, percent slippage, and intervertebral disc area ratio for different postures during flexion and extension were compared using Tukey’s method. The effect of low back pain and the association between MRI facet effusion and these measurements were investigated according to posture. The percent slippage during extension ( In this study, intervertebral instability was best evaluated in the lateral decubitus position when using flexion–extension X-ray imaging for patients with fourth lumbar vertebral spondylolisthesis.
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