1.Molecular phylogeny and morphometric divergence of native Korean wild mice (Musmusculus)
Daewoo KIM ; Jooseong OH ; Jang Geun OH ; Hee-Young YANG ; Geun-Joong KIM ; Tae-Hoon LEE ; Bae-Keun LEE ; Chungoo PARK ; Dong-Ha NAM
Laboratory Animal Research 2026;42(1):68-81
Background:
The taxonomic status of house mice (Mus musculus) on the Korean Peninsula has long been debated due to conflicting morphological classifications and limited genetic evidence. Historically, three subspecies (M. m.molossinus, M. m. utsuryonis, and M. m. yamashinai) have been proposed based on external traits, although the validity of these proposals remains uncertain. Thus, this study aimed to integrate genetic and morphological analyses to clarify the phylogenetic relationships of Korean mice relative to the well-known primary M. musculus subspecies and evaluate the taxonomic distinctiveness.
Results:
Genetic analysis of mitochondrial DNA (cytb gene) from mice across Korea, including islands, mountains, and agricultural fields, confirmed that these mice belong to the Eurasian M. m. musculus lineage. Morphologically, Korean mice exhibited tail ratios consistent with previously assigned subspecies, suggesting these traits represent intraspecific variation within M. m. musculus. Craniometric analyses revealed distinctive features, such as a shorter, narrower premaxillary tooth-patch width and a longer maxillary tooth-row length, thereby distinguishing these mice from laboratory strains derived from M. m. domesticus. These cranial configurations, visualized via three-dimensional micro-computed tomography scans, further supported the morphological divergence of these mice from other subspecies.
Conclusions
Our findings indicate that Korean house mice belong to a single subspecific group within M. m.musculus, with observed morphological variations reflecting local adaptation rather than distinct taxonomic divisions.The Korean Peninsula likely served as an ecological bridge, facilitating the spatiotemporal diversification of M. m.musculus across East Eurasia. This study resolves longstanding taxonomic ambiguities and underscores the subspecific status of Korean house mice within M. m. musculus. These insights provide a foundation for understanding the biogeographic history of human commensal species and future biomedical research utilizing wild-derived mouse models.
2.Implant rehabilitation of extensive maxillary bone loss secondary to chronic odontogenic sinusitis using a press-fit autogenous ramal block graft: a multidisciplinary staged approach
Daewoo KIM ; Se Mok OH ; Min Beom KIM ; Hansol OH ; Yongkwon LEE ; Jong Han YU
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2026;52(1):44-50
This report details the implant rehabilitation of a patient with extensive maxillary bone loss secondary to chronic odontogenic sinusitis. Prolonged inflammation rendered the right posterior maxilla unsuitable for spontaneous regeneration, necessitating a staged multidisciplinary intervention. Treatment commenced with sinus management via incision and drainage and a targeted pharmacological regimen. Once clinical resolution was achieved, reconstruction was performed using an autogenous bone block harvested from the right mandibular ramus combined with xenogenic substitutes. A key aspect of the surgical procedure was the utilization of a press-fit fixation technique, where the ramal block was precisely contoured to achieve immediate mechanical stability and screwless fixation through frictional force and mechanical interlocking. The approach was divided into four phases: (1) management of sinusitis; (2) sinus floor elevation and reconstruction using a press-fit autogenous ramal block; (3) implant placement (#16, #17) after a five-month graft maturation period; and (4) final prosthesis delivery after a three-month osseointegration period. The successful outcome demonstrates that predictable functional restoration can be achieved through a planned staged protocol integrating medical management and press-fit bone grafting, even in severe bone deficiency complicated by sinus pathology.
3.Prosthetic rehabilitation of pseudo-Class III malocclusion using tooth- and implant-supported prosthetic restoration in centric relation (CR): a case report
Daewoo KIM ; Semok OH ; Yunshik CHOO ; Yongkwon LEE ; Jonghan YU
Journal of Dental Rehabilitation and Applied Science 2025;41(3):239-247
This report presents the management of a patient with pseudo Class III malocclusion and unstable mandibular movements caused by the lack of a stable occlusal stop. Without posterior support, the mandibular incisors slid along the labial surfaces of the maxillary incisors during centric relation (CR) guidance, resulting in anterior mandibular closure. This pattern presented as a habitual anterosuperior mandibular displacement during voluntary closure. Provisional prostheses for the maxillary anterior teeth and mandibular posterior implants were concurrently positioned in the appropriate CR position. Following the immediate establishment of a stable stop for proper CR, stable mastication in this position was achieved. The findings suggest that the patients with unstable CR guidance due to insufficient occlusal stabilization can attain immediate functional stability through a reliable teeth stop in the corrected CR position.
4.Dental Services of the International Summer Camp Event: Experiences from the 25th World Scout Jamboree, South Korea
Hayoung KIM ; Jaegon KIM ; Daewoo LEE ; Yeonmi YANG
Journal of Korean Academy of Pediatric Dentistry 2024;51(3):208-219
This study aims to analyze dental care at the 25th World Scout Jamboree (WSJ) using a predesigned standardized dental chart to provide a reference for the operation of dental emergency clinics at future large-scale youth events. The dental charts of all patients treated at the 25th WSJ emergency dental clinic were examined. Fisher’s exact tests were used to analyze the differences between youth scouts and adult leaders. Eighty visits of 71 patients were included in the study. The largest number of patients was from Asia-Pacific (49.3%), followed by patients from Europe (40.8%). In terms of chief complaints, oral ulcers (19.7%), lesions of the lips (18.3%), and orthodontic discomfort (15.5%) were the most prevalent. The analysis showed a significant difference (p = 0.0023) between youth scouts and adult leaders in the distribution of patients in the first half (July 30th - August 3rd) and second half (August 4th - August 8th) of the event. There was a higher incidence of dental conditions associated with hot and humid environments, unlike typical emergency dental settings. Therefore, despite adequate preparation, unexpected dental visits may occur, and it is recommended that operations be conducted in community-based dental hospitals to allow for immediate and efficient responses in international camps.
5.Analysis of Temporomandibular Joint Disorders in Children and Adolescents: Diagnosis and Treatment Pattern by Age
Heemin KIM ; Jaegon KIM ; Daewoo LEE ; Yeonmi YANG
Journal of Korean Academy of Pediatric Dentistry 2024;51(2):185-196
Temporomandibular joint disorders (TMDs) can occur at any age, including childhood and adolescence, and pain-related TMDs can affect growth and quality of life. In the present study, recent trends in the diagnosis and treatment of TMDs in children and adolescents were analyzed over a 10-year period. Using 10 years of data from the Health Insurance Review and Assessment Service (HIRA) and Jeonbuk National University (JBNU) Dental Hospital, patients between 0 and 19 years of age diagnosed with K07.6 (temporomandibular joint disorders) were analyzed by 5-year bins. Both datasets indicated a higher prevalence in females (1.2-fold in HIRA, 1.5-fold in JBNU) and in ages 15 to 19 years (72.1% in HIRA, 74.7% in JBNU). HIRA reported a 42.3% increase in prevalence per 100,000 people, from 651.4 in 2011 to 927.0 in 2020. JBNU reported K07.66 (masticatory muscle disorders) as the most common diagnosis in subjects under 10 years of age and K07.60 (internal derangement of temporomandibular joint) in those over 10 years of age. In addition, both were treated mainly by a combination of physical therapy and medication, and the treatment rate increased in accordance with age. Because TMDs can affect various structures in the orofacial region and cause pain that tends to differ with age, an early and specific diagnosis appropriate for age is important for treatment. Therefore, pediatric dentists need to promptly recognize TMDs in children and adolescents and consult with specialists as the prevalence increases.
6.Dental Services of the International Summer Camp Event: Experiences from the 25th World Scout Jamboree, South Korea
Hayoung KIM ; Jaegon KIM ; Daewoo LEE ; Yeonmi YANG
Journal of Korean Academy of Pediatric Dentistry 2024;51(3):208-219
This study aims to analyze dental care at the 25th World Scout Jamboree (WSJ) using a predesigned standardized dental chart to provide a reference for the operation of dental emergency clinics at future large-scale youth events. The dental charts of all patients treated at the 25th WSJ emergency dental clinic were examined. Fisher’s exact tests were used to analyze the differences between youth scouts and adult leaders. Eighty visits of 71 patients were included in the study. The largest number of patients was from Asia-Pacific (49.3%), followed by patients from Europe (40.8%). In terms of chief complaints, oral ulcers (19.7%), lesions of the lips (18.3%), and orthodontic discomfort (15.5%) were the most prevalent. The analysis showed a significant difference (p = 0.0023) between youth scouts and adult leaders in the distribution of patients in the first half (July 30th - August 3rd) and second half (August 4th - August 8th) of the event. There was a higher incidence of dental conditions associated with hot and humid environments, unlike typical emergency dental settings. Therefore, despite adequate preparation, unexpected dental visits may occur, and it is recommended that operations be conducted in community-based dental hospitals to allow for immediate and efficient responses in international camps.
7.Dental Services of the International Summer Camp Event: Experiences from the 25th World Scout Jamboree, South Korea
Hayoung KIM ; Jaegon KIM ; Daewoo LEE ; Yeonmi YANG
Journal of Korean Academy of Pediatric Dentistry 2024;51(3):208-219
This study aims to analyze dental care at the 25th World Scout Jamboree (WSJ) using a predesigned standardized dental chart to provide a reference for the operation of dental emergency clinics at future large-scale youth events. The dental charts of all patients treated at the 25th WSJ emergency dental clinic were examined. Fisher’s exact tests were used to analyze the differences between youth scouts and adult leaders. Eighty visits of 71 patients were included in the study. The largest number of patients was from Asia-Pacific (49.3%), followed by patients from Europe (40.8%). In terms of chief complaints, oral ulcers (19.7%), lesions of the lips (18.3%), and orthodontic discomfort (15.5%) were the most prevalent. The analysis showed a significant difference (p = 0.0023) between youth scouts and adult leaders in the distribution of patients in the first half (July 30th - August 3rd) and second half (August 4th - August 8th) of the event. There was a higher incidence of dental conditions associated with hot and humid environments, unlike typical emergency dental settings. Therefore, despite adequate preparation, unexpected dental visits may occur, and it is recommended that operations be conducted in community-based dental hospitals to allow for immediate and efficient responses in international camps.
8.National Patterns and Characteristics in Pediatric Dental Emergency Visits for Dental Conditions
Seongeun MO ; Myeongkwan JIH ; Jewoo LEE ; Jaegon KIM ; Yeonmi YANG ; Van Nhat Thang LE ; Daewoo LEE
Journal of Korean Academy of Pediatric Dentistry 2022;49(2):188-196
The purpose of this study was to investigate pediatric emergency department visits patterns and characteristics of children and adolescents under the age of 20 in South Korea from 2002 to 2015 due to dental conditions. This study used a stratified sample of approximately 1 million people from the Health Insurance Review and Assessment Service Database. The age, region, household income, and treatment cost were included for the patient characteristic analysis. Pediatric patients were compared to the adult group (over 20 years old).In children and adolescents, the rate of emergency department visits due to dental conditions was higher for traumatic conditions than for non-traumatic conditions. Children and adolescents with higher household income visited the emergency department more often than those with lower household income. The region with the highest number of children and adolescents visiting the emergency department for dental conditions was Busan (per 100,000 population).Although this study could not confirm the annual trend of children and adolescents’ dental emergency visits due to the sample size limitation, the characteristics of children and adolescents’ dental emergency visits were compared with those of adults using a stratified sample.
9.A Study on Factors Related to Sleep Disordered Breathing in Children
Nawoon KIM ; Daewoo LEE ; Jaegon KIM ; Changkeun LEE ; Yeonmi YANG
Journal of Korean Academy of Pediatric Dentistry 2022;49(2):180-187
The aim of this study was to investigate the risk factors associated with sleep disordered breathing (SDB) by comparing intraoral factors, body mass index (BMI), and medical history with pediatric sleep questionnaire (PSQ) findings.Seven hundred eighty-seven subjects aged between 7 to 11 years old were included. Their caregivers were asked to complete questionnaires. Oral manifestations including Angle’s classification, overjet, and Brodsky tonsil grade were examined. Children with PSQ scores of more than 0.33 points were classified into the SDB high-risk group.Among the 787 subjects, 34 (4.3%) were classified into the SDB high-risk group. Children with allergic rhinitis, atopic dermatitis, excessive overjet, or large tonsil size had a significantly higher risk for SDB versus those without. Also, there was a significant difference in SDB risk according to BMI status. Gender, gestational age, breastfeeding, and Angle’s classification were not associated with SDB.Children at high risk for SDB were predisposed to tonsillar hypertrophy, allergic rhinitis, obesity, and atopic dermatitis. Children with these factors could be candidates for early intervention to prevent the progression of SDB.
10.Diagnostic Impact of Clinical Manifestations of Group A Streptococcal Pharyngitis
Seon A JO ; Sang Hyuk MA ; Sunjoo KIM
Infection and Chemotherapy 2021;53(3):553-556
This study aims to identify the clinical characteristics for diagnosing streptococcal pharyngitis. The correlation between eighteen clinical manifestations and rapid antigen detection test results was analyzed. Among 205 patients, five clinical manifestations, pharyngeal hemorrhage (odds ratio [OR] = 11.85), palatal hemorrhage (OR = 9.32), tonsillar swelling (OR = 4.37), rash (OR = 3.02), and enlarged cervical nodes (OR = 1.91), were significantly correlated with group A Streptococcus (GAS) pharyngitis. Traditional indicators such as fever, pharyngeal redness, acute onset, headache, rhinorrhea, cough, tonsillar exudate, and cervical tenderness were not statistically related to GAS pharyngitis. Therefore, physicians should be cautious in using these traditional indicators

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