Recurrent scalp compromise following deep brain stimulation (DBS) implantation remains a challenging reconstructive problem, particularly in patients with chronic infection and repeated revision procedures. We present an acellular dermal matrix (ADM)-assisted salvage strategy using rotational scalp flap coverage with adjunctive calvarial recession for preservation of exposed DBS hardware. After debridement and subperiosteal flap elevation, ADM was applied over the exposed hardware as a biologic reinforcement layer prior to tension-free closure. Adjunctive calvarial recession was performed to reduce hardware prominence. Postoperative computed tomography demonstrated decreased hardware projection, and stable wound healing without recurrent dehiscence or infection was maintained during follow-up. This combined approach may represent an effective salvage option for recurrent DBS scalp compromise while preserving functional neuromodulation hardware.

This report presents the latest statistics on the stroke population in South Korea, sourced from the Clinical Research Collaborations for Stroke in Korea-National Institute for Health (CRCS-K-NIH), a comprehensive, nationwide, multicenter stroke registry. The Korean cohort, unlike western populations, shows a male-to-female ratio of 1.5, attributed to lower risk factors in Korean women. The average ages for men and women are 67 and 73 years, respectively.Hypertension is the most common risk factor (67%), consistent with global trends, but there is a higher prevalence of diabetes (35%) and smoking (21%). The prevalence of atrial fibrillation (19%) is lower than in western populations, suggesting effective prevention strategies in the general population. A high incidence of large artery atherosclerosis (38%) is observed, likely due to prevalent intracranial arterial disease in East Asians and advanced imaging techniques.There has been a decrease in intravenous thrombolysis rates, from 12% in 2017–2019 to 10% in 2021, with no improvements in door-to-needle and door-to-puncture times, worsened by the coronavirus disease 2019 pandemic. While the use of aspirin plus clopidogrel for noncardioembolic stroke and direct oral anticoagulants for atrial fibrillation is well-established, the application of direct oral anticoagulants for non-atrial fibrillation cardioembolic strokes in the acute phase requires further research. The incidence of early neurological deterioration (13%) and the cumulative incidence of recurrent stroke at 3 months (3%) align with global figures. Favorable outcomes at 3 months (63%) are comparable internationally, yet the lack of improvement in dependency at 3 months highlights the need for advancements in acute stroke care.

Accessory extensor pollicis longus tendons are rare tendon anomalies. This report describes the case of a 54-year-old man who presented with pain and difficulty extending his thumb. Upon initial examination, despite a history of trauma, he could extend the interphalangeal joint, but with limited range. During the surgical exploration, an accessory extensor pollicis longus tendon was unexpectedly discovered. This tendon ran parallel to the extensor pollicis longus on the radial side and then attached to the distal phalanx of the thumb. Accessory extensor tendons are more commonly found on the ulnar side than on the radial side of the hand; therefore, this case is notable due to the unusual location of the tendon. After appropriate repair surgery, the patient successfully regained a normal range of motion. While previous classifications of extensor tendon anomalies have focused on the relationship between the extensor indicis proprius and extensor digitorum communis, this case suggests that it is also necessary to consider the relationship with the extensor pollicis brevis tendon. This case highlights the importance of recognizing tendon variations, especially in trauma situations. Detecting such variations preoperatively using imaging can significantly impact the treatment plan and surgical approach.

Accessory extensor pollicis longus tendons are rare tendon anomalies. This report describes the case of a 54-year-old man who presented with pain and difficulty extending his thumb. Upon initial examination, despite a history of trauma, he could extend the interphalangeal joint, but with limited range. During the surgical exploration, an accessory extensor pollicis longus tendon was unexpectedly discovered. This tendon ran parallel to the extensor pollicis longus on the radial side and then attached to the distal phalanx of the thumb. Accessory extensor tendons are more commonly found on the ulnar side than on the radial side of the hand; therefore, this case is notable due to the unusual location of the tendon. After appropriate repair surgery, the patient successfully regained a normal range of motion. While previous classifications of extensor tendon anomalies have focused on the relationship between the extensor indicis proprius and extensor digitorum communis, this case suggests that it is also necessary to consider the relationship with the extensor pollicis brevis tendon. This case highlights the importance of recognizing tendon variations, especially in trauma situations. Detecting such variations preoperatively using imaging can significantly impact the treatment plan and surgical approach.

Accessory extensor pollicis longus tendons are rare tendon anomalies. This report describes the case of a 54-year-old man who presented with pain and difficulty extending his thumb. Upon initial examination, despite a history of trauma, he could extend the interphalangeal joint, but with limited range. During the surgical exploration, an accessory extensor pollicis longus tendon was unexpectedly discovered. This tendon ran parallel to the extensor pollicis longus on the radial side and then attached to the distal phalanx of the thumb. Accessory extensor tendons are more commonly found on the ulnar side than on the radial side of the hand; therefore, this case is notable due to the unusual location of the tendon. After appropriate repair surgery, the patient successfully regained a normal range of motion. While previous classifications of extensor tendon anomalies have focused on the relationship between the extensor indicis proprius and extensor digitorum communis, this case suggests that it is also necessary to consider the relationship with the extensor pollicis brevis tendon. This case highlights the importance of recognizing tendon variations, especially in trauma situations. Detecting such variations preoperatively using imaging can significantly impact the treatment plan and surgical approach.

Background: The purpose of this study was to evaluate the effect of vanishing twin (VT) on maternal serum marker concentrations and nuchal translucency (NT). Methods: This is a secondary analysis of a multicenter prospective cohort study in 12 institutions. Serum concentrations of pregnancy-associated plasma protein-A in the first trimester and alpha-fetoprotein (AFP), total human chorionic gonadotrophin, unconjugated estriol, and inhibin A in the second trimester were measured, and NT was measured between 10 and 14 weeks of gestation. Results: Among 6,793 pregnant women, 5,381 women were measured for serum markers in the first or second trimester, including 65 cases in the VT group and 5,316 cases in the normal singleton group. The cases in the VT group had a higher median multiple of the median value of AFP and inhibin A than the normal singleton group. The values of other serum markers and NT were not different between the two groups. After the permutation test with adjustment,AFP and inhibin A remained significant differences. The frequency of abnormally increased AFP was also higher in the VT group than in the normal singleton group. Conclusion VT can be considered as an adjustment factor for risk assessment in the secondtrimester serum screening test.

BACKGROUND: Beating cardiomyocyte regeneration therapies have revealed as alternative therapeutics for heart transplantation. Nonetheless, the importance of nitric oxide (NO) in cardiomyocyte regeneration has been widely suggested, little has been reported concerning endogenous NO during cardiomyocyte differentiation. METHODS: Here, we used P19CL6 cells and a Myocardiac infarction (MI) model to confirm NO-induced protein modification and its role in cardiac beating. Two tyrosine (Tyr) residues of b2-tubulin (Y106 and Y340) underwent nitrosylation (Tyr-NO) by endogenously generated NO during cardiomyocyte differentiation from pre-cardiomyocyte-like P19CL6 cells. RESULTS: Tyr-NO-b2-tubulin mediated the interaction with Stathmin, which promotes microtubule disassembly, and was prominently observed in spontaneously beating cell clusters and mouse embryonic heart (E11.5d). In myocardial infarction mice, Tyr-NO-b2-tubulin in transplanted cells was closely related with cardiac troponin-T expression with their functional recovery, reduced infarct size and thickened left ventricular wall. CONCLUSION This is the first discovery of a new target molecule of NO, b2-tubulin, that can promote normal cardiac beating and cardiomyocyte regeneration. Taken together, we suggest therapeutic potential of Tyr-NO-b2-tubulin, for ischemic cardiomyocyte, which can reduce unexpected side effect of stem cell transplantation, arrhythmogenesis.

Little is known about how the interaction between red blood cell distribution width (RDW) and vascular calcification (VC) affects cardiovascular (CV) events and mortality in end-stage kidney disease (ESKD) patients. This study investigated the combined prognostic effect of RDW and VC in ESKD patients starting dialysis. Methods: A retrospective single-center study of 582 ESKD patients was conducted. VC was assessed by calculating the aortic calcification index (ACI) using computed tomography. Patients were divided into low ACI-low RDW, low ACI-high RDW, high ACI-low RDW, and high ACI-high RDW groups based on median ACI (17.12) and RDW (14.3) values. The association between RDW and VC and the composite endpoint of CV events and death was analyzed. Results: During a median follow-up of 3.1 years (range, 1.5–5.5 years), 165 CV events (28.4%) and 124 deaths (21.4%) occurred. Cox regression showed that the low ACI-high RDW (adjusted hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.04–2.66; p = 0.03) and high ACI-low RDW (adjusted HR, 1.95; 95% CI, 1.21–3.14; p = 0.006) groups had a greater risk of CV events and death than the low ACI-low RDW group. The high ACI-high RDW group had the greatest risk (adjusted HR, 2.23; 95% CI, 1.42–3.52; p = 0.001). The effect of the interaction between ACI and RDW on CV events and mortality was statistically significant (p = 0.005). Conclusion: High RDW and VC interact to increase the risk of CV events and death in ESKD patients.