Objective:To review the research status, international cooperation, hot topics and development trends of frailty intervention based on the perspective of scientometrics, so as to provide references for the development of relevant intervention research in this field.Methods:The studies on frailty intervention included in Web of Science Citation Database was retrieved, and the retrieval period was from the establishment of the databases to December 31, 2021. Bibliometric analysis was conducted using VOSviewer and R-bibliometrix.Results:From 1992 to 2021, the overall number of literature on intervention studies on senile frailty worldwide showed an increasing trend year by year, and a relatively stable network of cooperative relationships between countries and regions has been formed internationally. The intervention mode for frailty was mainly based on nutrition combined with exercise intervention, and intervention research on frailty was gradually being carried out in the field of chronic diseases.Conclusions:Frailty intervention will be the focus of future research, nutrition combined with exercise and cognitive intervention mode will be the main research trend of future research, and more frailty intervention studies will be carried out in the elderly population with chronic diseases.

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic autoimmune disease affecting the peripheral nervous system mediated by cellular and humoral immunity, characterized by limb weakness and sensory impairment. The main feature of CIDP by electrophysiological and pathological examinations is the demyelination of peripheral nerves. First-line treatment for CIDP includes glucocorticoids, intravenous immunoglobulins, and plasmapheresis. Some patients respond to current treatment not well and have a poor prognosis. Progress in the pathogenesis, diagnosis, and treatment of CIDP worldwide was reviewed in this article, aiming to provide references for the clinical diagnosis and treatment of CIDP.

Objective To observe the effects of ultrasound-guided modified obturator nerve block(ONB)combined with remazolam anesthesia on obturator nerve reflex(ONR)and postoperative recovery of patients with transurethral resection of bladder tumors(TURBT).Methods One hundred patients with bladder tumor admitted to Qinhuangd-ao Hospital from June 2019 to June 2021 were treated with TURBT.They were divided into conventional group(in-traspinal anesthesia+traditional ONB anesthesia)and ultrasound group(intraspinal anesthesia+improved ONB combined with remidazolam anesthesia under ultrasound guidance)with 50 cases in each according to different ONB methods.Perioperative indexes,hemodynamic indexes at different time points,intraoperative ONR occur-rence,complications and adverse anesthesia reactions were compared between the two groups.Results Compared with conventional group,ONB time,operation time,catheter indwelling time and hospital stay were shortened,and intraoperative blood loss was decreased in ultrasound group(P＜0.05).Compared with the conventional group at 30 min after administration(T1)and at the end of operation(T2),the mean arterial pressure(MAP)and oxygen saturation(SaO2)were increased in the ultrasound group(P＜0.05).Compared with the convention-al group,the incidence of ONR and bladder bleeding was decreased,and the incidence of postoperative bradycar-dia,nausea and vomiting were decreased in the ultrasound group(P＜0.05).Conclusions Ultrasound-guided modified ONB combined with remazolam anesthesia can effectively improve perioperative indexes of TURBT,re-duce intraoperative ONR and bladder bleeding,and have little influence on hemodynamics with few postoperative adverse anesthesia reactions.

Obesity is a recognized risk factor for stroke. However, many studies have shown that compared with normal weight and underweight patients, obese or overweight patients with ischemic stroke have lower risk of death and better functional outcome, suggesting that there is an obesity paradox in patients with ischemic stroke. In contrast, the obesity paradox was not observed in patients receiving reperfusion therapy, including intravenous thrombolysis and endovascular therapy. Therefore, whether there is obesity paradox in ischemic stroke is still controversial. Further high-quality evidence is needed to clarify the correlation between body weight and the outcome of ischemic stroke.

Objective:To summarizes the evidence of oral and nasal care for adult inpatients during nasal tube feeding and provide reference for clinical implementation.Methods:The relevant evidence on oral and nasal care of adult patients with nasal feeding were systematically searched on UpToDate, Joanna Briggs Institute (JBI) Evidence-based Healthcare Center, National Guideline Clearinghouse, National Institute for Health and Clinical Excellence, Medlive.cn, Cochrane Library, PubMed, Embase, Web of Science, China National Knowledge Infrastructure, Wanfang database and other databases and guideline websites. The retrieval period was from January 1, 2016 to August 28, 2020. After the methodological quality evaluation of the included clinical practice guidelines, expert consensus, systematic evaluation, clinical decision-making and evidence summary, the literature that met the standards was extracted and the evidence was summarized according to the professional clinical judgment of the researchers.Results:A total of 13 literatures were included, including 1 guideline, 2 expert consensus, 3 systematic evaluation, 2 clinical decision making and 5 evidence summaries. After sorting out, 16 best evidences were summarized from 4 aspects such as professional training of nursing staff, factors affecting oral and nasal hygiene, assessment and nursing of nasal, assessment and nursing of oral.Conclusions:Through the standardized evidence collection and formulation method, this paper summarizes the relevant evidence of oral and nasal nursing for patients with enteral nutrition through nasal tube feeding from 4 aspects. Medical staff should strengthen the training of professionals, find out the factors affecting the oral and nasal health of adult inpatients undergoing nasal tube feeding as soon as possible and take effective measures to evaluate and care the patients' oral and nasal cavity according to the best evidence.

Intra-abdominal hypertension can reduce the perfusion of the mesenteric artery, block venous return and reduce gastrointestinal function due to intestinal edema. And the delay of intestinal emptying can easily cause intestinal edema, which further increases intra-abdominal pressure and forms a vicious circle. Nutritional support plays an important role in treatment of severe patients with abdominal hypertension, as people have a deeper understanding of the importance of central organ of the intestinal stress response and the function of the intestinal barrier. This paper summarizes the implementation of enteral nutrition management for severe patients with abdominal hypertension, implements the standardized process of enteral nutrition implementation, evaluates nutritional risks, calculates target calorie intake and dynamically monitors intra-abdominal pressure, so as to ensure safety and effectiveness of patients in the process of nutritional support and to improve nutritional indexes and prognosis.

Objective? To explore the effect of health education based on health belief model (HBM) on the adherence to regular postoperative follow-up of patients with intracranial aneurysms (ICA) after surgery in rural areas. Methods? A mixed research method was adopted in the study. In the first phase, purposive sampling method was used when conducting qualitative interviews in order to analyze the reasons for the in-adherence in the target population. In the second phase, non-synchronous controlled trial was carried out and 312 patients from rural areas who underwent ICA invasive surgery in Ji＇ning No.1 People＇s Hospital from June 2015 to December 2016 were selected and put into control group. Routine health education was adopted for the group. A total of 268 patients who underwent ICA invasive surgery in The First People＇s Hospital of Ji'ning City from April 2017 to June 2018 were selected and assigned into the observation group. Based on the results from the qualitative interview, the HBM health education was applied in the observation group. The two groups were analyzed and compared in terms of their adherence to regular revisit after discharge. Results? A total of 4 themes were extracted during the qualitative research phase: there is insufficient understanding of the possibility and harm of recurrence after ICA intervention, insufficient understanding of the necessity of angiographic review, concerns about hospitalization and hospitalization expenses for angiographic review, poor health care awareness and lack of attention to disease prevention. After implementing the intervention, the adherence to timely postoperative follow-up in the observation group (95.52%) was higher than that of the control group (62.82%)with statistical significance (χ2=89.64,P＜ 0.01). Conclusions? Health education based on HBM can improve the adherence to regular postoperative review among rural patients with intracranial aneurysms. Health belief model should be applied as guidance into clinical health education.

The new media communication mode is characterized by personalization, instantization, liberalization, virus transmission and interactiveness. Changes in the way of new media communication have led to changes in hospital reputation in terms of improving effect, formation mode, maintenance approach, and hospital-public relations. At the same time, there are also serious crisis of trust, weak management, crisis at any time and severe lemon effect. Give full play to the advantages of new media and improve the comprehensive strength of hospital reputation;In the new media as the carrier, building reputation management chain, strengthening the relationship between stakeholder management, strengthening the management of hospital reputation promotion, new media public opinion monitoring and establishing dynamic hospital reputation crisis management mechanism will likely become the optimizing strategy to make up the above deficiencies and the chief way for the hospital culture construction and promotion in the future.

Objective To compare the flow cytometry versus test tube method in detecting antibody titer in ABO blood type,and try to establish a standard method using flow cytometry to provide insight in ABO incompatible kidney transplantation and therapeutics.Methods The ABO blood type titers of anti-IgM-A/B and anti-IgG-A/B in 30 serum samples from renal allograft recipients were measured by flow cytometry.The results were compared with those determined by test tube method.Results The titers by cytometry significantly higher than those by test tube method (P＜0.05).Conclusion The sensitivity of flow cytometry is significantly higher than test tube method,and flow cytometry can precisely monitor the ABO blood titers in renal allograft recipients,which can provide better medical advice in clinical treatment and therapeutics.

Objective:To explore the effects of caffeine on the prevention of Alzheimer's disease (AD).Methods:Use Ethanol as a solvent to extract the caffeine in tea and then injecting 5％ D-galactose saline solution 1ml/d/kg to establish aging model mice.Divide mice randomly into experimental group (high-dose/low-dosecaffeine),positive control group,negative control group,and normal con-trol group (NS) and injecting appropriate drugs for consecutive four weeks.Test superoxyde dismutase (SOD) and malondialdehvde (MDA) periodically.Take mice's hippocampus and use Western blotting to detect the expression of brain derived neurotrophic factor (BDNF) and extracellular signal-regulated kinasesl/2 (p-ERK1/2).Results:The expression of BDNF and p-ERK1/2,negative control group is less than low-dose experimental group and positive control group (P＜0.01);The p-ERK1/2 expression of injecting D-galactose mice was significantly lower than normal group,negative control group compared weth the normal group,the differencd was significant (P＜0.05).The level of SOD in model group was significantly lower than that in normal control group,high,low dose caffeine group and positive control group (P＜0.01),but the level of MDA is opposite.Conclusions:Caffeine can delay aging process by increasing the level of SOD in aging mice,and enhancing the expression of BDNF and P-ERK1/2.Caffeine does a lot to prevent AD.