Objective To analyze the influencing factors of diabetic cardiovascular autonomic neuropathy(DCAN)secondary to type 2 diabetes mellitus(T2DM).Methods A total of 63 T2DM patients admitted to Department of Endocrinology in our hospital from Nov.1,2022 to Nov.30,2023 were enrolled.All patients were examined by cardiovascular autonomic nervous system.According to the results,they were assigned to DCAN group or non-DCAN group.Baseline data and laboratory parameters were recorded for each group.Logistic regression analysis was used to identify the influencing factors of DCAN secondary to T2DM,and receiver operating characteristic(ROC)curve analysis was used to study the predictive value of the influencing factors on DCAN.Results There were 32(50.79％)patients in the DCAN group and 31(49.21％)patients in the non-DCAN group.The mean age of the patients was significantly older in the DCAN group than in the non-DCAN group(P=0.002).Logistic regression analysis showed that age was a risk factor for DCAN secondary to T2DM(odds ratio=1.095,95％confidence interval 1.029-1.166,P=0.04).The ROC curve showed that the area under curve value of age predicting DCAN was 0.718,and the best diagnostic value was 58.5 years old,with a sensitivity of 0.719 and a specificity of 0.645.Conclusion Age is a risk factor for DCAN secondary to T2DM,and an increase in age leads to a higher positive rate of DCAN.

The complement system is an important part of the innate immune system,including more than 50 secretory proteins and membrane-bound proteins,and it contributes to the clearance of apoptotic cells and invading pathogens to limit inflammatory immune responses and maintaining brain homeostasis.Complement activity is strictly regulated to protect cells from random attacks or to prevent the deposition of complement proteins in physiological cases.However,overactivation or abnormal regulation of the complement cascade in the brain can lead to neuronal damage and brain dysfunction.Recent studies have pointed out that changes in complement molecules exist in patients with psychiatric diseases and play an important role in the occurrence and development of diseases by regulating the function of neurons and glial cells.Therefore,summarizing the latest research progress of complement system in psychiatric diseases such as schizophrenia,autism spectrum disorder,major depression,bipolar disorder and anxiety disorder can provide new ideas for preventing and controlling psychiatric diseases caused by abnormal activation of complement system.