Objective To analyze the distribution characteristics of the single nucleotide polymorphism (SNP) site rs76206423 in the promoter region of the interleukin-2 receptor (IL-2R) β gene among Han males in a high radiation background area (HBRA) in Yangjiang City. Methods A total of 48 male participants from Tangkou Town, Yangxi County, Yangjiang City (HBRA group), and 51 male participants from Hengpo Town, Enping City (control group) were selected as the research subjects using the random number table method. Peripheral venous blood samples of participants from both groups were collected, and genomic DNA was extracted. The genotyping and allele frequency distribution of the rs76206423 (A/G) site in the IL-2R β promoter region was detected among the participants in both groups using the SNP detection method. The difference of allele frequencies between population in HBRA group and five area of East Asia, South Asia, Africa, Europe, and the Americas published in the Human Genome Project database from National Center for Biotechnology Information were analyzed. Results The allele frequencies of rs76206423 of population in both groups conformed to Hardy-Weinberg equilibrium (P>0.05). In the HBRA group, the AA genotype was predominant (64.6%), while the AG genotype was the most common in the control group (51.0%), with a significant difference (P<0.05). Population in both groups showed a predominance of the variant allele A (78.1% and 72.5%, respectively), with no significant difference (P>0.05). The frequency of the G allele of rs76206423 in the population in HBRA group was higher than those in South Asian, African, European, and American populations (all P<0.01), but showed no significant difference compared with East Asian populations (P>0.05). Conclusion In the Han male population from the HBRA in Yangjiang City, the rs76206423 site in the IL-2R β gene promoter region is predominantly composed of the wild-type A allele and AA genotype, indicating genetic stability and a relatively high degree of variation at this locus.

Objective To explore the application value of distortion product otoacoustic emission (DPOAE) and speech in noise(SIN) testing in occupational health surveillance of noise-exposed workers. Methods A total of 220 noise-exposed workers was selected as the study subjects using the convenient sampling method. The study subjects participated questionnaire survey, personal noise exposure assessment, acoustic immittance testing, pure tone audiometry (PTA), DPOAE and SIN testing. According to PTA results, workers were enrolled into a high-frequency hearing loss (HFHL) group and a non-HFHL group. Results The detection rate of HFHL among the study subjects was 41.4%, and the detection rate of speech-frequency hearing loss was 15.9%. Workers′ bilateral DPOAE response amplitudes and signal-to-noise ratios at frequencies of 2.0-8.0 kHz in the HFHL group were lower than those in the non-HFHL group (all P<0.05). The DPOAE amplitudes at frequencies of 1.0-8.0 kHz in both ears of the study subjects were negatively correlated with the PTA threshold (all P<0.01), and were negatively correlated with age (all P<0.01). The signal-to-noise ratio loss score was higher among worker in the HFHL group than in the non-HFHL group (P<0.01) and was positively correlated with PTA thresholds (P<0.05). Conclusion DPOAE and SIN testing can detect early cochlear outer hair cell impairment and reduction of noise-related speech recognition ability in noise-exposed workers and may serve as an effective supplementary tool to routine PTA in occupational hearing surveillance.

Objective:To investigate the symptom clusters and influencing factors among breast cancer patients receiving aromatase inhibitor treatment and to provide a theoretical basis for the symptom clusters management.Methods:From April 2020 to January 2021, 253 breast cancer patients were recruited in Peking University Cancer Hospital by convenient sampling method. All the patients were cross-sectional investigated by the demographic and clinical characteristics questionnaire, the M.D. Anderson Symptom Inventory, the Hospital Anxiety and Depression Scale. The principal component analysis was used to extract the symptom clusters and the multiple linear regression was used to analyze the risk factors.Results:During the period of breast cancer patients receiving aromatase inhibitor treatment, three symptom clusters were identified: sick symptom cluster, treatment related-psychological symptom cluster, digestive symptoms cluster. The prevalence of the three symptom clusters was 49.4%(125/253), 45.1%(114/253), 22.5%(57/253), respectively. The median severity of the three symptom clusters was 2.80, 2.00, 0.67, respectively. Multiple linear regression analysis showed that anxiety and education level were the influencing factors of sick symptom cluster ( β=0.25, -0.25, all P<0.05), anxiety, depression and educational level were the influencing factors of treatment related-psychological symptom cluster ( β = 0.34, 0.20, -0.16, all P<0.05), anxiety, depression and chemotherapy history were the influencing factors of digestive symptom cluster ( β= 0.17, 0.18, -0.13, all P<0.05). Conclusions:Breast cancer patients with aromatase inhibitor treatment are affected by symptom clusters. In order to relieve the symptom clusters, we need pay attention to the mentation, the education level and prerious treatment of the patients.

Breast cancer-related lymphedema is incurable once it occurs. The management of lymphedema is a long-term and continuous process, in which self-management plays an important role. This article reviews the research on self-management of lymphedema from three aspects: prevention, subclinical stage and maintenance stage. It aims to provide reference for effective self-management of breast cancer-related lymphedema in clinic.

Objective:To investigate the effect of long-term low dose ionizing radiation on the levels of interleukin (IL) and TGF-β1 in the population in high background radiation area(HBRA).Methods:Appropriate amount of peripheral blood was drawn from 41 and 44 healthy men aged 45-65 years who were randomly selected from Tangkou town of Yangjiang city (HBRA) and Hengpo town of Enping city (control area, CA), respectively. After centrifugation and stratification, the upper plasma of blood was separated to determine IL-2, sIL-2R, IL-4, IL-5 and TGF-β1 by using ELISA. The difference of plasma IL of the residents in those two regions was analyzed. The influence of region, age, smoking, drinking and income on the indexes of ILs and TGF-β1 was evaluated by Covariance analysis.Results:The concentration of IL-2 at HBRA area was slightly higher than those in the control area, but the other indexes were lower than those in CA residents. The differences of IL-5 ( t=7.124, P<0.001) and TGF-β1 ( t=4.900, P<0.001) between two areas were significant statistically. Covariance analysis showed that smoking had a significant effect on IL-2 level ( F=5.283, P<0.05). Conclusions:Under the influence of long-term low-dose ionizing radiation, all kinds of plasma interleukin levels of residents in HBRA were different with that in CA. The immune balance was biased towards Th1 type cytokines, and the immune function in HBRA was slightly stronger than that in CA, suggesting that long-term chronic low-dose ionizing radiation may induce adaptive changes in the immune function, which needs further study.

Objective: This study was aimed to analyze the epidemic trend and predict the incidence trend of occupational diseases during 2006-2015 in Guangdong province, which may provide the theoretical foundation for occupational disease risk assessment and precise control and prevention. Methods: We analyzed the number of reported occupational disease cases, the constituent ratio, the average age and working-age of patients. We also performed the linear-by-linear association test of new incidence, median age and median working-age by curve-fitting method, of which the diagnostic year was set as the independent variable. Meanwhile, we designed an ARIMA model to predict the variation tendency of occupational diseases in 2017-2020. Results: (1) During 2006-2015, the total reported cases of occupational disease is 5289, including 2101 cases of occupational pneumoconiosis (39.7%) , 1363 cases of occupational poisoning (25.8%) , and 864 cases of occupational otolaryngological and stomatological disease (16.3%) . (2) The number of occupational diseases and pneumoconiosis have a straight upward trend (R²=0.851, R²=0.856) , while the number of occupational otolaryngological and stomatological disease and occupational tumor have a exponential trend (R²=0.914, R²=0.696) . The constituent ratio of occupational poisoning is decreasing, and the constituent ratio of occupational otolaryngological and stomatological disease is increasing. (3) The average onset age is 40 (33, 46) years old, and the average onset working-age is 6 (3, 11) years. Both of them have a straight upward trend (R²=0.954、R²=0.792) . The onset age of pneumoconiosis, occupational poisoning and occupational otolaryngological and stomatological disease have a upward trend. In addition, the onset working-age of occupational poisoning and pneumoconiosis have a upward trend. (4) The number of occupational diseases in 2017-2020 is predicted to be between 902-1231. Conclusion Occupational diseases in Guangdong province showed a trend of high incidence. The age and working-age of occupational diseases showed an extended trend. Therefore, our work of occupational epidemic trend may provide some bases for the occupational disease risk assessment and precise control and prevention.

OBJECTIVE: To analyze the characteristics of newly diagnosed pneumoconiosis in gem processing industries in Guangdong Province from 2006 to 2016.METHODS: Data from Direct Reporting System for Occupational Disease Network in the gem processing industries in Guangdong Province from 2006 to 2016 were collected and analyzed according to pneumoconiosis disease category, regions, industry and enterprise characteristics.RESULTS: There were 202 new diagnosed pneumoconiosis cases in gem processing industry in Guangdong Province from 2006 to 2016,which showed a general decline trend after peaking in 2008.Among 202 cases,192 cases( 95.0%) were silicosis,9 cases( 4.5%) were other pneumoconiosis,1 case( 0.5%) was welder pneumoconiosis; 143 cases( 70.8%) were stage Ⅰ pneumoconiosis,44 cases( 21.8%) were stage Ⅱ pneumoconiosis,15 cases( 7.4%) were stage Ⅲ pneumoconiosis; 196 cases( 97.0%)were male and 6 cases( 3.0%) were female.The mean age for diagnosis was( 36.3 ± 0.4) years,and the median dust exposure duration was 9.6 years.There was 86.1% of cases centered at the Pearl River Delta region and 94.6% of cases working in jewelry and related goods manufacture industry,which were more commonly from Hong Kong,Macao,Taiwan and private own economy enterprises( 94.1%),as well as large and small enterprises( 72.2%).There was 38.2%( 21/55) of the enterprises reporting 2 or more cases,of which 3 enterprises had more than 10 new cases.The job titles of these cases were mainly drilling,cutting,sculpturing and stone cutting.CONCLUSION: The prevalence of pneumoconiosis in gem processing industries in Guangdong showed a decreasing tendency, but there is a potential risk of group onset of pneumoconiosis.The prevention and control procedures for dust hazard should be strengthened in gem processing industries.

OBJECTIVE: To analyze the epidemiological characteristics of occupational noise-induced deafness( ONID) in Guangdong Province from 2011 to 2015. METHODS: The data of ONID patients reported from National Information Surveillance System for Occupational Disease and Occupational Health during 2011 to 2015 in Guangdong Province were collected and retrospectively analyzed. RESULTS: From 2011 to 2015,739 patients with ONID were reported in Guangdong Province with a rapid rising trend. The average annual growth rate was 39. 57%. The majority( 88. 63%) of patients were males. The median age of onset of the disease was 39. 0 years old. The median length of noise exposure of the patients was 8. 0 years. A total of 82. 54% of the patients came from Shenzhen,Foshan,Guangzhou and Dongguan in Pearl River Delta area. Totally 92. 42% of the patients concentrate in the manufacturing industry. A total of 454 enterprises have reported cases,89. 85% of which were non-public type. There were 2-20 cases in 125 enterprises within 5 years. CONCLUSION: The reported cases of ONID showed a straight upward trend year by year in Guangdong Province,with clustering and grouponset characteristics. Therefore,prevention emphasis must be put on key districts,key industries,key enterprises,and key populations of ONID.

Objective To investigate arthralgia and quality of life among breast cancer survivors receiving third-generation aromatase inhibitors ( AIs ) . Methods With a cross-sectional study adopted, 204 breast cancer survivors receiving third-generation AIs treatment from the time range between March 2014 to December 2015 in Breast Cancer Prevention and Treatment Center, Beijing Cancer Hospital, were surveyed by general data questionnaire, Numerical rating scale ( NRS ) and Medical outcomes study 36-item short-form health survey ( SF-36 ) , about their arthralgia condition and quality of life. Results Totals of 154 cases ( 75. 5%) of the patients reported arthralgia. The numbers of patients with low level pain, moderate level pain, and severe level pain were 45(29.2%), 66 (42.9%), and 43 (27.9%). Scores of dimensions in SF-36 of patients in the arthralgia group were:role-physical (17.21±34.60) points, bodily pain (42.54±17.79), general health (46.79±23.94), and mental health (56.10±21.98), all lower than those of patients without arthralgia (t=3. 309,22. 777, 3. 077, 4. 981;P<0. 01). Conclusions Incidence of arthralgia in breast cancer survivors receiving third-generation aromatase inhibitors is high and it lowers patients′quality of life severely.

Objective To systematically evaluate the effects of the different postoperative exercise programs on the rehabilitation (such as shoulder range of motion,the incidence of the lymphedema and postoperative complications) of breast cancer patients.Methods The relevant randomized controlled trials which were retrieved from January 2008 to October 2013 were searched in the databases of the Pubmed,Embase,Ovid,Cochrane Library,China Biomedical Literature Database (CBM),China National Knowledge Infrastructure (CNKI),Wanfang Data,VIP.Two reviewers independently screened the literature according to the inclusive and exclusive criteria,extracted the data,and assessed the quality.The RevMan 5.2 software was used for Meta-analysis.Results Finally 10 randomized controlled trial involving 1 110 patients were included.The Metaanalysis showed that progressive exercise program compared to usual exercise obviously modified the shoulder anteflexion [MD =33.04 (26.85-39.23) and 28.05 (21.81-34.30)],abduction [MD =31.06 (8.17-53.95) and 31.39(24.96-37.82)],extorsion [MD=18.47(13.44-23.50) and 16.02(8.35-23.68)] 1 month and 3 months after surgery (P＜ 0.05),extension 1 month after surgery,adduction 3 months after surgery.It also decreased the incidence of the lymphedema.Conclusions It gives us some evidence that the progressive exercise program can promote the rehabilitation of the postoperative breast cancer patients.