Objective:To investigate the incidence and risk factors associated with poor healing in closed drainage incisions among elderly lung cancer patients(aged ≥65 years)undergoing thoracoscopic pulmonary resection.Methods:A retrospective cohort study was conducted involving 471 elderly lung cancer patients who underwent single utility port video-assisted thoracic surgery(VATS)pulmonary resection at Beijing Hospital from January 1, 2022, to December 31, 2023.Patients were categorized into'healed’and'poor healing’groups based on the development of grade B/C healing following the removal of the closed drainage tube.A comparative analysis of demographic characteristics, medical history, and perioperative parameters between the groups was performed.Multivariate logistic regression analysis was employed to identify independent risk factors for poor incision healing.Results:A total of 471 elderly lung cancer patients who underwent VATS lobectomy were enrolled, with a mean age of 71.16 ± 3.44 years. Among them, 200(42.46%)were male and 271(57.54%)were female.Among 471 patients, 101(21.44%)developed poor healing, all classified as grade B. Univariate analysis revealed statistically significant differences between the two groups regarding BMI( χ2=1.632, P=0.004), diabetes mellitus( χ2=1.558, P=0.004), prolonged drainage duration ( χ2=1.829, P=0.002), and the extent of pulmonary resection( χ2=2.571, P=0.042).Multivariate logistic regression analysis indicated that a BMI of ≥24 kg/m 2( OR=1.534, 95% CI: 1.191-3.289, P=0.033), drainage tube indwelling time exceeding 4 days postoperatively( OR=1.712, 95% CI: 1.014-3.791, P=0.036), and diabetes mellitus( OR=1.855, 95% CI: 1.418-4.015, P=0.002)were significant factors influencing poor wound healing, with statistically significant differences noted( P<0.05). Conclusions:BMI, prolonged drainage duration, diabetes mellitus, and the extent of pulmonary resection are independent risk factors for poor healing of closed drainage incisions in elderly lung cancer patients following VATS.Clinical strategies should prioritize the control of BMI, perioperative glycemic management, real-time monitoring of drainage, and timely removal of tubes to mitigate complications.

Objective:To investigate the incidence and risk factors associated with poor healing in closed drainage incisions among elderly lung cancer patients(aged ≥65 years)undergoing thoracoscopic pulmonary resection.Methods:A retrospective cohort study was conducted involving 471 elderly lung cancer patients who underwent single utility port video-assisted thoracic surgery(VATS)pulmonary resection at Beijing Hospital from January 1, 2022, to December 31, 2023.Patients were categorized into'healed’and'poor healing’groups based on the development of grade B/C healing following the removal of the closed drainage tube.A comparative analysis of demographic characteristics, medical history, and perioperative parameters between the groups was performed.Multivariate logistic regression analysis was employed to identify independent risk factors for poor incision healing.Results:A total of 471 elderly lung cancer patients who underwent VATS lobectomy were enrolled, with a mean age of 71.16 ± 3.44 years. Among them, 200(42.46%)were male and 271(57.54%)were female.Among 471 patients, 101(21.44%)developed poor healing, all classified as grade B. Univariate analysis revealed statistically significant differences between the two groups regarding BMI( χ2=1.632, P=0.004), diabetes mellitus( χ2=1.558, P=0.004), prolonged drainage duration ( χ2=1.829, P=0.002), and the extent of pulmonary resection( χ2=2.571, P=0.042).Multivariate logistic regression analysis indicated that a BMI of ≥24 kg/m 2( OR=1.534, 95% CI: 1.191-3.289, P=0.033), drainage tube indwelling time exceeding 4 days postoperatively( OR=1.712, 95% CI: 1.014-3.791, P=0.036), and diabetes mellitus( OR=1.855, 95% CI: 1.418-4.015, P=0.002)were significant factors influencing poor wound healing, with statistically significant differences noted( P<0.05). Conclusions:BMI, prolonged drainage duration, diabetes mellitus, and the extent of pulmonary resection are independent risk factors for poor healing of closed drainage incisions in elderly lung cancer patients following VATS.Clinical strategies should prioritize the control of BMI, perioperative glycemic management, real-time monitoring of drainage, and timely removal of tubes to mitigate complications.

Objective To explore the effect of robot-assisted gait training on pelvis kinematics and the walking function of hemiplegic stroke survivors.Methods Thirty stroke survivors with hemiplegia were randomly divided into a treatment group and a control group,each of 15.Both groups were given routine clinical medication and rehabilitation training,while the treatment group was additionally provided with 20 minutes of robot-assisted gait training a day,6 d/wk for 8 weeks.Before and after the treatment,all of the patients' pelvis kinematics were assessed using 10 m walking speed (MWS),the timed up and go test (TUGT) and functional ambulation categorization (FAC).Results Before the treatment there were no significant differences between the two group in any of the measurements.After the treatment,significant improvement was observed in both groups in the vertical displacement and rotation and tilt angles of the pelvis while walking,with significantly more improvement in the treatment group than in the control group.There was also significant improvement in the average walking speed,TUGT time and FAC score of both groups,with significantly more improvement in the treatment group.Conclusion Robot-assisted gait training can significantly improve the pelvis control and walking ability of hemiplegic stroke survivors.

Objective To explore the safety of salbutamol and doxofylline treatments with different orders.Methods The subjects were inpatients who need to be treated with salbutamol and doxofylline in Department of Respiratory and Critical Care Medicine Ward,Beijing Hospital during September 2012 to December 2014.Firstly,the nurses were divided into A,B,and C groups and the admitted patients in accordance with inclusion criteria were entered into the on-duty nurses' group.The patients in the group A received intravenous injection of doxofylline after salbutamol inhalation,the patients in the group B received salbutamol inhalation and intravenous injection of doxofylline at the same time,and the patients in the group C received salbutamol inhalation after intravenous injection of doxofylline (a total of 1 to 2 treatment cycles,the treatment was stopped if adverse reactions occurred).The adverse reactions in the 3 groups were observed.Results Each group comprised 100 patients.There were 63 males in the group A and average age was (71 ±13) years;58 males in the group B and average age was (71 ± 12) years;64 males in the group C and average age was (73 ± 12) years.The diseases in patients in the 3 groups included chronic obstructive pulmonary disease,pneumonia,lung cancer,lung infection,bronchiectasis,and bronchial asthma,etc.The differences of age,gender distribution,and percentages of different diseases among the three groups were not statistically significant (all P ＞ 0.05).Totally 24 cases of adverse reactions appeared in 16 patients in the 3 groups,including 12 cases of palpitations,10 cases of shortness of breath,and 1 case of finger tremor.The incidence of adverse reactions in the 3 groups were 2％ (2/100),10％ (10/100),and 5％ (5/100),respectively.The difference between the group A and the group B was statistically significant (P =0.045).Conclusions Salbutamol inhalation and intravenous injection of doxofylline with different order had an marked impact on medication safety.The incidence of adverse reactions was the lowest when the patients were given intravenous injection of doxofylline after salbutamol inhalation.

Objective To explore the safety of salbutamol and doxofylline treatments with different orders.Methods The subjects were inpatients who need to be treated with salbutamol and doxofylline in Department of Respiratory and Critical Care Medicine Ward,Beijing Hospital during September 2012 to December 2014.Firstly,the nurses were divided into A,B,and C groups and the admitted patients in accordance with inclusion criteria were entered into the on-duty nurses' group.The patients in the group A received intravenous injection of doxofylline after salbutamol inhalation,the patients in the group B received salbutamol inhalation and intravenous injection of doxofylline at the same time,and the patients in the group C received salbutamol inhalation after intravenous injection of doxofylline (a total of 1 to 2 treatment cycles,the treatment was stopped if adverse reactions occurred).The adverse reactions in the 3 groups were observed.Results Each group comprised 100 patients.There were 63 males in the group A and average age was (71 ±13) years;58 males in the group B and average age was (71 ± 12) years;64 males in the group C and average age was (73 ± 12) years.The diseases in patients in the 3 groups included chronic obstructive pulmonary disease,pneumonia,lung cancer,lung infection,bronchiectasis,and bronchial asthma,etc.The differences of age,gender distribution,and percentages of different diseases among the three groups were not statistically significant (all P ＞ 0.05).Totally 24 cases of adverse reactions appeared in 16 patients in the 3 groups,including 12 cases of palpitations,10 cases of shortness of breath,and 1 case of finger tremor.The incidence of adverse reactions in the 3 groups were 2％ (2/100),10％ (10/100),and 5％ (5/100),respectively.The difference between the group A and the group B was statistically significant (P =0.045).Conclusions Salbutamol inhalation and intravenous injection of doxofylline with different order had an marked impact on medication safety.The incidence of adverse reactions was the lowest when the patients were given intravenous injection of doxofylline after salbutamol inhalation.

Objective To explore the clinical value of fecal calprotectin (FCP) in peptic ulcer (PU) as an non-invasive indicator of disease activity compared with gastroscope. Methods The study was conducted in 62 patients with PU confirmed by endoscopy ( PU group) and 30 subjects with normal findings under endoscopy ( control group). Fecal sample ( weight 5-10 g) was collected within 3 days after endoscopy and FCP was measured by emzyme-linked immunosorbent assay (ELISA). The case history and clinical data were collected as well. Results The level of FCP in PU group was significantly higher than that in control group ( 154. 72 μg/g vs. 25. 18 μg/g, P < 0.001 ). In patients with PU at active stage ( n = 32), the level of FCP was significantly higher than that at scar stage (n =30,318.34 μg/g vs. 54. 10 μg/g, P <0. 01 ), and that in control group (25.18 μg/g, P <0.01), while there was no significant difference in FCP between the latter two groups ( P >0. 05 ). The level of FCP had no significant correlation with the location, size or number of the ulcer. Among patients in PU group, the level of FCP in patients presented with haematemesis or melena ( n = 20) was significantly higher than that in patients presented with other symptoms ( n = 42, 1257. 41 μg/g vs. 92. 77 μg/g, P < 0. 01 ). Conclusion The level of FCP is closely correlated with the activity of PU, which is significantly higher at active stage than that at scar stage, as well as in PU patients with bleeding than those without. Measurement of FCP is a convenient and noninvasive method with well compliance of patients, which might be used as an indicator of disease activity in PU.