Objective:To explore the clinical characteristics and prognostic risk factors of Mycoplasma pneumoniae pneumonia(MPP)in adults across different age groups,providing evidence for age-stratified management strategies.Methods:A retrospective analysis was conducted on 80 MPP patients admitted to the Respiratory Department of a hospital between January 2023 and December 2024.Patients were divided into three groups based on age:young adults(18-40 years),middle-aged adults(41-60 years),and elderly adults(≥ 61 years).Demographic features,clinical indicators,and mixed infections were analyzed.Univariate and multivariate Logistic regression were used to identify risk factors for disease severity.Results:The severity rate was significantly higher in the elderly group(41.2％)compared to the young adult group(7.1％)and middle-aged group(20.0％)(P=0.022).Elderly patients also exhibited significantly higher rates of underlying diseases(chronic lung disease:35.3％vs.3.6％in young adults),elevated inflammatory markers(C-reactive protein:68.3±19.5 mg/L vs.32.5±8.4 mg/L in young adults),mixed infections(52.9％vs.14.3％),and prolonged hospital stays(8.61±2.22 days vs.5.01±1.11 days)(P＜0.05).Multivariate analysis identified age(OR=1.79 per 10 years),chronic lung disease(OR=3.25),blood urea nitrogen ≥6 mmol/L(OR=2.44),and mixed infections(OR=4.26)as independent risk factors for severe MPP(P＜0.05).Conclusion:Clinical manifestations and prognoses of MPP in adults vary significantly across age groups.Elderly patients are characterized by high mixed infection rates,intense inflammatory responses,and renal function impairment,necessitating individualized monitoring and intervention strategies.

Objective:To explore the clinical application value of the measured femoral offset(FO)based on three-dimensional modeling of spiral computed tomography(CT)in percutaneous-assisted superior capsulotomy approach for total hip arthroplasty(THA).Methods:A total of 92 patients with fractures at hip joint who underwent percutaneous-assisted superior capsulotomy approach for THA at the 904th Hospital of People's Liberation Army Joint Service Support Force between January 2023 and June 2024 were prospectively enrolled.According to the preoperative FO median(34.8 mm)that was measured by CT,these patients were divided into high-FO group(n=46)and low-FO group(n=46).Postoperative outcomes between two groups,which included bone density T value(T value),FO value,external tilt angle and forward tilt angle of mortar cup,and the deviation of femoral stem alignment,as well as the scores of Harris Hip Score(HHS),Visual Analog Scale(VAS),positive rate of Trendelenburg sign and incidence of complication,were compared.Results:The preoperative bone density T value of high-FO group was(-1.1±0.7),which was higher than(-1.3±0.8)of low-FO group,and the difference was not significant(P>0.05).The FO was(38.5±3.4)mm in high-FO group,which was lower than(30.9±2.7)in low-FO group,and the difference was significant(t=12.356,P<0.001).The external tilt angle and forward tilt angle of mortar cup,and the deviation of femoral stem alignment of high-FO group were respectively(42.6±3.9)°,(16.8±2.6)° and(1.1±0.7)mm,which were lower than(43.4±4.1)°,(17.5±3.0)° and(1.3±0.8)mm of low-FO group,and the differences were not significant(P>0.05).The HHS scores at the 1st,3rd,6th and 12th month after surgery in high-FO group were significantly better than those of low-FO group,and the differences were significant(t=3.104,4.772,6.358,7.326,P<0.05).The VAS scores at the 3rd and 12th month after surgery in high-FO group were significantly lower than those in low-FO group,and the difference was significant(t=-9.215,-7.582,P<0.05).The positive rate of Trendelenburg sign at the 1st month after surgery in high-FO group was 15.2%(7/46),which was significantly lower than 39.1%(18/46)in low-FO group,and the difference was significant(x2=7.324,P<0.05).The used time of walking aids was shortened by 37%[(13.5±3.1)d]in high-FO group,which was significantly shorter than[(21.4±4.9)d]in low-FO group,and the difference was significant(t=9.127,P<0.05).Conclusion:Spiral CT-guided FO precision reconstruction can significantly enhance postoperative recovery quality of joint function of patients who undergo percutaneous-assisted superior capsulotomy approach for THA,and reduce the risks of abnormal gait and dislocation.

Objective:To explore the clinical characteristics and prognostic risk factors of Mycoplasma pneumoniae pneumonia(MPP)in adults across different age groups,providing evidence for age-stratified management strategies.Methods:A retrospective analysis was conducted on 80 MPP patients admitted to the Respiratory Department of a hospital between January 2023 and December 2024.Patients were divided into three groups based on age:young adults(18-40 years),middle-aged adults(41-60 years),and elderly adults(≥ 61 years).Demographic features,clinical indicators,and mixed infections were analyzed.Univariate and multivariate Logistic regression were used to identify risk factors for disease severity.Results:The severity rate was significantly higher in the elderly group(41.2％)compared to the young adult group(7.1％)and middle-aged group(20.0％)(P=0.022).Elderly patients also exhibited significantly higher rates of underlying diseases(chronic lung disease:35.3％vs.3.6％in young adults),elevated inflammatory markers(C-reactive protein:68.3±19.5 mg/L vs.32.5±8.4 mg/L in young adults),mixed infections(52.9％vs.14.3％),and prolonged hospital stays(8.61±2.22 days vs.5.01±1.11 days)(P＜0.05).Multivariate analysis identified age(OR=1.79 per 10 years),chronic lung disease(OR=3.25),blood urea nitrogen ≥6 mmol/L(OR=2.44),and mixed infections(OR=4.26)as independent risk factors for severe MPP(P＜0.05).Conclusion:Clinical manifestations and prognoses of MPP in adults vary significantly across age groups.Elderly patients are characterized by high mixed infection rates,intense inflammatory responses,and renal function impairment,necessitating individualized monitoring and intervention strategies.

Objective: To systematically analyze the research status, highlights, and advancements of five-element music therapy (FEMT) in intervening depression with bibliometric methods. Methods: Relevant research literature on FEMT for depression intervention was retrieved from China National Knowledge Infrastructure (CNKI), Wanfang Data, Chinese Science and Technology Journal Database (VIP), and Web of Science (WOS), spanning from January 1, 2000 to August 6, 2025. Bibliometric analysis was performed using Excel, VOSviewer, and CiteSpace, with a focus on dimensions like publication trends, journal distribution, institutional and author collaboration, keyword co-occurrence, clustering, and burst detection, and highly cited publications. Results: A total of 382 articles were included, comprising 304 Chinese articles and 78 English articles. Annual publication volume in this field exhibited a steady upward trend, with Chinese literature initiating earlier and maintaining dominance, while English literature demonstrated marked growth from 2019 onward. Network analysis of institutional and author collaborations revealed collaborative networks centered on research teams led by Facai LIN (Nanjing University of Chinese Medicine) and Li LI (Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine), with Chinese authors and institutions remaining dominant contributors to English literature. Keyword analysis indicated that Chinese literature emphasizes clinical applications such as “depression” “five-elements music” “five-tone therapy” and “acupuncture”, whereas English literature prioritize “music therapy” “depression” “randomized controlled trial” and “anxiety” with a focus on mechanisms and standardization. Cluster analysis revealed a paradigm shift from traditional Chinese medicine (TCM) theoretical explanations to research integrating neurobiological mechanisms and modern technologies. Analysis of highly cited literature further corroborated this trend, indicating that FEMT research is transitioning from empirical clinical exploration to evidence-based mechanistic inquiry. Conclusion FEMT research on depression shows distinct thematic emphase, with Chinese literature focusing on TCM theory and clinical applications, while English literature emphasize evidence-based mechanisms. Future research should integrate systematic reviews and high-quality clinical trials and strengthen cross-institutional collaboration to enhance mechanistic evidence and broaden the scope of FEMT.

Objective:To explore the clinical application value of the measured femoral offset(FO)based on three-dimensional modeling of spiral computed tomography(CT)in percutaneous-assisted superior capsulotomy approach for total hip arthroplasty(THA).Methods:A total of 92 patients with fractures at hip joint who underwent percutaneous-assisted superior capsulotomy approach for THA at the 904th Hospital of People's Liberation Army Joint Service Support Force between January 2023 and June 2024 were prospectively enrolled.According to the preoperative FO median(34.8 mm)that was measured by CT,these patients were divided into high-FO group(n=46)and low-FO group(n=46).Postoperative outcomes between two groups,which included bone density T value(T value),FO value,external tilt angle and forward tilt angle of mortar cup,and the deviation of femoral stem alignment,as well as the scores of Harris Hip Score(HHS),Visual Analog Scale(VAS),positive rate of Trendelenburg sign and incidence of complication,were compared.Results:The preoperative bone density T value of high-FO group was(-1.1±0.7),which was higher than(-1.3±0.8)of low-FO group,and the difference was not significant(P>0.05).The FO was(38.5±3.4)mm in high-FO group,which was lower than(30.9±2.7)in low-FO group,and the difference was significant(t=12.356,P<0.001).The external tilt angle and forward tilt angle of mortar cup,and the deviation of femoral stem alignment of high-FO group were respectively(42.6±3.9)°,(16.8±2.6)° and(1.1±0.7)mm,which were lower than(43.4±4.1)°,(17.5±3.0)° and(1.3±0.8)mm of low-FO group,and the differences were not significant(P>0.05).The HHS scores at the 1st,3rd,6th and 12th month after surgery in high-FO group were significantly better than those of low-FO group,and the differences were significant(t=3.104,4.772,6.358,7.326,P<0.05).The VAS scores at the 3rd and 12th month after surgery in high-FO group were significantly lower than those in low-FO group,and the difference was significant(t=-9.215,-7.582,P<0.05).The positive rate of Trendelenburg sign at the 1st month after surgery in high-FO group was 15.2%(7/46),which was significantly lower than 39.1%(18/46)in low-FO group,and the difference was significant(x2=7.324,P<0.05).The used time of walking aids was shortened by 37%[(13.5±3.1)d]in high-FO group,which was significantly shorter than[(21.4±4.9)d]in low-FO group,and the difference was significant(t=9.127,P<0.05).Conclusion:Spiral CT-guided FO precision reconstruction can significantly enhance postoperative recovery quality of joint function of patients who undergo percutaneous-assisted superior capsulotomy approach for THA,and reduce the risks of abnormal gait and dislocation.

The aim of this study was to investigate the trend in testicular volume changes after orchiopexy in children with cryptorchidism. The clinical data of 854 children with cryptorchidism who underwent orchiopexy between January 2013 and December 2016 in Shenzhen Children's Hospital (Shenzhen, China) were retrospectively analyzed. The mean (standard deviation) age of the patients was 2.8 (2.5) years, and the duration of follow-up ranged from 1 year to 5 years. Ultrasonography was conducted preoperatively and postoperatively. The variables analyzed included age at the time of surgery, type of surgical procedure, laterality, preoperative testicular position, preoperative and postoperative testicular volumes, and the testicular volume ratio of them. The average testicular volumes preoperatively and at 1 year, 2 years, 3 years, and 5 years postoperatively were 0.27 ml, 0.38 ml, 0.53 ml, 0.87 ml, and 1.00 ml, respectively ( P < 0.001). The corresponding testicular volume ratios were 0.67, 0.76, 0.80, 0.83, and 0.84 ( P < 0.001). The mean volume of the undescended testes was significantly smaller than the mean normative value ( P < 0.001, lower than the 10 th percentile). The postoperative testicular volumes in children with cryptorchidism were generally lower than those in healthy boys but were still greater than the 10 th percentile and exhibited an increasing trend. The older the child is at the time of surgery, the larger the gap in volume between the affected and normal testes. Although testicular volume tends to gradually increase after orchiopexy for cryptorchidism, it could not normalizes. Earlier surgery results in affected testicular volumes closer to those of healthy boys.
Humans ; Male ; Cryptorchidism/diagnostic imaging* ; Orchiopexy ; Child, Preschool ; Testis/surgery* ; Retrospective Studies ; Organ Size ; Ultrasonography ; Infant ; Child ; Postoperative Period ; Follow-Up Studies

Objective:To investigate the effects of laparoscopic transabdominal preperitoneal repair (TAPP) and Lichtenstein surgery on postoperative early pain and mobility in patients with inguinal hernia.Methods:The retrospective cohort study was conducted. The clinical data of 184 pati-ents with unilateral inguinal hernia who were admitted to Shaanxi Provincial People's Hospital from June 2021 to December 2022 were collected. There were 152 males and 32 females, aged (64±8)years. Of the 184 patients, 92 cases undergoing TAPP were divided into the TAPP group, and 92 cases under-going Lichtenstein surgery were divided into the Lichtenstein group. Observation indicators: (1) surgical situations; (2) postoperative pain; (3) postoperative mobility. Comparison of measurement data with normal distribution between groups was conducted using the independent sample t test. Paired sample t test was used for comparison within group before and after surgery. Comparison of measurement data with skewed distribution between groups was conducted using the Mann-Whitney U test. Comparison of count data between groups was conducted using the chi-square test. Results:(1) Surgical situations. Total duration of hospital stay, duration of postoperative hospital stay, expense of hospitalization were 1.70(1.00,2.00)days, 1.00(1.00,1.00)days, 14 808(14 385,15 292)yuan in the TAPP group, versus 2.12(2.00,3.00)days, 1.42(1.00,2.00)days, 10 590(9802,11 362)yuan in the Lichtenstein group, showing significant differences in the above indicators between the two groups ( Z=-3.23, -4.07, -11.72, P<0.05). (2) Postoperative pain. Score of verbal rating scale (VRS) were 1.36±0.75 and 3.22±0.66 before surgery and at 20-22 hours after surgery in the TAPP group, versus 1.34±0.80 and 3.42±0.80 in the Lichtenstein group, showing significant differences within the two groups ( t=-29.15, -31.46, P<0.05). (3) Postoperative mobility. The time from getting up to standing bedside of patients before surgery and at 20-22 hours after surgery were (5.47±1.08)seconds and (7.94±2.23)seconds in the TAPP group, versus (5.87±1.13)seconds and (11.59±1.88)seconds in the Lichtenstein group, showing a significant difference at 20-22 hours after surgery between the two groups and significant differences within the two groups ( t=-11.99, -15.64, -27.26, P<0.05). The time for hip flexion 90° of patients before surgery and at 20-22 hours after surgery were (0.74±0.32)seconds and (1.23±0.54)seconds in the TAPP group, versus (0.81±0.19)seconds and (1.97±0.69)seconds in the Lichtenstein group, showing a significant difference at 20-22 hours after surgery between the two groups and significant differences within the two groups ( t=-8.11, -16.53, -17.81, P<0.05). The time for walking 10 meters of patients before surgery and at 20-22 hours after surgery were (10.30±1.53)seconds and (12.80±1.67)seconds in the TAPP group, versus (10.38±1.35)seconds and (18.35±1.69)seconds in the Lichtenstein group, showing a significant difference at 20-22 hours after surgery between the two groups and significant differences within the two groups ( t=-22.44, -33.66, -32.46, P<0.05). The time for walking 20 meters of patients before surgery and at 20-22 hours after surgery were (17.87±2.89)seconds and (24.16±2.54)seconds in the TAPP group, versus (18.02±2.82)seconds and (32.64±2.56)seconds in the Lichtenstein group, showing a significant difference at 20-22 hours after surgery between the two groups and significant differences within the two groups ( t=-22.55, -38.75, -34.59, P<0.05). Conclusion:Compared to Lichtenstein surgery, patients with TAPP experience faster recovery of mobility, earlier discharge, and higher expense of hospitalization.

Objective To study the efficacy and safety of apolipoprotein E(ApoE)gene and solute carrier organic anion transporter family 1B1(SLCO1B1)gene guided rosuvastatin in regulating lipid.Methods According to ApoE genotype,patients with dyslipidemia were divided into E2 group(ε2/ε2,ε2/ε3),E3 group(ε3/ε3,ε2/ε4)and E4 group(ε3/s4,ε4/ε4).According to SLCO1B1 genotype,they were divided into TT group(*1a/*1a,*la/*1b,*lb/*lb),TC group(*la/*5,*1a/*15,*lb/*15)and CC group(*15/*15).All patients were given rosuvastatin calcium tablets 10 mg each time,once a night,orally for 6 months.The levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)in three groups of ApoE genotype patients were compared.The levels of alanine aminotransferase(GPT),glutamic-oxalacetic aminotransferase(GOT),creatine kinase(CK),creatinine(Cr),fasting blood glucose(FBG)and glycated hemoglobin(HbA1C)in SLCO1B1 genotype patients in 3 groups;the occurrence of myalgia during the study period was observed.Results A total of 1 693 patients were included,including 204 patients in E2 group,1 226 patients in E3 group and 263 patients in E4 group.Among them,there were 1 340 cases in TT group,334 cases in TC group and 19 cases in CC group.After rosuvastatin treatment,the TG levels of E2,E3 and E4 groups were(1.34±1.17),(1.20±0.43)and(1.34±0.55)mmol·L-1;the LDL-C levels were(1.84±0.52),(2.09±0.66)and(2.25±0.51)mmol·L-1;the HDL-C levels were(1.20±0.26),(1.13±0.27)and(1.01±0.21)mmol·L-1.Compared with the E3 and E4 groups,the levels of TG and LDL-C in E2 group were significantly decreased;the HDL-C levels in E2 and E3 groups were significantly higher than that in E4 group(all P＜0.05).After rosuvastatin treatment,the CK levels in CC group were significantly higher than that in TT and TC groups(113 vs 96,94 U·L-1,all P＜0.05).The incidences of myalgia in TT,TC and CC groups were 3.13％,5.99％and 10.53％(P＜0.05).Conclusion After rosuvastatin treatment,ε2 allele and E2/E3 genotype were more effective in reducing TG and LDL-C levels in patients with dyslipidemia.SLCO1B1 521T＞C:CC genotype is more prone to myalgia,521T＞C genotypes did not lead to diabetes.

Objective To study the efficacy and safety of apolipoprotein E(ApoE)gene and solute carrier organic anion transporter family 1B1(SLCO1B1)gene guided rosuvastatin in regulating lipid.Methods According to ApoE genotype,patients with dyslipidemia were divided into E2 group(ε2/ε2,ε2/ε3),E3 group(ε3/ε3,ε2/ε4)and E4 group(ε3/s4,ε4/ε4).According to SLCO1B1 genotype,they were divided into TT group(*1a/*1a,*la/*1b,*lb/*lb),TC group(*la/*5,*1a/*15,*lb/*15)and CC group(*15/*15).All patients were given rosuvastatin calcium tablets 10 mg each time,once a night,orally for 6 months.The levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)in three groups of ApoE genotype patients were compared.The levels of alanine aminotransferase(GPT),glutamic-oxalacetic aminotransferase(GOT),creatine kinase(CK),creatinine(Cr),fasting blood glucose(FBG)and glycated hemoglobin(HbA1C)in SLCO1B1 genotype patients in 3 groups;the occurrence of myalgia during the study period was observed.Results A total of 1 693 patients were included,including 204 patients in E2 group,1 226 patients in E3 group and 263 patients in E4 group.Among them,there were 1 340 cases in TT group,334 cases in TC group and 19 cases in CC group.After rosuvastatin treatment,the TG levels of E2,E3 and E4 groups were(1.34±1.17),(1.20±0.43)and(1.34±0.55)mmol·L-1;the LDL-C levels were(1.84±0.52),(2.09±0.66)and(2.25±0.51)mmol·L-1;the HDL-C levels were(1.20±0.26),(1.13±0.27)and(1.01±0.21)mmol·L-1.Compared with the E3 and E4 groups,the levels of TG and LDL-C in E2 group were significantly decreased;the HDL-C levels in E2 and E3 groups were significantly higher than that in E4 group(all P＜0.05).After rosuvastatin treatment,the CK levels in CC group were significantly higher than that in TT and TC groups(113 vs 96,94 U·L-1,all P＜0.05).The incidences of myalgia in TT,TC and CC groups were 3.13％,5.99％and 10.53％(P＜0.05).Conclusion After rosuvastatin treatment,ε2 allele and E2/E3 genotype were more effective in reducing TG and LDL-C levels in patients with dyslipidemia.SLCO1B1 521T＞C:CC genotype is more prone to myalgia,521T＞C genotypes did not lead to diabetes.

Objective:To investigate the effects of laparoscopic transabdominal preperitoneal repair (TAPP) and Lichtenstein surgery on postoperative early pain and mobility in patients with inguinal hernia.Methods:The retrospective cohort study was conducted. The clinical data of 184 pati-ents with unilateral inguinal hernia who were admitted to Shaanxi Provincial People's Hospital from June 2021 to December 2022 were collected. There were 152 males and 32 females, aged (64±8)years. Of the 184 patients, 92 cases undergoing TAPP were divided into the TAPP group, and 92 cases under-going Lichtenstein surgery were divided into the Lichtenstein group. Observation indicators: (1) surgical situations; (2) postoperative pain; (3) postoperative mobility. Comparison of measurement data with normal distribution between groups was conducted using the independent sample t test. Paired sample t test was used for comparison within group before and after surgery. Comparison of measurement data with skewed distribution between groups was conducted using the Mann-Whitney U test. Comparison of count data between groups was conducted using the chi-square test. Results:(1) Surgical situations. Total duration of hospital stay, duration of postoperative hospital stay, expense of hospitalization were 1.70(1.00,2.00)days, 1.00(1.00,1.00)days, 14 808(14 385,15 292)yuan in the TAPP group, versus 2.12(2.00,3.00)days, 1.42(1.00,2.00)days, 10 590(9802,11 362)yuan in the Lichtenstein group, showing significant differences in the above indicators between the two groups ( Z=-3.23, -4.07, -11.72, P<0.05). (2) Postoperative pain. Score of verbal rating scale (VRS) were 1.36±0.75 and 3.22±0.66 before surgery and at 20-22 hours after surgery in the TAPP group, versus 1.34±0.80 and 3.42±0.80 in the Lichtenstein group, showing significant differences within the two groups ( t=-29.15, -31.46, P<0.05). (3) Postoperative mobility. The time from getting up to standing bedside of patients before surgery and at 20-22 hours after surgery were (5.47±1.08)seconds and (7.94±2.23)seconds in the TAPP group, versus (5.87±1.13)seconds and (11.59±1.88)seconds in the Lichtenstein group, showing a significant difference at 20-22 hours after surgery between the two groups and significant differences within the two groups ( t=-11.99, -15.64, -27.26, P<0.05). The time for hip flexion 90° of patients before surgery and at 20-22 hours after surgery were (0.74±0.32)seconds and (1.23±0.54)seconds in the TAPP group, versus (0.81±0.19)seconds and (1.97±0.69)seconds in the Lichtenstein group, showing a significant difference at 20-22 hours after surgery between the two groups and significant differences within the two groups ( t=-8.11, -16.53, -17.81, P<0.05). The time for walking 10 meters of patients before surgery and at 20-22 hours after surgery were (10.30±1.53)seconds and (12.80±1.67)seconds in the TAPP group, versus (10.38±1.35)seconds and (18.35±1.69)seconds in the Lichtenstein group, showing a significant difference at 20-22 hours after surgery between the two groups and significant differences within the two groups ( t=-22.44, -33.66, -32.46, P<0.05). The time for walking 20 meters of patients before surgery and at 20-22 hours after surgery were (17.87±2.89)seconds and (24.16±2.54)seconds in the TAPP group, versus (18.02±2.82)seconds and (32.64±2.56)seconds in the Lichtenstein group, showing a significant difference at 20-22 hours after surgery between the two groups and significant differences within the two groups ( t=-22.55, -38.75, -34.59, P<0.05). Conclusion:Compared to Lichtenstein surgery, patients with TAPP experience faster recovery of mobility, earlier discharge, and higher expense of hospitalization.