3.Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR
Jaegyun LIM ; Seunghyun JEON ; Hyun Young SHIN ; Moon Jung KIM ; Yu Min SEONG ; Wang Jun LEE ; Kang Won CHOE ; Yu Min KANG ; Baeckseung LEE ; Sang Joon PARK
Journal of Korean Medical Science 2020;35(6):79-
Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
China
;
Clothing
;
Commerce
;
Coronavirus
;
Fever
;
Hospitalization
;
Humans
;
Korea
;
Male
;
Pneumonia
;
Thorax
;
Viral Load
4.Incidence, Risk Factors and Prognosis of Acute Kidney Injury Following Hematopoietic Stem Cell Transplant: A Pilot Study
Amani Anwar KHALIL ; Laiali T KHALIL ; Abdalla AWIDI
International Journal of Stem Cells 2019;12(1):43-50
BACKGROUND AND OBJECTIVES: The burden of acute kidney injury (AKI) has not been explored in Jordanian patients who receive hematopoietic stem cell transplant (HSCT). The aim of this study was to evaluate the frequency, risk factors, and mortality of AKI among patients who underwent HSCT. METHODS: A retrospective pilot study included 70 adult patients who received peripheral HSCT was conducted. Weekly measurement of serum creatinine (SCr) was obtained for 3 months after chemotherapy and HSCT. Then, stages of Risk, Injury, and Failure of Kidney were determined based on the Kidney Disease for Improving Global Outcomes (KDIGO). RESULTS: The median follow-up was 41 months. Mortality was reported in 16 patients (23%). Out of 60 patients that had SCr values, 19 patients (31.6%) had AKI in 90 days after chemotherapy. Allogeneic HSCT, male donors, high-dose melphalan protocols and values of blood urea nitrogen (BUN) were significantly higher among patients with AKI. CONCLUSIONS: Combining many nephrotoxic drugs and dosing adjustments should be considered in uniform protocols. Multidisciplinary care should be utilized to assess early kidney dysfunction that decreases adverse events and improves outcomes.
Acute Kidney Injury
;
Adult
;
Blood Urea Nitrogen
;
Clothing
;
Creatinine
;
Drug Therapy
;
Follow-Up Studies
;
Hematopoietic Stem Cells
;
Humans
;
Incidence
;
Jordan
;
Kidney
;
Kidney Diseases
;
Male
;
Melphalan
;
Mortality
;
Pilot Projects
;
Prognosis
;
Retrospective Studies
;
Risk Factors
;
Tissue Donors
5.Prosthetic rehabilitation for a maxillectomy patient using 3D printing assisted closed hollow bulb obturator: a case report
Miju OH ; Jonghyuk LEE ; Young Gyun SONG
Journal of Dental Rehabilitation and Applied Science 2019;35(3):191-198
This case report presents a closed hollow bulb obturator made by 3D printing for a maxillectomy patient. Final impression was taken according to the instructions and impression trays provided by the Magic denture™ system. Vertical dimension, facial appearance, and retention had been checked with the try-in denture. The try-in denture was corrected and adjusted to fulfill the demand of the patients, then these were reflected to the final design of the denture. The defect area was designed as a closed hollow bulb shape to reduce the weight and to provide uniform thickness of the denture. The patient satisfied with the esthetics and function of the denture.
Clothing
;
Dentures
;
Esthetics
;
Humans
;
Magic
;
Printing, Three-Dimensional
;
Rehabilitation
;
Vertical Dimension
6.Study on Assessment and Treatment Patterns of Speech-Language Pathologists in Pediatric Vocal Problem Through Multicenter Survey
Jong Geun LEE ; Seung Hwan BANG ; Jae Min JEON ; Jung Kyu LEE ; Angela Yun KIM ; Jeong Soo WOO ; Jae Gu CHO
Journal of the Korean Society of Laryngology Phoniatrics and Logopedics 2019;30(1):39-47
BACKGROUND AND OBJECTIVES: Pediatric vocal health problems are relatively common. However, it is not yet well studied whether uniform diagnosis and treatment is done properly in South Korea. The purpose of this study was to investigate the methods that the Korean speech therapists use to diagnose and treat pediatric voice problem. MATERIALS AND METHOD: An anonymous online questionnaire was administered to 32 speech language therapists registered at the Korean laryngeal speech linguistics society detailing demographics, employment institution, general management of pediatric patients with vocal problem including assessment and treatment procedures. RESULTS: Current practice patterns were analyzed on 32 speech language therapists providing services in South Korea mostly working at tertiary university hospital. One third of pediatric patients were assessed without proceeding to treatment. One fifth of patients were treated without assessment. Perceptual assessment was the main pre-treatment assessment methods used. Treatment was done in the following order : Voice rest, SOVT, yawn-sigh and resonant voice. Post-treatment evaluation was used in the following order : Instrumental assessment, clinical judgment, and recording comparison. CONCLUSION: Speech language therapists practice in South Korea mostly follows the ASHA practice guidelines. However, there are still great amount of cases in which only the evaluation was done without appropriate treatment. Further research is needed to make SPLs more systematic and efficient for evaluating and treating pediatric vocal patients.
Anonyms and Pseudonyms
;
Clothing
;
Demography
;
Diagnosis
;
Employment
;
Humans
;
Judgment
;
Korea
;
Linguistics
;
Methods
;
Voice
7.The efficacy of wet wrap therapy in children with atopic dermatitis in a single center.
Allergy, Asthma & Respiratory Disease 2019;7(1):13-21
PURPOSE: Wet wrap therapy is a well-known treatment for severe atopic dermatitis (AD). However, wet wrap therapy with usual bandage was a troublesome and time-consuming process of application. The aim of this study was to evaluate the efficacy, safety and convenience of wet wrap therapy with new garments in children with moderate-to-severe AD. METHODS: We compared 56 AD children treated with wet wrap therapy and 14 AD children treated with only conventional therapy. We retrospectively reviewed the clinical features, change of SCORing Atopic Dermatitis (SCORAD) index, adverse effects and parent's reports. RESULTS: The initial mean SCORAD index was 60.3±15.3 points. No significant differences in sex, age, initial SCORAD index, total eosinophil count, total IgE level, food allergen sensitization, inhalant allergen sensitization or associated allergic diseases were found between the wet wrap and conventional groups. The pharmacological and nonpharmacological interventions except wet wrap therapy were same in the 2 groups. Wet wrap therapy with garments or tubular bandage was easily done one time per day overnight in 10.6±3.5 days by parents. Improvement in total SCORAD index, intensity, subjective symptoms and pruritus were significantly higher in the wet wrap group than in the conventional group (36.2 vs. 26.9, 6.0 vs. 4.0, 9.9 vs. 7.4, and 4.8 vs. 3.6 points). No folliculitis and serious adverse effects were reported. CONCLUSION: Wet wrap therapy with new garments could be easily done by parents. Wet wrap therapy may be effective and safe in controlling moderate-to-severe AD in children.
Bandages
;
Child*
;
Clothing
;
Dermatitis, Atopic*
;
Eosinophils
;
Folliculitis
;
Humans
;
Immunoglobulin E
;
Parents
;
Pruritus
;
Retrospective Studies
8.Cytopathologic Features of Secretory Carcinoma of Salivary Gland: Report of Two Cases
Young Ah KIM ; Jae Won JOUNG ; Sun Jae LEE ; Hoon Kyu OH ; Chang Ho CHO ; Woo Jung SUNG
Journal of Pathology and Translational Medicine 2019;53(1):70-74
Secretory carcinoma of the salivary gland (SC) is a newly introduced rare salivary gland tumor that shares histological, immunohistochemical, and genetic characteristics with secretory carcinoma of the breast. Here, we report the cytologic features of two cases of SC confirmed by surgical resection. In these two cases, SC was incidentally detected in a 64-year-old female and a 56-yearold male. Fine needle aspiration cytology revealed nests of tumor cells with a papillary or glandular structure floating in mucinous secretions. The tumor cells demonstrated uniform, round, smooth nuclear contours and distinct nucleoli. Multiple characteristic cytoplasmic vacuoles were revealed. Singly scattered tumor cells frequently showed variable sized cytoplasmic vacuoles. The cytopathologic diagnosis of SC should be considered when characteristic cytological findings are revealed. Further immunohistochemistry and gene analyses are helpful to diagnose SC.
Biopsy, Fine-Needle
;
Breast
;
Clothing
;
Cytoplasm
;
Diagnosis
;
Female
;
Humans
;
Immunohistochemistry
;
Male
;
Mammary Analogue Secretory Carcinoma
;
Middle Aged
;
Mucins
;
Salivary Glands
;
Vacuoles
9.Efficiency of Air Bubble Removal in Preparation of Low-Profile Angioplasty Balloon Catheter: Bench-Top Comparison of Six Methods
Joon Ho CHOI ; Seon Moon HWANG ; Deok Hee LEE
Neurointervention 2019;14(1):27-34
PURPOSE: Complete removal of air bubbles from balloons for neurovascular angioplasty is cumbersome. We compared the preparation difficulty, air removal efficiency, and air collection pattern of six different balloon catheter preparation methods to propose a better preparation method for both initial and second balloon uses, especially for small-profile angioplasty balloon catheters. MATERIALS AND METHODS: A total of 18 neurovascular angioplasty balloon catheters with nominal diameters of 2 mm were prepared to test six different preparation methods: the instruction for use method (method A), simplified method using a syringe (method B) and four newly devised preparation methods using inflating devices (methods C–F). Serial radiographs were obtained while the balloons were gradually inflated. We measured the time for each preparation and the bubble number, analyzed their distribution in the balloon, and calculated the contrast filling ratio (contrast filling area/total balloon area) for initial and second ballooning. The whole process was repeated three times. RESULTS: The preparation time varied widely (11.5 seconds [method D] to 73.3 seconds [method A]). On initial inflation, the contrast filling ratio at 8 atm was the highest (100%) with methods A and F. On second inflation, the ratio was again highest with method A (99.5%), followed by method F (99.2%). Initial ballooning tended to show a uniform pattern of single bubble in the distal segment of the balloon; in contrast, second ballooning showed varying patterns in which the bubbles were multiple and randomly distributed. CONCLUSION: None of the six methods were able to completely exclude air bubbles from the balloon catheters including the second ballooning; however, the method of repeating aspiration with high-volume inflating device (method F) could be a practical option considering the simplicity and efficiency of preparation.
Angioplasty
;
Angioplasty, Balloon
;
Catheters
;
Clothing
;
Embolism, Air
;
Equipment Failure
;
Inflation, Economic
;
Intracranial Arteriosclerosis
;
Methods
;
Syringes
10.In vitro evaluation of the wear resistance of provisional resin materials fabricated by different methods
Jong Ju AHN ; Jung Bo HUH ; Jae Won CHOI
The Journal of Korean Academy of Prosthodontics 2019;57(2):110-117
PURPOSE: This study was to evaluate the wear resistance of 3D printed, milled, and conventionally cured provisional resin materials. MATERIALS AND METHODS: Four types of resin materials made with different methods were examined: Stereolithography apparatus (SLA) 3D printed resin (S3P), digital light processing (DLP) 3D printed resin (D3P), milled resin (MIL), conventionally self-cured resin (CON). In the 3D printed resin specimens, the build orientation and layer thickness were set to 0° and 100 µm, respectively. The specimens were tested in a 2-axis chewing simulator with the steatite as the antagonist under thermocycling condition (5 kg, 30,000 cycles, 0.8 Hz, 5℃/55℃). Wear losses of the specimens were calculated using CAD software and scanning electron microscope (SEM) was used to investigate wear surface of the specimens. Statistical significance was determined using One-way ANOVA and Dunnett T3 analysis (α = .05). RESULTS: Wear losses of the S3P, D3P, and MIL groups significantly smaller than those of the CON group (P < .05). There was no significant difference among S3P, D3P, and MIL group (P > .05). In the SEM observations, in the S3P and D3P groups, vertical cracks were observed in the sliding direction of the antagonist. In the MIL group, there was an overall uniform wear surface, whereas in the CON group, a distinct wear track and numerous bubbles were observed. CONCLUSION: Within the limits of this study, provisional resin materials made with 3D printing show adequate wear resistance for applications in dentistry.
Clothing
;
Dentistry
;
In Vitro Techniques
;
Mastication
;
Methods
;
Printing, Three-Dimensional

Result Analysis
Print
Save
E-mail