1.Association between fruit and vegetable allergies and pollen-food allergy syndrome in Japanese children: a multicenter cross-sectional case series
Yutaka TAKEMURA ; Yuri TAKAOKA ; Tomoyuki ARIMA ; Hiroki MASUMI ; Koji YAMASAKI ; Megumi NAGAI ; Keisuke SUGIMOTO ; Masaaki HAMADA ; Tomoko TAKANO ; Masaaki DOI ; Tomoko KAWAKAMI ; Makoto KAMEDA
Asia Pacific Allergy 2020;10(1):9-
BACKGROUND: Recently, the prevalence of food allergies during childhood is increasing, with fruits being common allergens. However, data on allergens that cause fruit and vegetable allergies and pollen-food allergy syndrome (PFAS) in childhood are relatively few. This study aimed to examine the allergens in fruit and vegetable allergies in pediatric patients and to determine the association between fruit and vegetable allergies and PFAS.OBJECTIVE: This study aimed to examine the current status of fruit and vegetable allergies in Japanese children.METHODS: This was a multicenter case series observational study. The participants included children aged <15 years who developed allergic symptoms after eating fruits and vegetables and subsequently received treatment in the Pediatric Department of 6 hospitals in the Osaka Prefecture in Japan during the study period from August 2016 to July 2017. Participants' information was obtained using a questionnaire, and data were obtained by performing several types of allergy tests using blood samples.RESULTS: A total of 97 children (median age, 9 years; 56 males) were included in the study. Apple was the most common allergen, followed by peach, kiwi, cantaloupe, and watermelon. A total of 74 participants (76%) exhibited allergic symptoms due to PFAS; moreover, pathogenesis-related protein-10 (PR-10) was the most common allergen superfamily. On the contrary, in the group where neither PR-10 nor profilin was sensitized, kiwi and banana were the most common allergens, and the age of onset was lower than that in the PFAS group. Specific antibody titer was significantly associated with Birch for Bet v1 and latex for Bet v2 (r = 0.99 and r = 0.89).CONCLUSION: When we examine patients with fruit and vegetable allergies, we should first consider PFAS even in childhood specifically for children greater than 4 years old.
Age of Onset
;
Allergens
;
Asian Continental Ancestry Group
;
Betula
;
Child
;
Citrullus
;
Clinical Study
;
Cucumis melo
;
Eating
;
Food Hypersensitivity
;
Fruit
;
Humans
;
Hypersensitivity
;
Japan
;
Latex
;
Musa
;
Observational Study
;
Prevalence
;
Profilins
;
Prunus persica
;
Rhinitis
;
Rhinitis, Allergic, Seasonal
;
Vegetables
2.Selective laser trabeculoplasty vs. topical medications for step-up treatment in primary open angle glaucoma: comparing clinical effectiveness, quality of life and cost-effectiveness
Yong Meng Hsien ; Jemaima Che Hamzah
The Medical Journal of Malaysia 2020;75(4):348-
Introduction: The aim of this study was to investigate the clinical
effectiveness, health related quality of life (HRQoL) and cost
effectiveness of selective laser trabeculoplasty (SLT) compared to
topical anti-glaucoma medications in step-up treatment of patients
with primary open angle glaucoma (POAG).
Methods: Seventeen POAG patients with suboptimal IOP control
despite pre-existing topical medications were subjected to adjunct
SLT (50 applications 180 degrees) or second line medical therapy.
Current medications were continued, and patients were followed
up for 6 months for degree of intraocular pressure (IOP) lowering.
HRQoL was assessed using Glaucoma Quality of Life 36-item
(GlauQoL-36), Assessment of Quality of Life-7D (AQoL-7D) and
Vision related Quality of Life (VisQoL). Costs involved were
calculated and compared to the effect (IOP reduction) achieved in
each arm.
Results: Ten patients were in the SLT group and 7 in the
topical medication (MED) group. Mean baseline intraocular
pressure (IOP) was 18.90±3.48mmHg in SLT group and
15.57±2.23mmHg in MED group. Mean reduction of IOP was
4.30±1.64mmHg in SLT group and 2.71±2.56 mmHg in MED
group at 6 months which was not statistically significant
(p=0.14) between two groups. All the HRQoL questionnaires
did not show significant changes in the groups or between
groups when compared baseline with 6-month post treatment
(p-values ranging from 0.247 to 0.987). For every 1mmHg
reduction in IOP, cost involved in MED group (RM53.61) was
165% of the cost involved in SLT group (RM32.56).
Discussion and Conclusion: This study has shown that SLT was
as effective clinically and tolerable as topical anti glaucoma
medications and was possibly more cost effective in the step-up
treatment of patients with POAG at 6 months follow- up.
selective laser traeculoplasty
;
topical antiglaucoma, clinical effectiveness
;
quality o0f life
;
cost effectiveness
;
primary open angle glaucoma
;
prospective pilot cohort study
3.Influence of implant-abutment connection structure on peri-implant bone level in a second molar: A 1-year randomized controlled trial
Jin Cheol KIM ; Jungwon LEE ; Sungtae KIM ; Ki Tae KOO ; Hae Young KIM ; In Sung Luke YEO
The Journal of Advanced Prosthodontics 2019;11(3):147-154
PURPOSE: This study aimed to evaluate the effect of two different implant-abutment connection structures with identical implant design on peri-implant bone level. MATERIALS AND METHODS: This clinical study was a patient-blind randomized controlled trial following the CONSORT 2010 checklists. This trial was conducted in 24 patients recruited between March 2013 and July 2015. Implants with internal friction connection were compared to those with external hex connection. One implant for each patient was installed, replacing the second molar. Implant-supported crowns were delivered at four months after implant insertion. Standardized periapical radiographs were taken at prosthesis delivery (baseline), and one year after delivery. On the radiographs, distance from implant shoulder to first bone-to-implant contact (DIB) and peri-implant area were measured, which were the primary and secondary outcome, respectively. RESULTS: Eleven external and eleven internal implants were analyzed. Mean changes of DIB from baseline to 1-year postloading were 0.59 (0.95) mm for the external and 0.01 (0.68) mm for the internal connection. Although no significant differences were found between the two groups, medium effect size was found in DIB between the connections (Cohen's d = 0.67). CONCLUSION: Considering the effect size in DIB, this study suggested the possibility of the internal friction connection structure for more effective preservation of marginal bone.
Alveolar Bone Loss
;
Checklist
;
Clinical Study
;
Crowns
;
Dental Implant-Abutment Design
;
Friction
;
Humans
;
Molar
;
Prostheses and Implants
;
Shoulder
4.Comparative clinical study of the marginal discrepancy of fixed dental prosthesis fabricated by the milling-sintering method using a presintered alloy
Mijoo KIM ; Jaewon KIM ; Hang Nga MAI ; Tae Yub KWON ; Yong Do CHOI ; Cheong Hee LEE ; Du Hyeong LEE
The Journal of Advanced Prosthodontics 2019;11(5):280-285
PURPOSE: The present study was designed to examine the clinical fit of fixed dental prosthesis fabricated by the milling-sintering method using a presintered cobalt-chromium alloy. MATERIALS AND METHODS: Two single metal-ceramic crowns were fabricated via milling-sintering method and casting method in each of the twelve consecutive patients who required an implant-supported fixed prosthesis. In the milling-sintering method, the prosthetic coping was designed in computer software, and the design was converted to a non-precious alloy coping using milling and post-sintering process. In the casting method, the conventional manual fabrication process was applied. The absolute marginal discrepancy of the prostheses was evaluated intraorally using the triple-scan technique. Statistical analysis was conducted using Mann-Whitney U test (α=.05). RESULTS: Eight patients (66.7%) showed a lower marginal discrepancy of the prostheses made using the milling-sintering method than that of the prosthesis made by the casting method. Statistically, the misfit of the prosthesis fabricated using the milling-sintering method was not significantly different from that fabricated using the casting method (P=.782). There was no tendency between the amount of marginal discrepancy and the measurement point. CONCLUSION: The overall marginal fit of prosthesis fabricated by milling-sintering using a presintered alloy was comparable to that of the prosthesis fabricated by the conventional casting method in clinical use.
Alloys
;
Clinical Study
;
Crowns
;
Dental Prosthesis
;
Humans
;
Methods
;
Prostheses and Implants
5.Accuracy of digital and conventional dental implant impressions for fixed partial dentures: A comparative clinical study
Agne GEDRIMIENE ; Rimas ADASKEVICIUS ; Vygandas RUTKUNAS
The Journal of Advanced Prosthodontics 2019;11(5):271-279
PURPOSE: The newest technologies for digital implant impression (DII) taking are developing rapidly and showing acceptable clinical results. However, scientific literature is lacking data from clinical studies about the accuracy of DII. The aim of this study was to compare digital and conventional dental implant impressions (CII) in a clinical environment. MATERIALS AND METHODS: Twenty-four fixed zirconia restorations supported by 2 implants were fabricated using conventional open-tray impression technique with splinted transfers (CII group) and scan with Trios 3 IOS (3Shape) (DII group). After multiple verification procedures, master models were scanned using laboratory scanner D800 (3Shape). 3D models from conventional and digital workflow were imported to reverse engineering software and superimposed with high resolution 3D CAD models of scan bodies. Distance between center points, angulation, rotation, vertical shift, and surface mismatch of the scan bodies were measured and compared between conventional and digital impressions. RESULTS: Statistically significant differences were found for: a) inter-implant distance, b) rotation, c) vertical shift, and d) surface mismatch differences, comparing DII and CII groups for mesial and dist al implant scan bodies (P≤.05). CONCLUSION: Recorded linear differences between digital and conventional impressions were of limited clinical significance with two implant-supported restorations.
Clinical Study
;
Dental Implants
;
Denture, Partial, Fixed
;
Jupiter
;
Splints
6.PECS II block is associated with lower incidence of chronic pain after breast surgery
Alessandro DE CASSAI ; Claudio BONANNO ; Ludovica SANDEI ; Francesco FINOZZI ; Michele CARRON ; Alberto MARCHET
The Korean Journal of Pain 2019;32(4):286-291
BACKGROUND: Breast cancer is complicated by a high incidence of chronic postoperative pain (25%–60%). Regional anesthesia might play an important role in lowering the incidence of chronic pain; however it is not known if the pectoral nerve block (PECS block), which is commonly used for breast surgery, is able to prevent this complication. Our main objective was therefore to detect any association between the PECS block and chronic pain at 3, 6, 9, and 12 months in patients undergoing breast surgery. METHODS: We conducted a prospective, monocentric, observational study. We enrolled 140 consecutive patients undergoing breast surgery and divided them in patients receiving a PECS block and general anesthesia (PECS group) and patients receiving only general anesthesia (GA group). Then we considered both intraoperative variables (intravenous opioids administration), postoperative data (pain suffered by the patients during the first 24 postoperative hours and the need for additional analgesic administration) and development and persistence of chronic pain (at 3, 6, 9, and 12 mo). RESULTS: The PECS group had a lower incidence of chronic pain at 3 months (14.9% vs. 31.8%, P = 0.039), needed less intraoperative opioids (fentanyl 1.61 μg/kg/hr vs. 3.3 μg/kg/hr, P < 0.001) and had less postoperative pain (3 vs. 4, P = 0.017). CONCLUSIONS: The PECS block might play an important role in lowering incidence of chronic pain, but further studies are needed.
Analgesics, Opioid
;
Anesthesia, Conduction
;
Anesthesia, General
;
Anesthesia, Local
;
Breast Neoplasms
;
Breast
;
Chronic Pain
;
Clinical Study
;
Humans
;
Incidence
;
Nerve Block
;
Observational Study
;
Pain, Postoperative
;
Prospective Studies
;
Thoracic Nerves
7.Extracorporeal Shock Wave Therapy in Peyronie's Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study
Marina DI MAURO ; Giorgio Ivan RUSSO ; Pier Andrea DELLA CAMERA ; Fabrizio DI MAIDA ; Gianmartin CITO ; Nicola MONDAINI ; Marco CAPECE ; Marco FALCONE ; Francesco SESSA ; Andrea MARI ; Riccardo CAMPI ; Carlotta SABINI ; Sergio SERNI ; Mauro GACCI ; Andrea MINERVINI ; Marco CARINI ; Sebastiano CIMINO ; Girolamo MORELLI ; Andrea COCCI
The World Journal of Men's Health 2019;37(3):339-346
PURPOSE: In this study, we aimed to determine the role of extracorporeal shockwave therapy (ESWT) in the management of Peyronie's disease (PD). MATERIALS AND METHODS: A total of 325 patients suffering from PD were enrolled in this single-arm clinical study. All patients were received ESWT using a schedule of 1 treatment/wk. Penile curvature was measured by a goniometer after intracavernosal drug-induced erection using Alprostadil. Plaque size was measured with a ruler and sexual function assessed by the international index of erectile function (IIEF)-15 score. Severity of erectile dysfunction was classified as severe (IIEF-15 ≤10), moderate (IIEF-15 between 11 and 16), or mild (IIEF-15 between 17 and 25). Results were evaluated at baseline and 3 months after the treatment. RESULTS: All the patients completed the study protocol. Median age was 59.0 years (55.0–64.0 years). After treatment, the median (interquartile range, IQR) plaque size reduced from 1.78 cm2 (1.43–2.17 cm2) to 1.53 cm2 (1.31–1.96 cm2) (p<0.001); the median (IQR) penile length in erection increased from 13.0 cm (12.0–14.0 cm) to 14 cm (13.0–15.0 cm) (p<0.001) and the median (IQR) penile curvature from 30.4° (22.2°–35.4°) to 25.0° (20.2°–30.4°) (p<0.001). We also observed a decrease in pain assessed by visual analogue scale (7 vs. 3; p<0.001), an improvement in each of the IIEF sub-domains (p<0.001) and an improvement in all three PD questionnaire domains (p<0.001). CONCLUSIONS: Based on our findings, ESWT could be considered a safe and efficient minimally invasive option for the management of the patients suffering from PD.
Alprostadil
;
Appointments and Schedules
;
Clinical Study
;
Erectile Dysfunction
;
Humans
;
Male
;
Observational Study
;
Penile Diseases
;
Penile Induration
;
Shock
;
Treatment Outcome
8.The Clinical Efficacy and Safety of Four-Weekly Docetaxel as First-Line Therapy in Elderly Lung Cancer Patients with Squamous Cell Carcinoma
Jong Hyun CHOI ; Juwhan CHOI ; Sang Mi CHUNG ; Jee Youn OH ; Young Seok LEE ; Kyung Hoon MIN ; Gyu Young HUR ; Jae Jeong SHIM ; Kyung Ho KANG ; Hyun Kyung LEE ; Sung Yong LEE
Tuberculosis and Respiratory Diseases 2019;82(3):211-216
BACKGROUND: Docetaxel is one of the standard treatments for advanced non-small cell lung cancer. Docetaxel is usually administered in a 3-week schedule, but there is significant toxicity. In this phase II clinical study, we investigated the efficacy and safety of a 4-weekly schedule of docetaxel monotherapy, as first-line chemotherapy for advanced squamous cell carcinoma in elderly lung cancer patients. METHODS: Patients with stage IIIB/ IV lung squamous-cell carcinoma age 70 or older, that had not undergone cytotoxic chemotherapy were enrolled. Patients received docetaxel 25 mg/m2 on days 1, 8, and 15, every 4 weeks. Primary endpoint was the objective response rate (ORR). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity profiles. RESULTS: A total of 19 patients were enrolled. Among 19 patients, 17 were for evaluated efficacy and safety. In the intent-to-treat population, ORR and disease control rate (DCR) were 11.8% and 47.1%, respectively. In the response evaluable population, ORR was 16.7% and DCR was 66.7%. Median PFS and OS were 3.1 months and 3.3 months, respectively. There were three adverse grade 3/4 events. Grade 1 neutropenia was reported in one patient. CONCLUSION: Our data failed to demonstrate efficacy of a 4-weekly docetaxel regimen, in elderly patients with a poor performance status. However, incidence of side effects, including neutropenia, was lower than with a 3-week docetaxel regimen, as previously reported.
Aged
;
Appointments and Schedules
;
Carcinoma, Non-Small-Cell Lung
;
Carcinoma, Squamous Cell
;
Clinical Study
;
Disease-Free Survival
;
Drug Therapy
;
Epithelial Cells
;
Humans
;
Incidence
;
Lung Neoplasms
;
Lung
;
Neutropenia
;
Treatment Outcome
9.Effect of intraoperative neuromonitoring on efficacy and safety using sugammadex in thyroid surgery: randomized clinical trial
Mehmet Emin GUNES ; Ahmet Cem DURAL ; Cevher AKARSU ; Deniz GUZEY ; Nuri Alper SAHBAZ ; Evrim Kucur TULUBAS ; Sezer BULUT ; Turgut DONMEZ
Annals of Surgical Treatment and Research 2019;97(6):282-290
PURPOSE: The use of nondepolarizing neuromuscular blocking agents (NMBAs) may affect intraoperative neuromonitoring (IONM) during anesthesia used during thyroid and parathyroid surgery. METHODS: The use of sugammadex was evaluated in a prospective clinical study during thyroid surgery. Between July 2018 and January 2019, 129 patients were prospectively randomized to either the sugammadex group (group B) or the control group (group A). Group A patients underwent standardized IONM during thyroidectomy, while group B patients used an NMBA-reversal protocol comprised of rocuronium (0.6 mg/kg) in anesthesia induction and sugammadex (2 mg/kg) after first vagal stimulation (V0). A peripheral nerve stimulator was used to monitor the neuromuscular transmission. RESULTS: In our clinical study, it took 26.07 ± 3.26 and 50.0 ± 8.46 minutes to reach 100% recovery of laryngeal electromyography at injection of the sugammadex group (2 mg/kg) and the control group, respectively (P < 0.001). The train-of-four ratio recovered from 0 to >0.9 within 4 minutes after administering 2 mg/kg of sugammadex at the beginning of resection. Surgery time was significantly shorter in group B than in group A (P < 0.001). Transient recurrent laryngeal nerve (RLN) paralysis was detected in 4 patients from group A and in 3 patients from group B (P = 0.681). There was no permanent RLN paralysis in the 2 groups. CONCLUSION: Our clinical study showed that sugammadex effectively and rapidly improved the inhibition of neuromuscular function induced by rocuronium. The implementation of the nondepolarizing neuromuscular block recovery protocol may lead to tracheal intubation as well as favorable conditions for IONM in thyroid surgery.
Anesthesia
;
Clinical Study
;
Electromyography
;
Humans
;
Intubation
;
Neuromuscular Blockade
;
Neuromuscular Blocking Agents
;
Paralysis
;
Peripheral Nerves
;
Prospective Studies
;
Recurrent Laryngeal Nerve
;
Thyroid Gland
;
Thyroidectomy
10.Neurological Recovery Pattern in Cervical Spondylotic Myelopathy after Anterior Surgery: A Prospective Study with Literature Review
Naveen PANDITA ; Sanjeev GUPTA ; Prince RAINA ; Abhishek SRIVASTAVA ; Aamir Yaqoob HAKAK ; Omeshwar SINGH ; Mohd Azhar ud din DAROKHAN ; Mohd Farooq BUTT
Asian Spine Journal 2019;13(3):423-431
STUDY DESIGN: Prospective clinical study. PURPOSE: The present study aimed to examine the neurological recovery pattern in cervical spondylotic myelopathy (CSM) after anterior cervical decompression and compare it with the existing reports in the literature. OVERVIEW OF LITERATURE: Neurological recovery and regression of myelopathy symptoms is an important factor that determines the outcomes of surgical decompression. The present findings contribute to the literature on the pattern of neurological recovery and patient prognosis with respect to the resolution of myelopathy symptoms after surgery. METHODS: This prospective study was conducted in Government Medical College in Jammu, North India between November 2012 and October 2014, a total of 30 consecutive patients with CSM were included and treated with anterior decompression and stabilization. They were prospectively followed up for 1 year and were evaluated for their neurological recovery pattern. The postoperative outcome was evaluated using the modified Japanese Orthopaedic Association (mJOA) score. The recovery rate was calculated using Hirabayashi's method. The JOA score was assessed before the operation and postoperatively at 1 week, 2 weeks, 1 month, 3 months, 4 months, 6 months, and 1 year. RESULTS: The postoperative mJOA score was 0 in the 1st month, 12.90±3.57 in the 3rd month, 13.50±3.55 in the 4th month, 14.63±3.62 in the 6th month, and 14.9±3.24 at the final follow-up of 1 year. The average recovery rate during the 1st month follow-up was 0%, and that during the 3rd month follow-up was 12.91% with a range of 0%–50%. The average recovery rate during the 4th month was 32.5%, with a range of 0%–60%, while that during the 6th month was 72.83%, with a range of 0%–100%. The average recovery rate during the final follow-up of 1 year was 54.3%. CONCLUSIONS: Neurological recovery after surgical decompression starts from the 3rd postoperative month and progresses until the 6th postoperative month; thereafter, it gradually plateaus over the subsequent 6 months until it steadies. Symptom duration is an important factor that requires consideration while determining postoperative neurological recovery.
Asian Continental Ancestry Group
;
Clinical Study
;
Decompression
;
Decompression, Surgical
;
Follow-Up Studies
;
Humans
;
India
;
Methods
;
Prognosis
;
Prospective Studies
;
Spinal Cord Diseases


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