This is a case of monomorphic epitheliotropic intestinal T cell lymphoma presenting as ruptured viscous in a 64-year-old male. Monotonous cells were seen to infiltrate the full thickness of the bowel with immunoreactivity for CD3, CD8, CD56, CD68 and Granzyme B. The patient subsequently presented with maxillary and alveolar mass with similar immunohistomorphologic findings, suggesting metastasis. This rare disease has poor prognosis thus further reports should be conducted to profile this type of tumor.

Human

An elderly Filipino female presented with a 5-year enlarging left nasolacrimal mass initially diagnosed as Inverted Papilloma of the Lacrimal Sac. Repeat biopsy revealed a papillomatous neoplasm with thick and thin papillae, solid invaginating lobules, and anastomosing trabeculae of monomorphic squamotransitional cells, briskly infiltrated by neutrophils. Mucocytes, respiratory epithelium, and microcysts, typical of Inverting Sinonasal Papilloma, are absent. Immunohistochemistry, including a validated AFF2 IHC, confirmed the diagnosis of DEK::AFF2 sinonasal carcinoma. Awareness of this emerging entity is essential to prevent misdiagnosis and prompt surgical management.

Human ; Carcinoma, Squamous Cell ; Philippines