Myotonic dystrophy type 1 (DM1) is a rare hereditary disease characterized by myotonic and myasthenia,which can affect multiple systems throughout the body. In order to improve the understanding of the nervous system involvement of DM1,we report a case of DM1 with mild central nervous system symptoms and obvious cerebral white matter lesions in brain imaging. The patient was a 48-year-old male,primarily presenting with muscle weakness and atrophy,accompanied by slight memory decline. The level of creatine kinase was increased;electromyography showed myogenic changes and myotonic potential and magnetic resonance imaging showed multiple white matter lesions. The diagnosis of DM1 was comfirmed by genetic testing. The patient was treated with neurotrophic and cognitive-improving drugs and was followed up for 1 year with a stable condition.

Myotonic dystrophy type 1 (DM1) is a rare hereditary disease characterized by myotonic and myasthenia,which can affect multiple systems throughout the body. In order to improve the understanding of the nervous system involvement of DM1,we report a case of DM1 with mild central nervous system symptoms and obvious cerebral white matter lesions in brain imaging. The patient was a 48-year-old male,primarily presenting with muscle weakness and atrophy,accompanied by slight memory decline. The level of creatine kinase was increased;electromyography showed myogenic changes and myotonic potential and magnetic resonance imaging showed multiple white matter lesions. The diagnosis of DM1 was comfirmed by genetic testing. The patient was treated with neurotrophic and cognitive-improving drugs and was followed up for 1 year with a stable condition.

Objective The sirolimus-eluting stent (SES) has dramatically reduced the rate ofrestenosis in comparison to that with the bare-metal stent (BMS).This study aimed to evaluate the short-term efficacy and safety of Firebird stent implantation for patients with coronary heart disease (CHD). Methods From Apri12006 through July 2007, 155 patients (mean age 58.93～10.27 years) with CHD were implanted with Firebird stent or Cypher select stent at Daxing Hospital. Patients were followed up for one year. All-cause mortality, major adverse cardiac events (MACE, including cardiac death, myocardial infarction, recurrence of angina pectoris, heart failure, revascularization, and adverse arrhythmia) and stent thrombosis were compared between the 2 groups. Results Of the 155 consecutive patients, 147 patients were revascularized completely. Of these patients, 48 (with 59 lesions) were treated with Firebird stent, 59 patients (with 75 lesions) with Cypher select stent. The demographic characteristics were similar in the 2 groups. All the angiographic and procedural results were not significantly different between the 2 groups. All-cause mortality, myocardial infarction, recurrence of angina pectoris, MACE and stent thrombosis were almost identical between the 2 groups before discharge, at 6 months and at one year .Conclusion The short-term efficacy and safety of Firebird stent are similar to that of the cypher select stent for the treatment of patients with CHD.

OBJECTIVE Deep sternal wound infection (DSWI) is one of the most serious complications after the open heart cardiac surgery. To explore the risk factors and appropriate treatment methods,we performed this study retrospectively. METHODS Between Jan 2001 and Jan 2006,1123 patients underwent various cardiac surgical procedures via a median sternotomy in the Cardiovascular Center of Beijing Tongren Hospital. These patients were divided into two groups by whether suffered from DSWI. Univariate analyses were performed for possible risk factors,and Logistic regression was used in multivariate analysis. RESULTS Eight among 1123 (0.71%) patients suffered from DSWI. No one died from wound infection. Results from both single variate analysis and multivariate analysis showed that only age significantly associated with DSWI. No other independent risk factors significantly associated with DSWI. Blood culture in acute DSWI group tended to be positive,while in chronic group it tended to be negative. All patients with DSWI were effectively cured. CONCLUSIONS Age is an independent risk factor for DSWI. Early debridement with closed chest catheter irrigation and antibiotics using are strongly recommended as an easy and effective way to treat DWSI. Large-scale multicenter studies are still needed to determine reliable risk factors for DSWI.