Ischemic heart disease (IHD) is associated with high morbidity and mortality rates. Reperfusion therapy is the best treatment option for this condition. However, reperfusion can aggravate myocardial damage through a phenomenon known as myocardial ischemia/reperfusion (I/R) injury, which has recently gained the attention of researchers. Several studies have shown that Chinese herbal medicines and their natural monomeric components exert therapeutic effects against I/R injury. This review outlines the current knowledge on the pathological mechanisms through which mitochondria participate in I/R injury, focusing on the issues related to energy metabolism, mitochondrial quality control disorders, oxidative stress, and calcium. The mechanisms by which mitochondria mediate cell death have also been discussed. To develop a resource for the prevention and management of clinical myocardial I/R damage, we compiled the most recent research on the effects of Chinese herbal remedies and their monomer components.

Ischemic heart disease(IHD)is associated with high morbidity and mortality rates.Reperfusion therapy is the best treatment option for this condition.However,reperfusion can aggravate myocardial damage through a phenomenon known as myocardial ischemia/reperfusion(I/R)injury,which has recently gained the attention of researchers.Several studies have shown that Chinese herbal medicines and their natural monomeric components exert therapeutic effects against I/R injury.This review outlines the current knowledge on the pathological mechanisms through which mitochondria participate in I/R injury,focusing on the issues related to energy metabolism,mitochondrial quality control disorders,oxidative stress,and calcium.The mechanisms by which mitochondria mediate cell death have also been discussed.To develop a resource for the prevention and management of clinical myocardial I/R damage,we compiled the most recent research on the effects of Chinese herbal remedies and their monomer components.

Objective To analyze the clinical characteristics of children with Chikungunya fever(CHIKF),and provide basis for the treatment and prevention of CHIKF in children.Methods Medical records of children under 14 years old with CHIKF admitted to Foshan Shunde District Le Cong Hospital from July 12 to August 17,2025 were analyzed retrospectively.Epidemiological data,clinical characteristics,laboratory testing results,treatment methods of children were obtained through reviewing electronic health records.Results A total of 343 children confirmed with CHIKF were included in the analysis,all of whom resided in Foshan City,Guangdong Province.198 were males(57.73％)and 145 were females(42.27％).The average age of children was(8.6+3.3)years old.The main initial symptoms were fever(n=302,88.05％),rash(n=306,89.21％),and joint pain(n=246,71.72％).The initial laboratory testing results after admission showed that 95 cases(27.70％)had abnormal white blood cell count in blood routine,3 cases(0.87％)had decreased platelets,52 cases(15.16％)had increased C-reactive pro-tein,and 87 cases(25.36％)reported Chikungunya virus nucleic acid CT values.All children were discharged after completing a 7-day quarantine or Chikungunya virus nucleic acid testing result turned negative,with no severe ill-ness or death.Conclusion All cases from this epidemic experienced mild CHIKF.Early detection,early diagnosis,and early treatment are beneficial for reducing the occurrence of complications,and all children have good prog-noses.

Objective To analyze the clinical characteristics of children with Chikungunya fever(CHIKF),and provide basis for the treatment and prevention of CHIKF in children.Methods Medical records of children under 14 years old with CHIKF admitted to Foshan Shunde District Le Cong Hospital from July 12 to August 17,2025 were analyzed retrospectively.Epidemiological data,clinical characteristics,laboratory testing results,treatment methods of children were obtained through reviewing electronic health records.Results A total of 343 children confirmed with CHIKF were included in the analysis,all of whom resided in Foshan City,Guangdong Province.198 were males(57.73％)and 145 were females(42.27％).The average age of children was(8.6+3.3)years old.The main initial symptoms were fever(n=302,88.05％),rash(n=306,89.21％),and joint pain(n=246,71.72％).The initial laboratory testing results after admission showed that 95 cases(27.70％)had abnormal white blood cell count in blood routine,3 cases(0.87％)had decreased platelets,52 cases(15.16％)had increased C-reactive pro-tein,and 87 cases(25.36％)reported Chikungunya virus nucleic acid CT values.All children were discharged after completing a 7-day quarantine or Chikungunya virus nucleic acid testing result turned negative,with no severe ill-ness or death.Conclusion All cases from this epidemic experienced mild CHIKF.Early detection,early diagnosis,and early treatment are beneficial for reducing the occurrence of complications,and all children have good prog-noses.