Objective:To summarize and analyze the clinical characteristics of patients with Crohn′s disease (CD) complicated with small intestinal cancer (SBC) .Methods:Clinical data of patients with CD complicated with SBC treated in Sir Run Run Shaw Hospital of Zhejiang University School of Medicine from May 2018 to September 2022 were collected and analyzed retrospectively, including general data, clinical features (lesion location, disease behavior and complications, etc.), CD-related history, tumor features, diagnosis, treatment and prognosis. The cases of CD complicated with SBC published in PubMed database up to March 2022 were searched, and the literatures were reviewed and summarized.Results:There were 7 patients with CD complicated with SBC in our hospital, including 5 males and 2 females. Of the 7 patients, 6 patients were small intestinal adenocarcinoma and 1 patient was high-grade intraepithelial neoplasia. All the lesions involved ileum with stenosis. Tumors in only 2 cases of tumors were found by imaging examination. Before the diagnosis of SBC, the drugs and duration of CD-related treatment were different in 7 patients. SBC was mainly treated by surgery, supplemented by chemotherapy and CD-related treatment. No tumor recurrence was found in 5 patients after treatment, 1 patient had tumor recurrence 7 months after operation, and suspected tumor recurrence 3 years after the second operation. One patient ws lost during follow-up. Seven literatures were retrieved.Conclusion:Most of the patients with CD complicated with PBC are male, and ileal involvement is more common. Small intestinal adenocarcinoma and lymphoma are the most common tumor types. The ability of imaging examination to detect CD-SBC is limited.

Objective:To summarize and analyze the clinical characteristics of patients with Crohn′s disease (CD) complicated with small intestinal cancer (SBC) .Methods:Clinical data of patients with CD complicated with SBC treated in Sir Run Run Shaw Hospital of Zhejiang University School of Medicine from May 2018 to September 2022 were collected and analyzed retrospectively, including general data, clinical features (lesion location, disease behavior and complications, etc.), CD-related history, tumor features, diagnosis, treatment and prognosis. The cases of CD complicated with SBC published in PubMed database up to March 2022 were searched, and the literatures were reviewed and summarized.Results:There were 7 patients with CD complicated with SBC in our hospital, including 5 males and 2 females. Of the 7 patients, 6 patients were small intestinal adenocarcinoma and 1 patient was high-grade intraepithelial neoplasia. All the lesions involved ileum with stenosis. Tumors in only 2 cases of tumors were found by imaging examination. Before the diagnosis of SBC, the drugs and duration of CD-related treatment were different in 7 patients. SBC was mainly treated by surgery, supplemented by chemotherapy and CD-related treatment. No tumor recurrence was found in 5 patients after treatment, 1 patient had tumor recurrence 7 months after operation, and suspected tumor recurrence 3 years after the second operation. One patient ws lost during follow-up. Seven literatures were retrieved.Conclusion:Most of the patients with CD complicated with PBC are male, and ileal involvement is more common. Small intestinal adenocarcinoma and lymphoma are the most common tumor types. The ability of imaging examination to detect CD-SBC is limited.