Dihydromyricetin(DMY),a flavonoid compound extracted from Ampelopsis grossedentata,exhibits diverse pharmacological activities,including anti-inflammatory,antioxidant,antitumor,neuroprotective,and immuno-modulatory effects.Recent studies have demonstrated that DMY can suppress inflammatory responses and oxidative stress through multiple molecular pathways,as well as regulate bile acid metabolism and maintain intestinal microbiota balance.These actions help reduce histopathological damage,improve gastrointestinal barrier function,and alleviate the symptoms of digestive system diseases.DMY has shown significant therapeutic effects in the treatment of gastrointestinal inflamma-tion,liver diseases,and digestive tract tumors.This review systematically summarizes the mechanisms of action and thera-peutic potential of DMY in digestive system diseases,providing a scientific basis and theoretical support for its clinical ap-plication and the development of new drugs.

Dihydromyricetin(DMY),a flavonoid compound extracted from Ampelopsis grossedentata,exhibits diverse pharmacological activities,including anti-inflammatory,antioxidant,antitumor,neuroprotective,and immuno-modulatory effects.Recent studies have demonstrated that DMY can suppress inflammatory responses and oxidative stress through multiple molecular pathways,as well as regulate bile acid metabolism and maintain intestinal microbiota balance.These actions help reduce histopathological damage,improve gastrointestinal barrier function,and alleviate the symptoms of digestive system diseases.DMY has shown significant therapeutic effects in the treatment of gastrointestinal inflamma-tion,liver diseases,and digestive tract tumors.This review systematically summarizes the mechanisms of action and thera-peutic potential of DMY in digestive system diseases,providing a scientific basis and theoretical support for its clinical ap-plication and the development of new drugs.