Objective To investigate the interaction between homocysteine (HCY) and uric acid (UA) on the atherosclerosis (AS) of the fishing crew.Methods Research data were recruited from the special AS survey of 3 671 fishing workers (＞ 35 years old)of 11 large fishing companies,who had health checks from December 2014 to December 2016.Levels of homocysteine (HCY),uric acid (UA),carotid artery intimamedia thickness (CIMT) and carotid femoral pulse wave velocity (cfPWV) were detected in the 3 081 eligible subjects.According to the detected HCY and UA data,they were divided into 4 groups:the HCY and UA normal group (or the control group,n =1 486),the HCY high and UA normal group (or the HHCY group,n =979),the normal HCY and high UA group (or the HUA,n =370) and the increased HCY and UA group (or the HHCY group,n =979).The interaction of AS was assessed with 2 × 2 factorial analysis.Results Compared with those of the control group[(1.23 ±0.30) mm,(10.45 ±0.86) m/s],the levels of CIMT [(1.32±0.28),(1.30±0.30),(1.49 ±0.24) mm] and cfPWV[(10.63±0.99),(10.81 ±1.11),(11.40 ± 1.36) m/s] in the HHCY,HUA and HHCY + HUA groups all significantly elevated,and statistical significance could be seen,when comparisons were made between them (P ＜ 0.05).Compared with those of the HHCY group,the level of cfPWV in the HUA group and the level of CIMT in the HHCY + HUA group were significantly increased (P ＜ 0.05).In comparison with those of the HUA group,the levels of CIMT and cfPWV in the HHCY + HUA group all significantly elevated (P ＜ 0.05).The levels of HCY and UA were positively correlated with the levels of CIMT (r =0.375,r =0.285) and cfPWV (r =-0.342,r =0.399) (P ＜ 0.01).After correction of the confounding factors,HCY and UA were all independent factors of CIMT and cfPWV.The results of the 2 × 2 factorial analysis showed that HCY and UA had significant synergistic effect on IMT and cfPWV (P ＜ 0.01).Conclusions Both HCY and UA were independent influential factors of AS in fishing workers,and at the same time,they displayed synergistic interaction.

Objective To investigate the interaction between homocysteine (HCY) and uric acid (UA) on the atherosclerosis (AS) of the fishing crew.Methods Research data were recruited from the special AS survey of 3 671 fishing workers (＞ 35 years old)of 11 large fishing companies,who had health checks from December 2014 to December 2016.Levels of homocysteine (HCY),uric acid (UA),carotid artery intimamedia thickness (CIMT) and carotid femoral pulse wave velocity (cfPWV) were detected in the 3 081 eligible subjects.According to the detected HCY and UA data,they were divided into 4 groups:the HCY and UA normal group (or the control group,n =1 486),the HCY high and UA normal group (or the HHCY group,n =979),the normal HCY and high UA group (or the HUA,n =370) and the increased HCY and UA group (or the HHCY group,n =979).The interaction of AS was assessed with 2 × 2 factorial analysis.Results Compared with those of the control group[(1.23 ±0.30) mm,(10.45 ±0.86) m/s],the levels of CIMT [(1.32±0.28),(1.30±0.30),(1.49 ±0.24) mm] and cfPWV[(10.63±0.99),(10.81 ±1.11),(11.40 ± 1.36) m/s] in the HHCY,HUA and HHCY + HUA groups all significantly elevated,and statistical significance could be seen,when comparisons were made between them (P ＜ 0.05).Compared with those of the HHCY group,the level of cfPWV in the HUA group and the level of CIMT in the HHCY + HUA group were significantly increased (P ＜ 0.05).In comparison with those of the HUA group,the levels of CIMT and cfPWV in the HHCY + HUA group all significantly elevated (P ＜ 0.05).The levels of HCY and UA were positively correlated with the levels of CIMT (r =0.375,r =0.285) and cfPWV (r =-0.342,r =0.399) (P ＜ 0.01).After correction of the confounding factors,HCY and UA were all independent factors of CIMT and cfPWV.The results of the 2 × 2 factorial analysis showed that HCY and UA had significant synergistic effect on IMT and cfPWV (P ＜ 0.01).Conclusions Both HCY and UA were independent influential factors of AS in fishing workers,and at the same time,they displayed synergistic interaction.