Objective To analyse the hotspots and trends in research of patient navigation. Methods Literature on patient navigation were retrieved from China National Knowledge Infrastructure (CNKI) and Web of Science Core Collection from 1 January,2000 to 31 December,2023. CiteSpace 6.1.R6 was used to analyse the co-citation literature,institutions and key words. Results A total of 483 articles were included,covering 444 in English and 39 in Chinese. The overall number of annual publications showed a fluctuating upward trend. Domestic research started later than abroad. The research hotspots included navigation model,navigation nurse,breast cancer and social service. The development of navigation model,training of navigation nurses,and identification of standardised navigation outcome indicators are expected to become the trend in future research. Conclusion Domestic research in patient navigation is at a preliminary stage. It is recommended that researchers should learn from foreign studies by strengthen communications and cooperation,further explore and improve theories,and develop a scientific and localised patient navigation model and a training system for navigation nursing talents.

Objective To analyse the hotspots and trends in research of patient navigation. Methods Literature on patient navigation were retrieved from China National Knowledge Infrastructure (CNKI) and Web of Science Core Collection from 1 January,2000 to 31 December,2023. CiteSpace 6.1.R6 was used to analyse the co-citation literature,institutions and key words. Results A total of 483 articles were included,covering 444 in English and 39 in Chinese. The overall number of annual publications showed a fluctuating upward trend. Domestic research started later than abroad. The research hotspots included navigation model,navigation nurse,breast cancer and social service. The development of navigation model,training of navigation nurses,and identification of standardised navigation outcome indicators are expected to become the trend in future research. Conclusion Domestic research in patient navigation is at a preliminary stage. It is recommended that researchers should learn from foreign studies by strengthen communications and cooperation,further explore and improve theories,and develop a scientific and localised patient navigation model and a training system for navigation nursing talents.

ObjectiveTo study the effect of low molecular weight heparin sodium (LMWHS) therapy for exertional heat stroke (EHS) patients with pre-disseminated intravascular coagulation (pre-DIC).Methods A prospective randomized controlled trial (RCT) was conducted. Thirty-six patients with EHS with pre-DIC admitted to Department of Critical Care Medicine of 180th Hospital of Chinese PLA from April 2012 to November 2014 were divided into heparin sodium group (n = 20) and LMWHS group (n = 16) in accordance with the random number table. All patients received bundle treatment after being admitted to the hospital, including rapid cooling, fluid resuscitation, organ support (mechanical ventilation, hemopurification if necessary), supplement of pro-coagulation factors, etc. The patients in heparin sodium group were treated with continuous heparin sodium 12 500 U throughout 24 hours with intravenous pump for 5 days, and the patients in LMWHS group were given LMWHS 2 500 U subcutaneously, twice a day for 5 days.The incidence of DIC, incidence of bleeding and mortality of two groups were compared.The platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fib) and D-dimer of each patient between pre and post treatment times were compared.Results No significant difference was found in the incidence of DIC and mortality between LMWHS group and heparin sodium group (31.2% vs. 30.0%,χ2 =0.007,P = 0.936; 6.2% vs. 5.0%,χ2 = 0.026,P = 0.871). Incidence of bleeding during treatment in LMWHS group was significantly lower than that in heparin sodium group (12.5% vs. 45.0%,χ2 = 4.425,P = 0.035). After treatment,PLT in both LMWHS group and heparin sodium group was significantly increased compared with that before treatment (×109/L: 140.5±17.5 vs. 110.5±16.5, 152.6±21.5 vs. 120.0±20.0, bothP< 0.05) and D-dimer was significantly decreased (mg/L: 0.5±0.1 vs. 3.2±1.2, 0.6±0.2 vs. 4.4±1.8, bothP< 0.05). APTT after treatment in heparin sodium group was significantly prolonged compared with that before treatment (s: 75.3±10.6 vs. 44.1±8.2,P< 0.05) while no change in APTT was found in LMWHS group (s: 38.6±5.5 vs. 42.1±8.4,P> 0.05). No significant difference was found in PT and Fib between pre and post treatment in all the patients.Conclusion When LMWHS was applied in EHS patients in pre-DIC stage, it could not only prevent DIC as efficiently as heparin sodium, but also results in lower incidence of bleeding. So LMWHS is safer.