Ursodeoxycholic acid (UDCA) is a naturally occurring, low-toxicity, and hydrophilic bile acid (BA) in the human body that is converted by intestinal flora using primary BA. Solute carrier family 7 member 11 (SLC7A11) functions to uptake extracellular cystine in exchange for glutamate, and is highly expressed in a variety of human cancers. Retroperitoneal liposarcoma (RLPS) refers to liposarcoma originating from the retroperitoneal area. Lipidomics analysis revealed that UDCA was one of the most significantly downregulated metabolites in sera of RLPS patients compared with healthy subjects. The augmentation of UDCA concentration (≥25 μg/mL) demonstrated a suppressive effect on the proliferation of liposarcoma cells. [¹⁵N₂]-cystine and [¹³C₅]-glutamine isotope tracing revealed that UDCA impairs cystine uptake and glutathione (GSH) synthesis. Mechanistically, UDCA binds to the cystine transporter SLC7A11 to inhibit cystine uptake and impair GSH de novo synthesis, leading to reactive oxygen species (ROS) accumulation and mitochondrial oxidative damage. Furthermore, UDCA can promote the anti-cancer effects of ferroptosis inducers (Erastin, RSL3), the murine double minute 2 (MDM2) inhibitors (Nutlin 3a, RG7112), cyclin dependent kinase 4 (CDK4) inhibitor (Abemaciclib), and glutaminase inhibitor (CB839). Together, UDCA functions as a cystine exchange factor that binds to SLC7A11 for antitumor activity, and SLC7A11 is not only a new transporter for BA but also a clinically applicable target for UDCA. More importantly, in combination with other antitumor chemotherapy or physiotherapy treatments, UDCA may provide effective and promising treatment strategies for RLPS or other types of tumors in a ROS-dependent manner.

Objective To compare the therapeutic outcomes between laparoscopic radical Rephrectomy and open radical nephrectomy for renal cancer. Methods A prospective randomized controlled trial was performed in Fujian Provincial Tumor Hospital from January 2006 to July 2009.Sixty-two cases were randomly divided into 2 groups:laparoscopic radical nephrectomy and open radical nephrectomy.Primary outcome(post-operative hospital stay)and second outcome(estimated blood loss,operative time,incision length,post-operative complications,recurrence,metastasis and survival)were compared between 2 groups. Results Post-operative hospital stay was(5.4±1.3)d in laparoscopic group and(8.1±2.2)d in open group(P<0.05).Median estimated blood loss was 100 ml in laparoseopic group and 200 ml in open group(P<0.05).There were no significant difference between teh 2 groups in operative time,post-operative complications,recurrence,metastasis and survival rates(P>0.05). Conclusion Laparoscopic nephrectomy could reduce hospital stay,which provides a minimally invasive approach for renal cancer.

20?10~9/L. This regimen was given for one course for induction, and was followed by conventional chemotherapy as maintenance or consolidation when complete remission(CR) achieved, or succeeding with other treatment when no response could be observed. Results Six patients achieved CR (54.5%) and one achieved partial remission (PR)(9.1%) with one course of treatment. Among 6 of 11 patients with CR, 5 relapsed at 2,3,6,8 and 16 months respectively. Three relapsed patients were retreated with the same protocol but achieved only one partial responses. Nine of the 11 patients had been died and their mean survival (since induction chemotherapy) was 9.2 months. Infectious complications during cytopenia were less serious than conventional chemotherapy withno treatment-related.Conclusion This moderate intensity protocol with G-CSF priming is effective and safe but remissions are of short duration.

Objective To study the relationship between the expression of chemokines monocyte chemoattractant protein 1 (MCP 1) and the biological behavior of colorectal carcinoma by detecting chemokine mRNA and protein in human colorectal cancerous tissues. Methods The expression of the MCP 1 mRNA was detected in colorectal carcinoma collected freshly from surgical specimens by RT PCR and the expression of the MCP 1 protein was assessed in colorectal carcinoma tissues collected from surgical specimens by immunohistochemistry. Results All the 12 colorectal carcinoma expressed the MCP 1 mRNA, which was detected by RT PCR; MCP 1 protein was detected in 90% of the tumors; The expression of the MCP 1 protein in colorectal carcinoma was correlated with its state of metastasis and the Dukes' stage. Conclusions The expression of chemokine MCP 1 in colorectal carcinoma may influence its biological behaviour.

Objective To study the diagnosis and treatment of gastric stromal tumor(GST). Methods The clinical manifestation,pathological features ,diagnosis and treatment of 14 patients with GST were retrospectively analysed . Results Of the 14 GST,7 located in the fundus and the body of the stomach, 7 in the antrum of the stomach. The main symptom was abdominal pain, All the 14 GST were diagnosed by endoscopey, barium, ultrasound and CT. All patients were treated by excision. Histological diagnosis was as benign tumor in 8(57.1%)cases, uncertain types in 5 (35.7%)cases , and malignant tumor in 1 ( 7.1 %)case. There were local recurrence in 3 cases and death in 1 case after the operation. Conclusions The complete local excision is recommended for GST patients. Long term postoperative follow up is necessary for patients with GST. Reexcision may be helpful to the patients with recurrence or metastasis.