The evaluation of blood compatibility of biomaterials is crucial for ensuring the clinical safety of implantable medical devices. To address the limitations of traditional testing methods in real-time monitoring and electrical property analysis, this study developed a portable electrical impedance tomography (EIT) system. The system uses a 16-electrode design, operates within a frequency range of 1 to 500 kHz, achieves a signal to noise ratio (SNR) of 69.54 dB at 50 kHz, and has a data collection speed of 20 frames per second. Experimental results show that the EIT system developed in this study is highly consistent with a microplate reader ( R ²=0.97) in detecting the hemolytic behavior of industrial-grade titanium (TA3) and titanium alloy-titanium 6 aluminum 4 vanadium (TC4) in anticoagulated bovine blood. Additionally, with the support of a multimodal image fusion Gauss-Newton one-step iterative algorithm, the system can accurately locate and monitor in real-time the dynamic changes in blood permeation and coagulation caused by TC4 in vivo. In conclusion, the EIT system developed in this study provides a new and effective method for evaluating the blood compatibility of biomaterials.
Electric Impedance ; Animals ; Tomography/instrumentation* ; Biocompatible Materials ; Materials Testing/instrumentation* ; Cattle ; Titanium ; Alloys ; Prostheses and Implants

Abdominal obesity represents the predominant obesity phenotype in China.Compared to peripheral obesity,individuals with abdominal obesity are more prone to metabolic disorders,cardiovascular diseases,and higher mortality rates.Catgut embedding therapy at acupoints has demonstrated significant clinical efficacy in preventing and treating abdominal obesity.However,standardized clinical guidelines for its application in abdominal obesity management have not yet been established.This review comprehensively summarizes the clinical applications of catgut embedding therapy for simple abdominal obesity and abdominal obesity with various complications,aiming to provide clinical evidence and theoretical guidance for its use in preventing and treating abdominal obesity.

Objective:To retrieve, evaluate and summarize relevant evidence on communication strategies for families with perinatal loss, and to provide an evidence-based basis for communication practice among clinical health professionals.Methods:The system searches for evidence related to the loss of family doctor-patient communication strategies during the perinatal period in computer decision support systems such as UpToDate, BMJ Best Clinical Practice, International Guidelines Network, UK National Institute for Health and Clinical Excellence, PubMed, Web of Science, CINAHL, China National Knowledge Infrastructure, Wanfang Data, as well as in Chinese and English databases and related websites.The search was conducted between January 2012 and December 2022. The literature ′s quality and extracted evidence were independently evaluated by two researchers according to professional judgement. Results:A total of 13 articles were included, including 1 clinical decision, 2 guidelines, 4 national standards, 2 expert consensus, and 4 systematic reviews. 30 pieces of evidence have been summarized across five aspects, comprising communication environment, communication skills, timing and key points of communication, communication for special populations, and system-level communication support.Conclusions:This study summarizes the relevant evidence on communication strategies for family doctor-patient communication strategies for perinatal loss. Clinical professionals should carefully select and apply relevant evidence based on available medical resources and parental preferences, Develop and implement practical standards for family doctor-patient communication strategies for perinatal loss at the system level, further harmonize communication behaviors, and improve communication quality.

Objective:To retrieve, evaluate and summarize relevant evidence on communication strategies for families with perinatal loss, and to provide an evidence-based basis for communication practice among clinical health professionals.Methods:The system searches for evidence related to the loss of family doctor-patient communication strategies during the perinatal period in computer decision support systems such as UpToDate, BMJ Best Clinical Practice, International Guidelines Network, UK National Institute for Health and Clinical Excellence, PubMed, Web of Science, CINAHL, China National Knowledge Infrastructure, Wanfang Data, as well as in Chinese and English databases and related websites.The search was conducted between January 2012 and December 2022. The literature ′s quality and extracted evidence were independently evaluated by two researchers according to professional judgement. Results:A total of 13 articles were included, including 1 clinical decision, 2 guidelines, 4 national standards, 2 expert consensus, and 4 systematic reviews. 30 pieces of evidence have been summarized across five aspects, comprising communication environment, communication skills, timing and key points of communication, communication for special populations, and system-level communication support.Conclusions:This study summarizes the relevant evidence on communication strategies for family doctor-patient communication strategies for perinatal loss. Clinical professionals should carefully select and apply relevant evidence based on available medical resources and parental preferences, Develop and implement practical standards for family doctor-patient communication strategies for perinatal loss at the system level, further harmonize communication behaviors, and improve communication quality.

Objective:To explore the current status and the influencing factors of protracted postpartum urinary retention(P-PUR) in women with labor analgesia, so as to provide evidences for early diagnosis and timely intervention for P-PUR.Methods:A total of 41 995 women who were given vaginal delivery under labor analgesia from January 2017 to October 2020 in Women′s Hospital of Nanjing Medical University were chosen as the research objects. A retrospective analysis was performed for the clinical data of 62 women with P-PUR, and a 1∶4 matching case control study was conducted. Logistic regression analysis was used to analyze the variables with statistical difference in univariate analysis, so as to explore the independent influencing factors of P-PUR in women with labor analgesia.Results:Among 41 995 women with labor analgesia, 62 women suffered from P-PUR, and the incidence was about 0.15% (62/41 995). The Logistic regression model showed that nulliparity ( OR=121.80, 95% CI 8.59-1 727.40, P<0.05), forceps delivery ( OR=13.41, 95% CI 2.21-81.58, P<0.05),Ⅱdegree porineal iaceration ( OR=0.04, 95% CI 0.01-0.11, P<0.05), episiotomy ( OR=0.13, 95% CI 0.04-0.47, P<0.05) and perineotomy with perineal laceration ( OR=0.20, 95% CI 0.06-0.63, P<0.05) were the independent risk factors. Conclusions:For primiparas with labor analgesia, interventions should be taken to reduce perineal injury, and indications of forceps delivery should be strictly controlled, so as to reduce P-PUR and adverse urinary tract complications.

Objective:To investigate the effect of pressurization on the recovery of exercise-induced fatigue in rats in plateau environment.Methods:A total of 24 rats in natural environment were transported from altitude of 1 520 m to 2 260 m, then randomly divided into three groups: group A (quiet control group), group B (natural recovery group), and group C (pressurized recovery group), with 8 rats in each group. After the exercise fatigue model training on the running platform every day, the rats in the group B recovered naturally, while the rats in the group C had a 1-hour-recovery in a pressurized cabin of 0.2 MPa for 6 days. On the day 7, the rats in the group B and the group C exercised to exhaustion, and then were killed 24 hours later for sampling. The exercise time of exhaustion was recorded; gastrocnemius HIF-1α, lung iNOS, myocardial CaMKⅡ, and BNP protein expressions, and serum SOD, TAOC, GSH-Px and CAT, ROS, MDA concentration were determined; the morphological chages of myocardium after HE staining, and gastrocnemius were observed.Results:(1) The exhaustive exercise time of the group B (99.00±69.37 min) was lower than that of group C (126.14±59.09 min). (2)The expression level of HIF-1α protein in skeletal muscle was 0.220±0.170 in the group A, 0.070±0.003 in the group B, and 0.360±0.140 in the group C. The expression level of the group C was significantly higher than that in the group B ( P<0.05). The expression level of CaMKⅡ protein in myocardium was 1.18±0.17 in the group A, 1.07±0.13 in the group B, and 1.40±0.22 in the group C. There were no statistical difference between each group. The expression level of BNP protein in myocardium was 0.29±0.05 in the group A, 0.29±0.08 in the group B, 0.53±0.01 in the group C. There were significant differences comparing the group C with the group A and the group B respectively ( P<0.01). The expression level of iNOS in lung was 0.130±0.002 in the group A, 0.450±0.004 in the group B, and 0.360±0.005 in the group C. It was significantly lower in the group A than those in the group C and the group B ( P<0.01). (3) Compared with the group A, the serum SOD ( P<0.05) and GSH-Px decreased, ROS and MDA increased in the group B ( P<0.05). Compared with the group B, the serum SOD ( P<0.05), GSH-Px and TAOC increased, ROS and MDA decreased in the group C ( P<0.05). (4) Under light microscope, muscle fiber in the group B showed atrophy, thinning, rupture, increase of cell gap, and local lytic necrosis; while muscle fiber in the group C showed shrinking gap, decreased rupture, and relieved cell infiltration. Conclusion:In the plateau and hypoxia environment, the application of pressurization to the rats in exercise-induced fatigue can prolong the exhaustive exercise time, alleviate the morphological changes of muscle fibers in myocardium and skeletal muscles, e. g. thinning, rupture, and increase of cell gap, enhance the expressions of HIF-1α, CaMKⅡand BNP in gastrocnemius muscle, increase the levels of serum SOD, GSH Px, and TAOC, reduce the levels of serum ROS and MDA, and contribute to sports fatigue recovery.

Objective:To investigate the effect of pressurization on the recovery of exercise-induced fatigue in rats in plateau environment.Methods:A total of 24 rats in natural environment were transported from altitude of 1 520 m to 2 260 m, then randomly divided into three groups: group A (quiet control group), group B (natural recovery group), and group C (pressurized recovery group), with 8 rats in each group. After the exercise fatigue model training on the running platform every day, the rats in the group B recovered naturally, while the rats in the group C had a 1-hour-recovery in a pressurized cabin of 0.2 MPa for 6 days. On the day 7, the rats in the group B and the group C exercised to exhaustion, and then were killed 24 hours later for sampling. The exercise time of exhaustion was recorded; gastrocnemius HIF-1α, lung iNOS, myocardial CaMKⅡ, and BNP protein expressions, and serum SOD, TAOC, GSH-Px and CAT, ROS, MDA concentration were determined; the morphological chages of myocardium after HE staining, and gastrocnemius were observed.Results:(1) The exhaustive exercise time of the group B (99.00±69.37 min) was lower than that of group C (126.14±59.09 min). (2)The expression level of HIF-1α protein in skeletal muscle was 0.220±0.170 in the group A, 0.070±0.003 in the group B, and 0.360±0.140 in the group C. The expression level of the group C was significantly higher than that in the group B ( P<0.05). The expression level of CaMKⅡ protein in myocardium was 1.18±0.17 in the group A, 1.07±0.13 in the group B, and 1.40±0.22 in the group C. There were no statistical difference between each group. The expression level of BNP protein in myocardium was 0.29±0.05 in the group A, 0.29±0.08 in the group B, 0.53±0.01 in the group C. There were significant differences comparing the group C with the group A and the group B respectively ( P<0.01). The expression level of iNOS in lung was 0.130±0.002 in the group A, 0.450±0.004 in the group B, and 0.360±0.005 in the group C. It was significantly lower in the group A than those in the group C and the group B ( P<0.01). (3) Compared with the group A, the serum SOD ( P<0.05) and GSH-Px decreased, ROS and MDA increased in the group B ( P<0.05). Compared with the group B, the serum SOD ( P<0.05), GSH-Px and TAOC increased, ROS and MDA decreased in the group C ( P<0.05). (4) Under light microscope, muscle fiber in the group B showed atrophy, thinning, rupture, increase of cell gap, and local lytic necrosis; while muscle fiber in the group C showed shrinking gap, decreased rupture, and relieved cell infiltration. Conclusion:In the plateau and hypoxia environment, the application of pressurization to the rats in exercise-induced fatigue can prolong the exhaustive exercise time, alleviate the morphological changes of muscle fibers in myocardium and skeletal muscles, e. g. thinning, rupture, and increase of cell gap, enhance the expressions of HIF-1α, CaMKⅡand BNP in gastrocnemius muscle, increase the levels of serum SOD, GSH Px, and TAOC, reduce the levels of serum ROS and MDA, and contribute to sports fatigue recovery.