Autoimmune pancreatitis is a special type of chronic pancreatitis that can lead to abnormal pancreatic exocrine function in patients. Autoimmune pancreatitis comorbid with pancreatic exocrine insufficiency has a complex pathogenesis， and there is limited research on this topic， leading to the lack of understanding of such patients in clinical practice. This article introduces the epidemiology of autoimmune pancreatitis， briefly describes the pathogenesis of pancreatic exocrine insufficiency caused by autoimmune pancreatitis， and summarizes the various detection methods for pancreatic exocrine function， nutritional assessments， lifestyle management， and drug therapy， in order to strengthen the understanding of autoimmune pancreatitis comorbid with pancreatic exocrine insufficiency and improve the clinical diagnosis and treatment of pancreatic exocrine insufficiency.

Irritable bowel syndrome (IBS) is an extremely common chronic intestinal disorder characterized by recurrent abdominal pain and altered bowel habits, significantly impacting patients' quality of life. The etiology of IBS remains incompletely understood. Research has identified low-grade intestinal inflammation and immune activation, primarily manifested as an imbalance between pro-inflammatory and anti-inflammatory cytokines, as key pathogenic mechanisms in IBS. Among these, interleukin-6 (IL-6), a core pro-inflammatory cytokine, is significantly elevated in IBS patients. IL-6 contributes to the pathogenesis of IBS through various mechanisms, including altering individual susceptibility to IBS, promoting gastrointestinal motility and secretion, activating the hypothalamic-pituitary-adrenal axis, inducing visceral hypersensitivity, and impairing intestinal mucosal barrier function. Furthermore, IL-6 levels are closely associated with the severity of IBS symptoms. This review summarizes the role and mechanisms of IL-6 in IBS, aiming to provide insights and references for clinicians and researchers investigating the etiology of IBS.

Intravitreal injection of anti-vascular endothelial growth factor(VEGF)agents has become the primary treatment for macular edema associated with retinal vascular disease such as diabetic retinopathy and retinal vein occlusion, but there are limitations such as variable treatment efficacy and insufficient durability of therapeutic effects. As the first bispecific antibody applied in ophthalmic treatment, Faricimab achieves favorable outcomes by simultaneously targeting both VEGF-A and angiopoietin-2(Ang-2)pathways. Based on evidence from recent clinical trials and real-world studies, this article reviews the research progress on Faricimab for the treatment of diabetic macular edema(DME), retinal vein occlusion-associated macular edema(RVO-ME)and refractory macular edema compared to the therapeutic effects of other agents. Additionally, based on Faricimab's safety characteristics and future potential, its therapeutic prospects for macular edema associated with retinal vascular diseases are discussed. This review aims to provide evidence-based references for optimizing clinical treatment strategies, thereby contributing to mitigating the risk of vision loss due to macular edema.

To promote the standardization and normalization of perioperative care for follicular unit extraction(FUE) hair transplantation, ensure treatment efficacy, and align with advancements in the specialty, the Nursing Branch of the Chinese Association of Plastic and Aesthetics organized a panel of domestic experts. By integrating evidence-based medicine with clinical practice experience, and following thorough discussions, these experts developed the Clinical Practice Expert Consensus on Perioperative Nursing Care for Follicular Unit Extraction (2025). This consensus provides a comprehensive overview of hair transplantation, covering preoperative preparation, surgical procedures, intraoperative coordination, postoperative management, and complication prevention and treatment. It serves as a key reference and guide for implementing standardized perioperative nursing care in FUE hair transplantation.

Objective:The distribution and change characteristics of patients undergoing pelvic floor rehabilita-tion treatment were analyzed,the related influencing factors of patients with clinical symptoms and the characteris-tics of patients seeking treatment were preliminarily discussed.Methods:A retrospective analysis was conducted on the age,delivery mode,delivery times,treatment time and other data of patients(target population)who re-ceived pelvic floor rehabilitation treatment in the Third Affiliated Hospital of Guangzhou Medical University from January 2010 to December 2019.Results:①There were 3033 cases in the target population,72.8％(2209/3033)without clinical symptoms,showing a downward trend(P=0.000);The number of patients with clinical symptoms was 27.2％(824/3033),showing an increasing trend(P=0.000).Urinary incontinence accounted for 72.5％(597/824)of the eight categories.②In the past 10 years,the proportion of patients over 40 years old increased year by year(P=0.001).③The proportion of women giving birth through vagina was the highest(70.3％)and remained stable(P=0.054).④The proportion of first-time mothers was the highest(73.1％),and the number of patients with birth rate ≥2 showed an increasing trend(P=0.000);⑤84.8％(2573/3033)patients received pelvic floor rehabilitation treatment less than 1 year before the last delivery,and the treatment time more than 1 year before the last delivery showed an increasing trend(P=0.002,r=0.855).⑥Age ≥ 40 years old(OR 10.884,P＜0.001),3 pregnancies(OR 1.634,P=0.001),4 pregnancies(OR 1.908,P＜0.001),2 births(OR 1.305,P=0.038),3 births(OR 2.327,P=0.001),vaginal delivery(OR 2.079,P＜0.001)were risk factors for patients undergoing pelvic floor rehabilitation treatment.Conclusions:Urinary incontinence was the main symptom in patients with clinical symptoms after pelvic floor rehabilitation treatment,which showed an in-creasing trend.To strengthen early screening and intervention for women aged ≥40 years,with a history of vagi-nal delivery,≥3 times of pregnancy and≥2 times of birth,for women aged≥40 years and more than 1 year from the last delivery,the treatment time should be moved forward.

Objective:The distribution and change characteristics of patients undergoing pelvic floor rehabilita-tion treatment were analyzed,the related influencing factors of patients with clinical symptoms and the characteris-tics of patients seeking treatment were preliminarily discussed.Methods:A retrospective analysis was conducted on the age,delivery mode,delivery times,treatment time and other data of patients(target population)who re-ceived pelvic floor rehabilitation treatment in the Third Affiliated Hospital of Guangzhou Medical University from January 2010 to December 2019.Results:①There were 3033 cases in the target population,72.8％(2209/3033)without clinical symptoms,showing a downward trend(P=0.000);The number of patients with clinical symptoms was 27.2％(824/3033),showing an increasing trend(P=0.000).Urinary incontinence accounted for 72.5％(597/824)of the eight categories.②In the past 10 years,the proportion of patients over 40 years old increased year by year(P=0.001).③The proportion of women giving birth through vagina was the highest(70.3％)and remained stable(P=0.054).④The proportion of first-time mothers was the highest(73.1％),and the number of patients with birth rate ≥2 showed an increasing trend(P=0.000);⑤84.8％(2573/3033)patients received pelvic floor rehabilitation treatment less than 1 year before the last delivery,and the treatment time more than 1 year before the last delivery showed an increasing trend(P=0.002,r=0.855).⑥Age ≥ 40 years old(OR 10.884,P＜0.001),3 pregnancies(OR 1.634,P=0.001),4 pregnancies(OR 1.908,P＜0.001),2 births(OR 1.305,P=0.038),3 births(OR 2.327,P=0.001),vaginal delivery(OR 2.079,P＜0.001)were risk factors for patients undergoing pelvic floor rehabilitation treatment.Conclusions:Urinary incontinence was the main symptom in patients with clinical symptoms after pelvic floor rehabilitation treatment,which showed an in-creasing trend.To strengthen early screening and intervention for women aged ≥40 years,with a history of vagi-nal delivery,≥3 times of pregnancy and≥2 times of birth,for women aged≥40 years and more than 1 year from the last delivery,the treatment time should be moved forward.

Lung cancer is the malignant tumor with the highest incidence and mortality rate worldwide.For lung adenocarcinoma,identifying specific gene mutations,fusions,and giving corresponding targeted drugs can greatly improve the survival time of the patients.Among them,anaplastic lymphoma kinase(ALK)fusion occurs in 3％-7％of non-small cell lung cancer(NSCLC).In clinical practice,a variety of detection methods can be used to determine the ALK fusion status,but false negative test results are possible.This paper retrospectively analyzed the diagnosis and treatment of a patient with lung adeno-carcinoma,judged the ALK fusion status by various detection methods.Among them,immunohistochemistry(IHC)(Ventana D5F3),RNA based next-generation sequencing(RNA-based NGS)confirmed positive echinoderm microtubule associated protein like 4(EML4)-ALK fusion,while DNA-based NGS was negative.This paper analyzed the detection methods of ALK fusion,in order to clarify which detection method is the most accurate and simple to choose in different clinical cases and guide the subsequent treatment.

Objective To investigate the spatiotemporal distribution characteristics and potential influencing factors of newly diagnosed echinococcosis cases in Qinghai Province from 2016 to 2022, so as to provide insights into the formulation of the echinococcosis control strategy in Qinghai Province. Methods The number of individuals screened for echinococcosis, number of newly diagnosed echinococcosis cases, number of registered dogs and number of stray dogs were captured from the annual reports of echinococcosis control program in Qinghai Province from 2016 to 2022, and the detection of newly diagnosed echinococcosis cases was calculated. The number of populations, precipitation, temperature, wind speed, sunshine hours, average altitude, number of year-end cattle stock, number of year-end sheep stock, gross domestic product (GDP) per capita, and number of village health centers in each county (district) of Qinghai Province were captured from the Qinghai Provincial Statistical Yearbook, and county-level electronic maps in Qinghai Province were downloaded from the National Platform for Common Geospatial Information Services. The software ArcGIS 10.8 was used to map the distribution of newly diagnosed echinococcosis cases in Qinghai Province, and the spatial autocorrelation analysis of newly diagnosed echinococcosis cases was performed. In addition, the spacetime scan analyses of number of individuals screened for echinococcosis, number of newly diagnosed echinococcosis cases and geographical coordinates in Qinghai Province were performed with the software SaTScan 10.1.2, and the spatial stratified heterogeneity of the detection of newly diagnosed echinococcosis cases was investigated with the software GeoDetector. Results A total of 6 569 426 residents were screened for echinococcosis in Qinghai Province from 2016 to 2022, and 5 924 newly diagnosed echinococcosis cases were found. The detection of newly diagnosed echinococcosis cases appeared a tendency towards a decline over years from 2016 to 2022 (χ² = 11.107, P < 0.01), with the highest detection in Guoluo Tibetan Autonomous Prefecture in 2017 (82.12/10⁵). There were spatial clusters in the detection of newly diagnosed echinococcosis cases in Qinghai Province from 2016 to 2018 (Moran’s I = 0.34 to 0.65, all Z values > 1.96, all P values < 0.05), and the distribution of newly diagnosed echinococcosis cases appeared random distribution from 2019 to 2022 (Moran’s I = −0.09 to 0.04, all Z values < 1.96, all P values > 0.05). Local spatial autocorrelation analysis showed high-high clusters and low-low clusters in the detection of new diagnosed echinococcosis cases in Qinghai Province from 2016 to 2022, and space-time scan analysis showed that the first most likely cluster areas of newly diagnosed echinococcosis cases in Qinghai Province from 2016 to 2022 were mainly distributed in Yushu Tibetan Autonomous Prefecture and Guoluo Tibetan Autonomous Prefecture. GeoDetector-based analysis of the driving factors for the spatial stratified heterogeneity of detection of newly diagnosed echinococcosis cases in Qinghai Province showed that average altitude, number of village health centers, number of cattle and sheep stock, GDP per capita, annual average sunshine hours, and annual average temperature had a strong explanatory power for the spatial distribution of newly diagnosed echinococcosis cases, with q values of 0.630, 0.610, 0.600, 0.590, 0.588, 0.537 and 0.526, respectively. Conclusions The detection of newly diagnosed echinococcosis cases appeared a tendency towards a decline in Qinghai Province over years from 2016 to 2022, showing spatial clustering. Targeted control measures are required in cluster areas of newly diagnosed echinococcosis cases for further control of the disease.

Objective:The distribution and change characteristics of patients undergoing pelvic floor rehabilita-tion treatment were analyzed,the related influencing factors of patients with clinical symptoms and the characteris-tics of patients seeking treatment were preliminarily discussed.Methods:A retrospective analysis was conducted on the age,delivery mode,delivery times,treatment time and other data of patients(target population)who re-ceived pelvic floor rehabilitation treatment in the Third Affiliated Hospital of Guangzhou Medical University from January 2010 to December 2019.Results:①There were 3033 cases in the target population,72.8％(2209/3033)without clinical symptoms,showing a downward trend(P=0.000);The number of patients with clinical symptoms was 27.2％(824/3033),showing an increasing trend(P=0.000).Urinary incontinence accounted for 72.5％(597/824)of the eight categories.②In the past 10 years,the proportion of patients over 40 years old increased year by year(P=0.001).③The proportion of women giving birth through vagina was the highest(70.3％)and remained stable(P=0.054).④The proportion of first-time mothers was the highest(73.1％),and the number of patients with birth rate ≥2 showed an increasing trend(P=0.000);⑤84.8％(2573/3033)patients received pelvic floor rehabilitation treatment less than 1 year before the last delivery,and the treatment time more than 1 year before the last delivery showed an increasing trend(P=0.002,r=0.855).⑥Age ≥ 40 years old(OR 10.884,P＜0.001),3 pregnancies(OR 1.634,P=0.001),4 pregnancies(OR 1.908,P＜0.001),2 births(OR 1.305,P=0.038),3 births(OR 2.327,P=0.001),vaginal delivery(OR 2.079,P＜0.001)were risk factors for patients undergoing pelvic floor rehabilitation treatment.Conclusions:Urinary incontinence was the main symptom in patients with clinical symptoms after pelvic floor rehabilitation treatment,which showed an in-creasing trend.To strengthen early screening and intervention for women aged ≥40 years,with a history of vagi-nal delivery,≥3 times of pregnancy and≥2 times of birth,for women aged≥40 years and more than 1 year from the last delivery,the treatment time should be moved forward.