Microbiomes are known to have a beneficial effect on human health by promoting the effective removal of improperly functioning immune cells and protecting the host from pathogen infection. On the other hand, these microbiomes are also known as the causative agent of numerous malignant tumors. Until now, the bladder has been regarded as aseptic, but the concept of the “sterile bladder” has been changed with the discovery of living bacteria embedded in the bladder with the recent development of polymerase chain reaction and culture techniques. This paper referred to the relationship between microbiome and bladder cancer. Microbiome will be able to be seen as a non-invasive biomarker to predict the success rate of intravesical bacillus Calmette-Guerin instillation treatment in patients of bladder cancer.

Microbiomes are known to have a beneficial effect on human health by promoting the effective removal of improperly functioning immune cells and protecting the host from pathogen infection. On the other hand, these microbiomes are also known as the causative agent of numerous malignant tumors. Until now, the bladder has been regarded as aseptic, but the concept of the “sterile bladder” has been changed with the discovery of living bacteria embedded in the bladder with the recent development of polymerase chain reaction and culture techniques. This paper referred to the relationship between microbiome and bladder cancer. Microbiome will be able to be seen as a non-invasive biomarker to predict the success rate of intravesical bacillus Calmette-Guerin instillation treatment in patients of bladder cancer.

Purpose: Pneumococcal vaccination (13-valent pneumococcal conjugate vaccine [PCV13]) is recommended to cancer patients undergoing systemic chemotherapy. However, the optimal time interval between vaccine administration and initiation of chemotherapy has been little studied in adult patients with solid malignancies. Materials and Methods: We conducted a prospective randomized controlled trial to evaluate whether administering PCV13 on the first day of chemotherapy is non-inferior to vaccinating 2 weeks prior to chemotherapy initiation. Patients were randomly assigned to two study arms, and serum samples were collected at baseline and 4 weeks after vaccination to analyze the serologic response against Streptococcus pneumoniae using a multiplexed opsonophagocytic killingassay. Results: Of the 92 patients who underwent randomization, 43 patients in arm A (vaccination 2 weeks before chemotherapy) and 44 patients in arm B (vaccination on the first day of chemotherapy) were analyzed. Immunogenicity was assessed by geometric mean and fold-increase of post-vaccination titers, seroprotection rates (percentage of patients with post-vaccination titers > 1:64), and seroconversion rates (percentage of patients with > 4-fold increase in post-vaccination titers). Serologic responses to PCV13 did not differ significantly between the two study arms according to all three types of assessments. Conclusion The overall antibody response to PCV13 is adequate in patients with gastric and colorectal cancer during adjuvant chemotherapy, and no significant difference was found when patients were vaccinated two weeks before or on the day of chemotherapy initiation.

PURPOSE: As the importance of breastfeeding has been reinforced, human milk is often stored for practical reasons. Therefore, we evaluated optimal storage and processing methods for human milk from a nutritional standpoint. METHODS: Human milk samples were collected between June 2017 and February 2018. Also, data about maternal information were collected. Human milk was analyzed for macronutrients and caloric content. The samples were subdivided into groups for nutrient analysis. The control group (fresh milk) was not stored or processed. The other groups (9 groups) consisted of samples analyzed based on different storage temperatures (room temperature, refrigerated, frozen), defrosting methods (bottle warmer, room temperature thawing, microwave oven), and storage period (1 week, 1 month, 2 months) and compared with the control group. RESULTS: There was no statistically significant difference in the nutrient content of human milk among the collected samples. A significant change in the content of macronutrients in milk samples was observed under storage condition at different temperatures for 1 week with subsequent thawing with bottle warmer compared to fresh milk. Under storage at −20°C for 1 week with subsequent thawing with different defrosting methods, a significant change in the content of macronutrients in milk samples was observed compared to fresh milk. After storage at −20°C for different periods and thawing with a bottle warmer, a significant change in macronutrient content in milk samples was observed compared to fresh milk regardless of the storage period. CONCLUSION: Unlike previous guidelines, changes in macronutrient content in milk samples were observed regardless of the method of storing and thawing. Apparently, it is proposed that mothers should feed fresh human milk to their babies without storing.
Breast Feeding ; Humans ; Infant Formula ; Methods ; Microwaves ; Milk ; Milk, Human ; Mothers

Leaflet escape of prosthetic valve is rare but potentially life threatening. It is essential to make timely diagnosis in order to avoid mortality. Transesophageal echocardiography and cinefluoroscopy is usually diagnostic and the location of the missing leaflet can be identified by computed tomography (CT). Emergent surgical correction is mandatory. We report a case of fractured escape of Edward-Duromedics mitral valve 27 years after the surgery. The patient presented with symptoms of acute decompensated heart failure and cardiogenic shock. She was instantly intubated and mechanically ventilated. After prompt evaluation including transthoracic echocardiography and CT, the escape of the leaflet was confirmed. The patient underwent emergent surgery for replacement of the damaged prosthetic valves immediately. Eleven days after the surgery, the dislodged leaflet in iliac artery was removed safely and the patient recovered well.
Echocardiography, Transesophageal ; Heart Failure ; Heart Valve Prosthesis ; Humans ; Iliac Artery ; Mitral Valve ; Prosthesis Failure ; Shock, Cardiogenic ; United Nations

PURPOSE: The purpose of this study was to identify the effects of a Yoga-focused prenatal program on the stress, anxiety, self confidence and labor pain of pregnant women who had in vitro fertilization (IVF) treatment. METHODS: A quasi experimental study with a non-equivalent control group pretest-posttest design was used. The data collection period and meditation program were between January 9 and August 31, 2009. Forty-six women who were pregnant following IVF, and were between 12-20 weeks gestation, participated in the study (23 experimental group, 23 control group). Data were analyzed using Chi-square test, Mann-Whitney U Test, ANCOVA, and Cronbach's alpha coefficients with the SPSS 12.0 for Windows Program. RESULTS: Although the sample size was limited, women who participated in the program showed statistically significant improvements in stress, anxiety, labor pain, and labor confidence for women pregnant after IVF. CONCLUSION: The result indicate that this 12-week Yoga-focused educational program can be utilized for women pregnant following IVF to reduce their stress, anxiety, and labor pain, and to increase delivery confidence. It is suggested that the Yoga-focused educational program be offered to every pregnant woman.
Adult ; Anxiety/*prevention & control ; Female ; Fertilization in Vitro ; Humans ; Labor Pain/*therapy ; Pregnancy ; Pregnant Women/*psychology ; Program Development ; *Self Concept ; Stress, Psychological ; *Yoga

PURPOSE: This study was done to identify the relationship between gender-role stereotypes, sexual assault awareness and permissible limits in the college students. METHODS: With a structured survey, a sample of 756 college students who agreed to participate in the study completed a self-administered questionnaire. RESULTS: The result showed that gender-role stereotypes differed significantly depending on gender and age, while awareness of sexual assault differed significantly depending on gender, age, and location of residence. The permissible limits in sexual assault differed significantly according to gender, relationship with parents, and location of residence. There were significant relationships among awareness of sexual assault, gender-role stereotypes, and permissible limits of sexual assault. CONCLUSION: The result will provide preliminary data and strategies to develop sexual assault prevention programs.
Humans ; Parents

OBJECTIVES: The purpose of this study were to examine the level of climacteric symptom, coping and depression among middle-aged women and to identify the relationship between climacteric symptom, coping and depression. METHODS: A descriptive correlational study was conducted. The participants were 275 middle-aged women visiting obstetrics and gynecology hospital in one metropolitan city. Data were collected using a self-administered questionnaire. Descriptive statistics, ANOVA and Pearson correlation were used for data analysis. RESULTS: The mean climacteric symptom score was .54, the mean depression score was .74 and the mean coping score was .35. The level of climacteric symptom, depression and coping were slightly lower than those of other studies. There were positive relationships between climacteric symptom and depression and between climacteric symptom and coping. CONCLUSIONS: To promote physical and emotional health of middle-aged women, more attention is necessary to decrease their climacteric symptom and depression. These results can be used for nursing intervention and care programs for creating better quality of life for middle-aged women.
Climacteric ; Depression ; Female ; Gynecology ; Humans ; Obstetrics ; Quality of Life ; Surveys and Questionnaires

PURPOSE: This study was done to evaluate the effect and retention of CPR training in nursing students. METHODS: The participants were 64 nursing students enrolled in K University in Busan. Data were collected from April 3 to October 20, 2006 using a structured questionnaire. Data were analyzed using the SPSS/PC 12.0 statistical program. RESULTS: The first hypothesis, that knowledge (t=-17.865, p=0.000) and skill (t=-11.216, p= 0.000) scored directly following the teaching program would be higher than before the program, was supported. The second hypothesis, that knowledge (t=-8.325, p=0.171) and skill (t=-9.812, p=0.062) scored directly after the teaching program would be higher than two months later, was rejected. The third hypothesis, that knowledge (t=-9.162, p=0.010) and skill (t=-6.019, p=0.023) scored two months after the program would be higher than four months after the program, was supported. The last hypothesis, that knowledge (t=9.169, p=0.210) and skill (t=-5.012, p=0.319) scored four months after the program would be higher than six months after the program, was rejected. CONCLUSION: Overall retention of CPR training among nursing students, without reinforcement, decreases most significantly between two and four months following initial training. Accordingly CPR training should be repeated with the same clients every four months.
Busan ; Cardiopulmonary Resuscitation* ; Education ; Humans ; Nursing* ; Surveys and Questionnaires ; Students, Nursing*

BACKGROUND/AIMS: Urea breath test (UBT), the noninvasive test for diagnosing Helicobacter pylori infection, was developed in 1987 and had advanced in accuracy and convenience by improvement of analytic device, 13C or 14C urea regimen, expiration sampling protocol and test meal. However, conventional UBT using 75 mg or 100 mg of 13C-urea is expensive and time consuming. The objective of this study was to evaluate the diagnostic performance of UBT using capsulated 38 mg low dose 13C-urea (HeliFinder(R)) developed by Medichems Co., Ltd. METHODS: A total of one hundred forty seven volunteers were enrolled and examined at Catholic University, Korea University, and Soon Chun Hyang University hospital. UBT was performed using 38 mg 13C urea capsule and compared with the gold standard methods (rapid urease test and histology). Baseline and 20 min breath samples were collected. We used delta13C 2.0permile as the cut-off value suggested by the manufacturer. RESULTS: Of the 147 subjects, 142 cases were available for analysis. The sensitivity and specificity of UBT using the 38 mg 13C urea capsule at 20 min were 98.7% and 100% respectively. CONCLUSIONS: A 20 min, 38 mg capsule based 13C urea breath test protocol is more efficient, cost effective, and convenient than conventional protocol.
Breath Tests* ; Diagnosis* ; Helicobacter pylori* ; Helicobacter* ; Korea ; Meals ; Sensitivity and Specificity ; Urea ; Urease ; Volunteers